Aa
Is it ok to use baraclude(enticavir 0.5mg) with cialis (tadalafil 20 mg)?
Is it ok to use baraclude(enticavir 0.5mg) with cialis (tadalafil 20 mg)?
Is there any bad interaction between them?
does tadalafil 20 mg affect on liver adversely?
Is there any bad interaction between them?
does tadalafil 20 mg affect on liver adversely?
http://livertox.nih.gov/Tadalafil.htm
Hepatotoxicity
Despite fairly extensive use, tadalafil has been linked to only rare reports of serum aminotransferase elevations and clinically apparent liver injury. In a single case report, tadalafil was linked to cholestatic hepatitis arising within a few days of starting the medication. Immunoallergic features and autoantibodies were not present. The injury was self-limiting without residual evidence of bile duct injury. The related PDE5 inhibitor, sildenafil, has also been associated with rare cases of acute cholestatic liver injury with jaundice.
Mechanism of Injury
The mechanism of liver injury from tadalafil is unknown, but it is metabolized in the liver via the cytochrome P450 system (CYP 3A4) and a toxic or immunogenic intermediate may account for the rare instances of hepatic injury linked to its use.
Outcome and Management
The liver injury linked to tadalafil has been self-limited and resolving within 2 to 3 months. There is no known cross-sensitivity between tadalafil and the other PDE5 inhibitors currently in use in the United States, but switching to another PDE5 inhibitor should be done with caution.
Hepatotoxicity
Despite fairly extensive use, tadalafil has been linked to only rare reports of serum aminotransferase elevations and clinically apparent liver injury. In a single case report, tadalafil was linked to cholestatic hepatitis arising within a few days of starting the medication. Immunoallergic features and autoantibodies were not present. The injury was self-limiting without residual evidence of bile duct injury. The related PDE5 inhibitor, sildenafil, has also been associated with rare cases of acute cholestatic liver injury with jaundice.
Mechanism of Injury
The mechanism of liver injury from tadalafil is unknown, but it is metabolized in the liver via the cytochrome P450 system (CYP 3A4) and a toxic or immunogenic intermediate may account for the rare instances of hepatic injury linked to its use.
Outcome and Management
The liver injury linked to tadalafil has been self-limited and resolving within 2 to 3 months. There is no known cross-sensitivity between tadalafil and the other PDE5 inhibitors currently in use in the United States, but switching to another PDE5 inhibitor should be done with caution.
Have an Answer?
You are reading content posted in the Hepatitis B Community
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
