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Avatar universal

I'm so confused with my HBV DNA results

Can you guys tell me what #s am I suppose to look at?
Here is what the results report look like.

                                                   Value                Flag                Reference Range
HEPATITIS B DNA QNT PCT         4.0                    H                    < 1.6 log IU

**** Viral load result for HBV DNA is 9,450 IU/ML***        

1 IU/ML is 5 copies/mL.

My question is what does the 4.0 stand for? Is it the same as 9,450 IU/ML? so i have 47,250 copies/mL?

I quote, "The National Institutes of Health have suggested that viral loads that exceed 100,000 copies/mL are “clinically significant.” and "If the HBV DNA level remains below 200 IU/mL, that indicates an "inactive" carrier state of the infection."

So am I borderline for treatment?

It will probably be another month before I get to see a hepatologist. Is there anything I can do now to decrease my DNA level? exercise ? Can stress increase DNA level? Thanks.
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Avatar universal
Zelly,

I found out my ALT is 27 but the normal range is 6-23. I don't know whta that means? My doc said it's normal though.
Helpful - 0
Avatar universal
The only real way to know what is going on in the liver is to biopsy and even that is somewhat suspect.  A lot depends up on the sample size/quantity/location.  There are other markers that may give some indication but are not reliable on their own (bilirubin, AST/ALT ration, platelets etc).  I think you can get the most complete picture with the labs,imaging and biopsy but of course, that is costly and not everyone will get that.

I ask about the ALT b/c "normal" doesn't always mean "healthy".  Some labs set normal at <60 but a healthy liver function for men is 30 at the upper limit and for women is 19 (upper limit).  The lab values are somewhat skewed by the population sample.  

My own doctor told me my labs were normal for 8 years...welll, they weren't.  They were high for a woman...still are.  But they were normal by lab values (and even by what was understood at that time).  
Helpful - 0
Avatar universal
My primary doctor will send me the hard copies results. I will know my AST and ALT #s when I get them. According to him, all liver panel enzymes are normal.

He referred me to a hepatolgist but I have not receive any call from hepatology regarding my referral. I expect an appointment with them within the next month or so. I don't have a recommendation to treat or not by a hepatologist because I have not seen one yet.

Is it true that even though you have high viral load, it doesn't necessary mean you have liver damage unless high levels of ALT?

Zelly, I asked you the question before of the half-life of HBV. Well I researched it and it's ~1 day. The paper indicate that a full equiped virus will circulate in your blood and be gone within a day. I don't know what happen to it, either they get kill or they get incorporated into hepatocyte.
Helpful - 0
Avatar universal
Did your doctor recommend no treatment yet?  I would think that is logical.  I am sure he will also keep you monitored.

As zellyf said, you look pretty good.
Helpful - 0
Avatar universal
What are the AST, ALT numbers?

Get hard copies of your labs and keep them.

I would get another round of labs in three months, and three months after that...if stuff holds or drops then I'd go bto twice a year with a yearly ultrasound.  Get an ultrasound no matter what...yearly. This all looks good.
Helpful - 0
Avatar universal
I did a comprehensive blood panel (CBC) and a liver panel yesterday. The results came back today.

My doctor said everything was normal except my BUN was a little high. BUN is use to measure kidney function.

What do you guys think, treat or not treat with the summary below:

1) Eg negative, Eab positive.
2) Viral count as of last week is ~45,000 ml/copies.
3) liver panel (AST,ALT) normal
4) I'm 27 y.o.

If I fall into the e- negative group, I read that treatment is only recommended if the high viral load is couple with high ALT,AST.

Should I wait and get retested for viral load at 3 months and 6 months and re-evaluate treatment?

In the back of my mind, I keep thinking that I may have just ended serconversion,hence, the e neg status but still elevation in viral load. If I wait at 3 months, maybe my viral load will go down to UND and I'll be inactive?

What is the next step, ultrasound? Biopsy?
Helpful - 0

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