High Level of AST & ALT

[Raj185]

Hi,

I'm 29 years Male with chronic Hep B. My HBV DNA levels 2 years back was around 157,000 IU/ML and ALT, AST where under normal limits. Doctor suggested to start the medication with 0.5 mg of entacavir as the DNA levels werr high . Since then my DNA level has reduced to  less than 100 IU/ML for the past 2 years. Also my ALT/AST levels were normal for the same period, but when i got these checked again last month they were high AST -44 U/L ALT -111 U/L. My doctor said that Hep B is not the cause for these high levels of ALT/AST. so he suggested few more tests Lipid profile, ANA-IF,Ferritin and ceruloplasmin. In Lipid profile only HDL cholesterol was low 23 (less< 40) and CHOL/HDL Ratio was high 4.8, ANA was negative, Ferritin was 178.2 ng/mL (range 22 - 322 ng/mL) was normal, ceruloplasmin was normal 0.23 g/L (Rangel 0.2-0.6 g/L).

I don't understand what is the cause for my ALT, AST to be high. Please help.

Thanks
Raj

[stef2011]

Yes it is normal for the first few days, on hcv the higher the fever the better the responce to peg, maybe for hbv too

i had 3 days of fever 39.5 i had to use a lot of paracetamol, then it lessened to only 37-37.5 few times after injection.

the fever  goes away after the first few weeks for almost all patients

[Raj185]

hi Stef

I have started my pegintf 2alpha +entacavir treatment from today.

I'm experiencing high fever.  is it normal to experience this

Thanks

[stef2011]

yes it is normal that it goes up and down, it is best to test every 24 weeks like for pegintf to have a clear picture

it is not vit d because it requires months to get stable.results, good or bad, from vit d can be seen after levels are stable with intact pth 10-20pg/ml (when normal range of the lab is 10-80pg/ml) for at least 6 months.i dont indicate vitd25oh because it is different person to person to make pth that low

if pth does not reach that low there is vit d deficiency whatever the vitd25oh results are

[Raj185]

Hi Stef,

I recently got the Hbsag Quantitative test done.

HBsAg Quantitative(CMIA)
26/12/14 - 34268 IU/ml
20/02/15 - 16066 IU/ml
03/03/15 -  27602 IU/ml

I see lot of variation in the results, is it normal. I get the tests done from the same lab and only thing that changed between 2nd and 3rd report is that I started taking Vit D tablets.

Let me you what you feel about this. HBV DNA was undetected recently.

[stef2011]

vit k 2 mk7 at least 90mcg

[stef2011]

vit d must be taken daily, weekly not studied and monthly only worsening health