Importance of vitamin d levels to help control HBV replication

[studyforhope]

Hepatology. 2013 May 22. doi: 10.1002/hep.26488. [Epub ahead of print]
Low vitamin D serum concentration is associated with high levels of hepatitis B virus (HBV) replication in chronically infected patients.
Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.
Source
Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Haus 11, 60590 Frankfurt, Germany.
Abstract
Vitamin D is an important immune modulator which plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B is less well characterized. Therefore, we quantified 25-hydroxyvitamin D [25(OH)D3 ] serum levels in a cohort of 203 treatment-naïve patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of chronic hepatitis B. 69 (34%), 95 (47%), and 39 (19%) out of 203 patients had severe vitamin D deficiency [25(OH)D3 <10ng/mL], vitamin D insufficiency [25(OH)D3 ≥10ng/mL and <20ng/mL], or adequate vitamin D serum levels [25(OH)D3 ≥20ng/mL], respectively. In both uni- and multivariate analyses, HBV DNA viral load (log10 IU/mL) was a strong predictor of low 25(OH)D3 serum levels (p=0.0007 and p=0.000048, respectively), and vice versa. Mean 25(OH)D3 serum concentrations in patients with HBV DNA <2000 IU/mL vs. ≥2000 IU/mL were 17 vs. 11 ng/mL, respectively (p<0.00001). In addition, hepatitis B early antigen (HBeAg) positive patients had lower 25(OH)D3 serum levels than HBeAg negative patients (p=0.0013). Finally, 25(OH)D3 and HBV DNA serum levels showed inverse seasonal fluctuations. Conclusions: Low 25(OH)D3 serum levels are associated with high levels of HBV replication in patients with chronic hepatitis B. This represents a major difference to chronic hepatitis C, were numerous previous studies have shown a lacking correlation between HCV viral load vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D3 and HBV DNA serum levels are suggestive for a functional relationship between both variables. (HEPATOLOGY 2013.).
Copyright © 2013 American Association for the Study of Liver Diseases.

[stef2011]

the thousands of human studies on thousands of people done on vitamin d are on this website:

http://www.vitamindwiki.com/VitaminDWiki

[stef2011]

definitely no effect on creatinine whatsoever, was it a real human study with a lot of patients peer reviwed or the usual drug makers spam over vit d use?
because there are tones of spam article on vit d use and sun exposure......

1hr sun makes 20.000iu of d3, a big dose is 100.000 to 600.000iu and it is given by injection twice a year to make normal vit levels and creatinine stays the same also on these doses

[OrientS]

RESEARCHERS FIND LINK BETWEEN LOW VITAMIN D, HEPATITIS B
1 hour ago

http://www.foodproductdesign.com/news/2013/06/researchers-find-link-between-low-vitamin-d-hepat.aspx


Vitamin D Deficiency May Help Spread Of Hepatitis B Throughout Liver
June 6, 2013

http://www.redorbit.com/news/health/1112866582/vitamin-d-deficiency-may-help-spread-of-hepatitis-b-throughout-liver/

[mustthinkpositive]

Another thing, is it not high vitamin D dose bad for the liver? Thx.

[mustthinkpositive]

To those that take 10,000 iu Vit D3 daily, any sides?

Also, veteranB, is your HBV DNA UND? HBEAG + or -?

[Jeff912000]

Vitamin D causes the serum creatinine to go up probably by competitive excretion.  So if you guys are taking big doses, better to stop the VitaminD for two weeks or one month before measuring serum creatinine.  Otherwise you may get a shock.  It is not causing damage but just an effect of the drug.  That is while sunshine is better.  Sunshine does not cause this side effect.