IFN course

[calebz]

Hi

Was sharing my status and though I should maybe share my current experience with IFN.
I'm currently 29. First diagnosed 2012 January. First HBV DNA June2012 was about 214000 IU.
I was HBeAg Negative then. For some reason at baseline I became HBeAg Positive.

My baseline
DNA ~170000 IU
qHBsAg 4500 IU
ASP/ALT 40/60
Fibroscan 6,6 Kpa

Week 4
DNA 67000 IU
qHBsAg 4700 IU
ASP/ALT 35/55

Week 8
DNA 6000 IU
qHBsAg 3900 IU
ASP/ALT 35/55

Week 12
DNA 3000 IU
qHBsAg 4700 IU
ASP/ALT 36/54


My ALT/ASP is generally unchanged, DNA keeps dropping but HBSaG is really scaring me. Doc says we need to wait for a pattern to take out any conclusions and consider stopping treatment.
One thing I can think of is before that Week 12 visit I went to a gym a few times and skiing where I got tired like crazy.

[stef2011]

get tenofovir and retry peg in 3-5years time when hbsag will be low at around 1500iu/ml

for the baby you can have etv or tdf it makes no difference and no effect on baby

[calebz]

Hey

Just had my week 72 visit, my DNA completely rebound to 110000iu/ml and hbsag increased from 3300 to 4000 so I'm back where I was at start. At least my Fibroscan stays at 6.8Kpa.

I think I will go on NUC's. My public health care changed treatment guides and I think it opened up Baraclude (and I think tenofovir too) for Hbe-.
Haven't seen the program details cause its fresh news.

Too bad its almost a permanent medicine and I'm still trying for a child.
Anybody had any experience in Tenofovir in men trying to conceive ? Label says it had no issues with rats...

[stef2011]

You can try staggered pegintf like stop 1 to 3 months, make hbvdna und and then restart pegintf or just add on nucs to pegintf mono before going to few years nucs mono

[grmr]

hi cale.. same situattion here..  NUC's will not be a choice due to the young age (same of mine!)... in any case I beliver you'll do agaign modno ifn in some months (at least 10/12 months since the end of the tx)..

[calebz]

Hey

Just had my week 64 visit.
At week 60 my dna raised to 7000 IU and my HBsAg stopped at 3300IU levels. ALT/ASP 45,40.

Fibroscan results F0-F1 6.8Kpa.

I envy you folks with IFN response :( Time too look at NUC's for me.

[mustthinkpositive]

Your HBsAg looks good on a downward trend. Hope it continues.