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Here are my results. can someone interprete for me?

HBsAg 2815 .... Reactive
HBSAb.21.89 ... Reactive
HBegAG 0.177.. Non reactive
HBeAb 0.003.... Reactive
HBcAb 0.021.... Reactive
HBcIgm 0.048...Non reactive

Liver information:
Biliburin Total ... 22.9
Billiburin Direct...4.21
Protein Total.......73
Albumin.............48
Globulin............25
A/G Ratio...........1.9
AST/SGOT............28
ALT/SGPT...........29
GAMMA GT...........25
ALKALINE DEA.......147

Viral Load

HBV DNA...... Target detected
PCR HBV Quantitative: 7.31× 10^4(Log 4.86) IU/ML
HB2CAP48..... 425576 copies/ml
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Avatar universal
Thank you very much for your insight. The Doctor  suggest a treatment based on Lamivudine while to suppress the load to undetectable level. However i'am afraid of the side effect of the Lamivudine.Thank you anyway. We would follow up the treatment and do in 3 months later the test.
Thank you
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run away from the doctor that is prescribing you lamivudine. that is not a first line of defense treatment, entecavir, viread, (tenofovir) or vemlidy (taf)
20812102 tn?1518988471
You are HBeAg -ve and HBeAb +ve which means you had seroconverted to "non-replicative" chronic hep b phase and ideally your DNA after seroconversion should go down with improvement in liver function blood tests.

Your ALT/AST are within the normal range at 29/28 IU which is a good thing as it means that you have minimal or  no active liver damage happening to your liver.

What concerns me is the high HBV DNA viral load of around 73000 IU/ml. This is high but not crazy high. In a HBeAB+ state, your DNA should go down to less than < 2000 IU/ml and then you will be a true inactive carrier of hepatitis b.

So, here are the two possible interpretations of your result:

Scenario 1: You recently seroconverted to HBeAg -ver & HBeAB +ve state. After this point, HBV DNA will decline to pretty low levels with a decrease in hepatitis activity and an improvement in liver parameters and blood tests. If this is the case, you should get the HBV DNA Viral load test re-done in few months to double check that it is infact declining. Also check with your doctor if he wants to try putting you on entecavir or Tenofovir so reduce the high viral load.

Scenario 2: You seroconverted a while back and your HBV DNA levels probably decline to pretty low levels however, your virus has reactivated (without the seroreversion) to HBeAg -ve  & HBeAb +ve chronic hepatitis b state. This happens in around 15-20% of Inactive Carriers. However you will have to get multiple HBV DNA viral load tests to confirm this.  In this case, the doctor should definitely put you on antivirals to keep the viral load under control and hopefully at undetectable levels.

It's really hard to define the exact phase you are in based on a single point testing of all those tests. You should post either your past blood tests (HBeAg, HBeAb, HBV DNA and ALT) for us to comment "accurately". If you don't have past tests, repeat the same blood tests in 4-5 months and the comparison should help accurately define your phase of hepatitis b.

Note: I am not a doctor so please see a hepatologist to confirm your diagnosis and also ask him if he should put you on antivirals to take the viral load down to undetectable. Ask for a liver ultrasound as well to set a baseline to make sure there is no ongoing damage and/or liver inflamation.

Hope this helps. Goodluck.



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