Aa
I have fibrosis
Dear All,
I have just joined the forum today and I have read many threads already over the last few months. I want to now start taking more care AND control.
My history is that I have had hep b since 1991. I had biopsy then and my liver was fine. The consultant put me on alpha interferon for 6 months but it did no good or so I was told. Over the next few years I was put on lamivudine and then combo with adefovir. In 2007 I was taken off combo and my hbvdna fluctuated between und and 2000/3000. Recently I had a fibroscan which was inconclusive (But showed around 11.7 kpa). I then had a second biopsy whic showed that I have fibrosis between stage 3 and 4. I was immediately put on tdf and have been on it now for a year.Having said all that I feel great and do lots of exercise in the gym 3/ 4 times a week. I can run 10k on treadmill in 55 minutes.
I take a 1500mg krill oil tablet each day; 3x 60mg blueberry extract ;1000mg garlic and 1 selenium ACE.
I have seen what tests needs to be done in other threads here and I intend to get them done soon . I know that I am anti HBE positive but i do not know the (critically important) IU/ML for the surface antigen yet.
Thank you all for the support given to others here and I am now joining those ranks. I just hope my condition is not too bad??
I have just joined the forum today and I have read many threads already over the last few months. I want to now start taking more care AND control.
My history is that I have had hep b since 1991. I had biopsy then and my liver was fine. The consultant put me on alpha interferon for 6 months but it did no good or so I was told. Over the next few years I was put on lamivudine and then combo with adefovir. In 2007 I was taken off combo and my hbvdna fluctuated between und and 2000/3000. Recently I had a fibroscan which was inconclusive (But showed around 11.7 kpa). I then had a second biopsy whic showed that I have fibrosis between stage 3 and 4. I was immediately put on tdf and have been on it now for a year.Having said all that I feel great and do lots of exercise in the gym 3/ 4 times a week. I can run 10k on treadmill in 55 minutes.
I take a 1500mg krill oil tablet each day; 3x 60mg blueberry extract ;1000mg garlic and 1 selenium ACE.
I have seen what tests needs to be done in other threads here and I intend to get them done soon . I know that I am anti HBE positive but i do not know the (critically important) IU/ML for the surface antigen yet.
Thank you all for the support given to others here and I am now joining those ranks. I just hope my condition is not too bad??
" It is common knowledge that it is not the virus but the immune system that make the damage to the liver, but how then a spontaneous virus clearance is explained" - yes is common understanding that immune system make the damage, but I wish to know to explain spontaneous clerance :)
"It happens without uprising of ALT and liver inflammation? Is it not the immune system who cleans the virus? " - I don't know. I think that immune sistem clear the virus and I assume that some liver inflammation can occurred, but this will be regenerated after that
"f the immune system causes the damage, then why do we need to take all those vitamins and minerals to stimulate the immune system?" - Not necessary to stimulate, maybe to help will be a better word (help can also mean to lower down the inflammation)
"interferon treatment actually simulates it too and the damage is suspended while you are on INF." - I don't think that damage is suspended, contrary I think that damage is some how bigger, but it will be suspended after that and the liver can regenerate beater
"If we to follow this logic than it would be a good strategy for inactive carriers to keep the immune system down and wait till new drug gets to the market..." - can be, I have no idea what is the best, but I think that with normal ALT/AST, Fibroscan F0/1, HVB DNA < 2000 UI we are on the safe part - this has to be monitored. Also I think that qHBSAg has to be monitored and if we found qHBSAg less then 1500 UI we can try to go on interferon and try to lose HBSAg and also for the people that have more then 45 year old I think that is indicated to go on the NUC and stay on the NUC if HVB DNA is not undetectable. But all this is only what I think, I'm not a doctor and my understanding on this subject is limited.
"It happens without uprising of ALT and liver inflammation? Is it not the immune system who cleans the virus? " - I don't know. I think that immune sistem clear the virus and I assume that some liver inflammation can occurred, but this will be regenerated after that
"f the immune system causes the damage, then why do we need to take all those vitamins and minerals to stimulate the immune system?" - Not necessary to stimulate, maybe to help will be a better word (help can also mean to lower down the inflammation)
"interferon treatment actually simulates it too and the damage is suspended while you are on INF." - I don't think that damage is suspended, contrary I think that damage is some how bigger, but it will be suspended after that and the liver can regenerate beater
"If we to follow this logic than it would be a good strategy for inactive carriers to keep the immune system down and wait till new drug gets to the market..." - can be, I have no idea what is the best, but I think that with normal ALT/AST, Fibroscan F0/1, HVB DNA < 2000 UI we are on the safe part - this has to be monitored. Also I think that qHBSAg has to be monitored and if we found qHBSAg less then 1500 UI we can try to go on interferon and try to lose HBSAg and also for the people that have more then 45 year old I think that is indicated to go on the NUC and stay on the NUC if HVB DNA is not undetectable. But all this is only what I think, I'm not a doctor and my understanding on this subject is limited.
Nothing special, just reduce the meat quantity from diet.
Also I take some vit D supliments, but I don't know if any relation between this and reduce iron level.
as far as i know you can go and "donate" blod in order to decrease your iron level ("donate" = give away because you have to declare that you have hbv in order that your blood not to be pass to other people)
Also I take some vit D supliments, but I don't know if any relation between this and reduce iron level.
as far as i know you can go and "donate" blod in order to decrease your iron level ("donate" = give away because you have to declare that you have hbv in order that your blood not to be pass to other people)
Please comment on the this contradiction. It is common knowledge that it is not the virus but the immune system that make the damage to the liver, but how then a spontaneous virus clearance is explained, It happens without uprising of ALT and liver inflammation? Is it not the immune system who cleans the virus?
And another question. If the immune system causes the damage, then why do we need to take all those vitamins and minerals to stimulate the immune system? interferon treatment actually simulates it too and the damage is suspended while you are on INF.
If we to follow this logic than it would be a good strategy for inactive carriers to keep the immune system down and wait till new drug gets to the market...
And another question. If the immune system causes the damage, then why do we need to take all those vitamins and minerals to stimulate the immune system? interferon treatment actually simulates it too and the damage is suspended while you are on INF.
If we to follow this logic than it would be a good strategy for inactive carriers to keep the immune system down and wait till new drug gets to the market...
Hi -
I have iron level of about 160...and want to get it down to less than 100.
I notice that you have reduced your iron level from 176 downward to 115 (during the year from July 2011 to July 2012) - Congratulations!!...and how did you accomplish this??
Please advise - thanks!
I have iron level of about 160...and want to get it down to less than 100.
I notice that you have reduced your iron level from 176 downward to 115 (during the year from July 2011 to July 2012) - Congratulations!!...and how did you accomplish this??
Please advise - thanks!
Thank you for your comments. I have to read this and also some other stuff in order to understanding correctly and to see the corelations.
I had look on my test results and indeed, once in Nov 2011, beside Iron Serum test I made the Feritin test and was 184 and also Transferrin saturation that was 0.49 (normal range 0.25 - 0.35).
I had look on my test results and indeed, once in Nov 2011, beside Iron Serum test I made the Feritin test and was 184 and also Transferrin saturation that was 0.49 (normal range 0.25 - 0.35).
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