How to know if Entecavir stopped working

[Aydin1358]

Dear all,
First I have to really thank for all of you who are giving us lots of good information.
I am 33 years old man and I think I have Hep B from birth, because of our family history.
I started taking Entecavir 2 years ago and the reason to start treatment was having 640 milion copy/ml of DNA and ALT more than normal range (almost two times of normal ). So Doctor decided to treat. Almost after a year of taking Entecavir my DNA dropped to 20 copy/ml, but still ALT more than the normal range. Then 6 months later DNA increased to 70 with abnormal ALT and  6 month after that DNA went up to 137 with ALT 70. When I started treatment my Hbeag was positive but after a year it turned to be negative and Hbab get positive.
Now I am a little worried about Entecavir suspecting that maybe virus gets resistance to it because of my DNA increase but doctor telling me that these variations in DNA are ok since it is not too much variations and the most important is that your e-antigen is negative. Yesterday I again tested for DNA test but really I am worried.
Any comments and suggestions will be much appreciated.
Aydin

[Aydin1358]

By the way, My Genotype is D. I was reading in an article ( I will try to find and attach later here) that those with this Genotype showed much chance of clearing hbsag than the other genotypes after 2 years of taking Entecavir. But on the other hand those with D genotype are not good candidate for peginterferon.  Now that I dont respond to entecavir, do you think that still Genotype matters after you get undetactable and want to use peginterferon like you.

[calmama]

If you do decide to take etv+tdf combo, try taking ETV first thing in the morning and eat your breakfast an hour or two later.  Take TDF with dinner.

This is what an old member stevenNYer did when I read the older posts.

[Aydin1358]

Wow. in 5 days. It shows that how  tdf is powerfull. I wish I had chosen tdf from the start, but that day I was thinking what if tdf does not work and then i will have no option.
Anyway I will keep posted here about my latest results and will try to go on combo as soon as possible.

[stef2011]

and ast/alt got more elevated and this is good because it means immune system got more active

[stef2011]

Did your DNA went to undetectable after you took ETV+TDF?

of course it did within 5 days

etv never fully worked from the start i had to add alinia to make hbvdna und and when i stopped alinia hbvdna rebounded to detactable

[stef2011]

i thought it was 137iu/ml, at 23iu/ml you can consider it partial response without resistance

but i dont change my mind because hbvdna in the blood must get to below 0iu/ml since even 0iu/ml in the blood corresponds to plently hbvdna inside the liver, so i am still pro tdf add on

How do you manage to have both ETV and TDF. One needs to be on empty stomach and the other with food. So I think you need to take them separately at different times?

there are many members on his combo here and it is best to take etv and tdf 12hrs apart from eachother
as regards taking etv on empty stomach i stopped this because it is not possible to check every day for empty stomach, after i saw how etv was
useless on me i added tdf and didn t care for empty stomach anymore

my hope is to get rid of these pills as soon as possible by making hbsag low, i dont like taking these chemicals for more than 5 years