GCMAF therapy

[stef2011]

first low dose 0.125ml, everything ok, i feel nothing unusual

headache or tireness are sometimes reported as the immune system activates at first injections but i felt nothing

[almaja]

So you can get this treatment done by your request even if is not actuali hbv treatment.?

[StephenCastlecrag]

Good luck.

[stef2011]

gcmaf is a treatment for immune system disfunction which is present in all cronic diseases (if immune system was working there would be no disease...) so it is a therapy for cronic hbv

as we have posted many times immune system on cronic hbv is absent, there is no immune response towards hbv

the immune suppression is due to the enzyme nagalase on the surface antigen of hiv and probably hbv too.my nagalase was very abnormal, higher than that of hiv and cancers

[almaja]

I wish you all the luck with thet treatment.When are you going to folow up on thet ?

[cam4930]

Where did you get it? Oral or injection?

[stef2011]

two labs do it in europe and one in israel:

www.bgli.nl and http://www.gcmaf.co.uk/info/ (about same price around 2000euro/24 shots)
http://pps.co.il/ (supposed to be the most potent but too expensive 24 shots 24000euro)

injection (both subc or IM are ok butIV is the most potent)

nagalase can be tested in netherlands only, shiping blood samples to the lab is complicated because it must be frozen and arriva before friday

[stef2011]

end of the day effect, extremely sleepy after dinner.....gone to bed earlier than usual

[hepbvictim]

Best of Luck Stef.

woudl you mind copying the link for the backgfround of GCMAF Therapy?

[stef2011]

woudl you mind copying the link for the backgfround of GCMAF Therapy?

what do you mean?the link for all the research?

research is on pubmed but all research is linked on these websites

gcmaf.eu

bgli.nl

[stef2011]

for all the members, keep in mind that nagalase is linked to both viruses and cancers and that nagalase is abnormal before cancers are detactable so it is a very good tool as a tumor marker

[stef2011]

i have found this study on macrophages and hbv/hcv infections.it explains how these viruses hijack/alter immune responses from the begining, exactly starting from macrophages which are the first step of immune activation or tollerance

another analogy is that the new gilead drug activates tlr 7 receptor on macrophages while gcmaf activates all macrophages receptors.....activation of tlr7 has an effect on both hbv and hcv, on hbv leads to hbsag and hbvdna decrease.

i will ask gcmaf recerchers if it will activate also tlr7 receptor, in this case gcmaf will work even better that the new gilead drug (so sorry for them if this happens to be true...their drug will be a failure even before trials)

http://jvi.asm.org/cgi/reprint/83/7/2796.pdf

conclusions of the study:
In summary, HBV and HCV, via an assortment of mechanisms, disturb immune responses and establish chronic infections, with macrophages as key regulators of the early
immune responses being targeted by both viruses.

CONCLUDING REMARKS:
Do liver macrophages function efficiently
during HCV and/or HBV disease, and can they be a target for
immune therapy to control HBV and/or HCV disease

[stef2011]

another study:
Hepatitis B virus hardly activates dendritic cells,
macrophages and natural killer cells

http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022

[vijik]

has gilead also discovered drug to eradicate hbv by activating immune system? interesting to see the developments. if such one come from drug makers i think they would definitely be trying to price as much as high in order to compensate themselves from the loses of life-time drugs like etv and tnf.

but the gcmaf looks like superior of all other drugs in activating immune system.

[stef2011]

http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022

In addition to DCs, macrophages (Møs) also play a role in the innate immune system. It is shown that
the MR plays a role in HBsAg uptake by mDC [7]. Macrophages express MR [56] and therefore these
cells might be an important target for HBV.

Taken together, the general observation was that HBV did not change the cytokine profile in both Mø1
and Mø2. However, HBV might be able to reduce the cytokine production in both the macrophages
subtypes, but the observed reduction was limited to Pam3CysK4-treated Mø1 or IFNK-treated Mø2

22
5. Conclusions/discussion
Weak antiviral B and T cell responses are believed to be responsible for the lack of virus control in
chronic HBV patients [5]. The mechanism behind this immunological failure is still not understood. In
sharp contrast to other viruses, chimpanzees as well as human individuals infected with HBV showed
a complete lack in the induction of type I IFN and in IFN-response genes during the early stages of
infection [60, 61] , indicating a lack of activation of the innate immune system. The lack of effective HBVspecific
immunity could be due to inadequate activation of innate immune cells, but may also be due
to active immune modulation. It is recently observed that several viruses escape immunity via
targeting DC and Møs functions. For example, Vaccinia, Hepatitis C virus (HCV), Human
Immunodeficiency Virus (HIV) and measles virus infections are associated with impaired macrophage
and DC function [5, 62-67]
Here we report that HBV is not a strong inducer of innate immune responses. DC and Møs were not or
only weakly activated by HBV, resulting in marginal immune stimulating effects with respect to
cytokine production and NK cell activation. Immune suppressive effects of HBV were hardly observed.
Only in a few experiments/donors HBV reduced the production of pro-inflammatory cytokines by Mø1,
whereas Mø2 showed a reduction in both anti- and pro-inflammatory cytokines.

[stef2011]

it is clear that immune suppression is probably due to nagalase blocking macrophages activation,
it would be useful that others check nagalase to see if it is so high as mine so that we can definitely prove that immune suppression is due to nagalase in cronic hbv carriers

as to hbv clearance we will have to wait and see if hbv has other ways to escape immune system after macrphages maximum activation

[stef2011]

my next point will be to have vdr receptors genetic test to see if i am a fast responder or slow responder to gcmaf...but i have to find this test for free in a way or another because it is as expensive as 18 shots of gcmaf....

[stef2011]

http://www.redlabs.be/documents/Request%20Form%2008-10IMMUen.pdf

i made confusion VDR is not expensive, 68€ at red labs but i will try it to have it free in italy if available

[stef2011]

very good presentation of gcmaf and nagalase human trials and studies

http://www.marcoruggiero.org/pdf/GcMAF%20at%20the%20NIH.pdf

[stef2011]

first full dose of gcmaf, no effects

the following day i am feeling real great, very powerful and relaxed.the extreme irritation or slow mind i used to have since i started entecavir is complitely gone

[stef2011]

no effects....

of course i mean no bad effects, blood tests are for the 26th of may (5th shot of gcmaf)

[StephenCastlecrag]

Keeping all our fingers crossed for you :-)

[kinetix1208]

I read and watch about the GcMAF therapy and the results are really promising. It's like a natural way of treatment by awakening your immune system and with considerably no side effects. Although it's too expensive for us but it will be worth it on saving money for that.

You started your first shot on May 4 right? So its a daily thing you should do. When do you stop taking that shot? Can I ask your hepa b profile record before taking it? I just wanted to know what are the areas that will probably boost your immunity.

Please keep us posted with your results.

[stef2011]

You started your first shot on May 4 right? yes, it is one injection every 5 days or 6 days because macrophages live for 6 days only so you have to reactivate the new borns with new gcmaf after 6 days

Can I ask your hepa b profile record before taking it?
hbvdna und, alt 31, hbsag about 6000iu/ml

know what are the areas that will probably boost your immunity.
gcmaf will increase monocites, activate all macrophages receptors even the one for hbsag, this should start an immune reaction increasing all antibodies and making hbsag negative

i combo with entecavir and nitazoxanide, this might lower the immune response but i cannot stop them because i cannot risk a lot of liver damage

[kinetix1208]

Thanks for the information Stef. I'm positive that this will work for all of us, hope this will be it. :)

One thing, are there any reported situation that actually overdosed with this kind of therapy? and what happened?