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Hepatitis B e Antigen clearance are not always safe
Taiwan paper.
Link : http://jid.oxfordjournals.org/content/205/1/54.full
Link : http://jid.oxfordjournals.org/content/205/1/54.full
Yes, it is working now.
It is not completely safe in the long-term. This we know already. Such is life, at least HbeAg negative chronic HepB can also be controlled by existing drugs.
Background. Hepatitis B e antigen (HBeAg) status and serum hepatitis B virus (HBV) DNA levels are major factors affecting the prognosis of adult HBV carriers; however, the impact of viral load on long-term outcomes after spontaneous HBeAg seroconversion remains unclear.
Methods. A total of 390 spontaneous HBeAg seroconverters with a long-term follow-up were enrolled. Serum HBV-DNA levels at 1 year after HBeAg seroconversion were determined, and their correlation with long-term adverse outcomes was explored.
Results. In a mean follow-up of 6.8 years, the average annual incidence rates were 4.4% and 1.9% for HBeAg-negative hepatitis and hepatitis flare, respectively. Compared with patients with HBV-DNA levels <200 IU/mL, the adjusted hazard ratios of HBeAg-negative hepatitis were 2.4 (95% confidence interval, 1.3–4.4), 3.6 (1.8–7.2), and 5.3 (2.8–10.0), respectively, for serum HBV-DNA level of 2000 −2 × 104, 2 × 104 −2 × 105, and ≥2 × 105 IU/mL. In addition, serum HBV-DNA levels were independently associated with HBeAg-negative hepatitis flare, which confirmed their impact on the immune active hepatitis after HBeAg seroconversion.
Conclusions. HBeAg seroconversion may not always confer favorable outcomes. Serum HBV-DNA levels ≥2000 IU/mL at 1 year post HBeAg seroconversion correlate with increased risk of HBeAg-negative hepatitis and hepatitis flare.
It is not completely safe in the long-term. This we know already. Such is life, at least HbeAg negative chronic HepB can also be controlled by existing drugs.
Background. Hepatitis B e antigen (HBeAg) status and serum hepatitis B virus (HBV) DNA levels are major factors affecting the prognosis of adult HBV carriers; however, the impact of viral load on long-term outcomes after spontaneous HBeAg seroconversion remains unclear.
Methods. A total of 390 spontaneous HBeAg seroconverters with a long-term follow-up were enrolled. Serum HBV-DNA levels at 1 year after HBeAg seroconversion were determined, and their correlation with long-term adverse outcomes was explored.
Results. In a mean follow-up of 6.8 years, the average annual incidence rates were 4.4% and 1.9% for HBeAg-negative hepatitis and hepatitis flare, respectively. Compared with patients with HBV-DNA levels <200 IU/mL, the adjusted hazard ratios of HBeAg-negative hepatitis were 2.4 (95% confidence interval, 1.3–4.4), 3.6 (1.8–7.2), and 5.3 (2.8–10.0), respectively, for serum HBV-DNA level of 2000 −2 × 104, 2 × 104 −2 × 105, and ≥2 × 105 IU/mL. In addition, serum HBV-DNA levels were independently associated with HBeAg-negative hepatitis flare, which confirmed their impact on the immune active hepatitis after HBeAg seroconversion.
Conclusions. HBeAg seroconversion may not always confer favorable outcomes. Serum HBV-DNA levels ≥2000 IU/mL at 1 year post HBeAg seroconversion correlate with increased risk of HBeAg-negative hepatitis and hepatitis flare.
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