itac: test is diluted for the values above 250 IU that's why there is some error margin, below 250 it's very accurate
Ya your drop is so big in 1 year. I wounder if these tests really accurate. I question mine but will know more next year. My drop in 2 years was 223, 140 then 79. If i take the measurement i'm droping about 20 to 30 percent per year. If i want to be very positive i might lose hbsag by end of next year (very unlikely)
We do not have insurance system like in US, private healthcare insurance sector is very small and do not covers most expensive cases. Yes, national insurance covers 48 weeks of peginf, with all required tests and doctors visits. Yes it's Roche peginf, but for example if you need entencavir its usually generic one.
In my country, Poland, weekly injection 180mg costs around 200 usd, it's original by Roche. I guess there may be some generic ones available. Here national healthcare insurance covers it always but max for 1 year.
I don't think that insurance company will pay for interferon and will take a risk for side affects with such good liver results. So you may start saving money during next observation year and than buy it on your own. If hbsag won't move down of course, otherwise better wait. Remember to take interferon ONLY under doctors surveilance after initial tests.
Im going to avoid nastiness or sarcasm like you generally write on my posts when I share my results.
But I wanted ask
During this period did you monitor you ALT and AST?
If so from what I understand fluctuating hbsag in this with an elevated ALT can be immune response
But also from what I understand if the ALT alone is elevated this may be an immune response
But if both ALT and AST are elevated it may be due excess of anything including vitamins..
It is kind of funny how you are slowly turning full circle in your thinking after all your critisisms you have had of interferon your now considering trying it :)
Whatever choices you choices you make i hope they are the ones that get you the best results
Just my opinion im not a doctor
with such low value i d try interferon.vit d needs to be optimal range for sure, i don t think it can be bad, also remember that vit d is not an antiviral so up and down on hbvdna may not be immediate
No one can tell you what caused that drop or was it just random. We know that d3 has big impact on immunity we just don't know all details/doses yet.
Also no one can guarantee you a seroconversion but HBsAg < 100 IU is considered as low. If you have constant hbsag drop, especially such impressive like 1 log per yer, better dont touch it :) and let your immune system do its job.
Regarding to hbv dna change, I had a drop from over 5000 IU to 500 IU when starting d3 supplementation but I have no idea was it just coincidence or not, because I haven't tested it before.
I read that level 60-100ng of vit d is perfect so seems that 2000 IU was a good dose for you. Changes of hbv dna from 800 to 1300 means nothing, just a fluctuation.
If test is cheap for you and you dont have to travel you may do this more often to make sure it's not fluctuation but consistent drop. Are you consider interferon when drop will stop ?
Yes, it's almost 1 log reduction, full 1 log would be drop to 221 IU but test sensitivity is +-10% so it doesn't matter.
It's very good decline because most of the people during one year of interferon does not achieve such good drop. Just remember that direction is important and you may know more about it after at least 3 measurements, to make sure it's not just the fluctuation.