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If Alinia reduces HBsAG level then...

Theoretically, in some patients wouldn't this dramatically increase that patient's chance of clearing HBsAG if used with NUC's?  If so, then Alinia, perhaps after years of use, might give some people a chance to get rid of the HBV virus and attain immunity.  Or do I have this wrong?
6 Responses
Avatar universal

you are right and in our group we saw that the most potent combo is alinia+peginterferon since both are immune modulators, with nucs the results are slower and on hbe negative, very little on hbe pos

from boston we have a research on the most potent nuc on hbsag and it is entecavir not tenofovir, i woundered for a long time why romark wanted to start the trial of alinia+entecavir and not tenofovir in 2009 and this is the answer, too bad they never started the trial but i understand they need money for these trials

i think that also simvastatin might help and vitamin d supplements since they are immune modulators and probably active not only on peginterferon but on alinia too
Avatar universal
simvastatin will help but not as immune modulator but reducing cholesterol for hbsag production, it is also good to note that both sim and alinia are active on all hbv strains so they might prevent resistance in case of nucs combo

another thing to keep very clear is that 1g alinia daily looks mostly ineffective since the maximum blood half-life of active level of alinia taken with food is 7 hours only so it is necessary to take alinia every 7-8 hours according to the total daily dose if 1.5 or 2g

2g can lower healthy bacteria in the stomach of some so probiotics are suggested

on the 2g dose of alinia and on simvastatin it is better to check main blood tests, liver tests and creatinine for kidneys every 6 months
Avatar universal

i do suggest to read the study of korba and bader i posted on simvastatin, there are 3 main interesting points:
potent anti hbv activity, still in vitro but if used as a combo we have nothing to lose if in vivo it doesn t work
cirrhosis, reduction of portal ipertension
liver cancer, reduction of HCC
Avatar universal

i do suggest to read the study of korba and bader i posted on simvastatin, there are 3 main interesting points:
potent anti hbv activity, still in vitro but if used as a combo we have nothing to lose if in vivo it doesn t work
cirrhosis, reduction of portal ipertension
liver cancer, reduction of HCC
Avatar universal

i do suggest to read the study of korba and bader i posted on simvastatin, there are 3 main interesting points:
potent anti hbv activity, still in vitro but if used as a combo we have nothing to lose if in vivo it doesn t work
cirrhosis, reduction of portal ipertension
liver cancer, reduction of HCC
Avatar universal

i do suggest to read the study of korba and bader i posted on simvastatin, there are 3 main interesting points:
potent anti hbv activity, still in vitro but if used as a combo we have nothing to lose if in vivo it doesn t work
cirrhosis, reduction of portal ipertension
liver cancer, reduction of HCC
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