Is it possible to switch from Tenofovir to Entecavir?

[luckyman316]

I'm just curious to know if this is something that is possible or if taking Tenofovir will build you a resistance to Entecavir?

[luckyman316]

Stef, as always, your knowledge is much appreciated!

[stef2011]

if you have free entecavir available in your country that s ok too, difference of potency is little

[stef2011]

no, all drugs are free from healthcare system

you can buy generics in india which are extremely cheap starting from as low as 20usd  per month, cipla is a very good brand

[melcul]

Stef whats the price of tdf in italy ? I dont have it here, can i buy it from there without prescription?

[stef2011]

no you dont have to try we know tdf is the most potent

tdf hbeag neg 5 years 98% of hbvdna und, 0% resistance
etv  hbeag neg 5 years 95% of hbvdna und, 1.2% resistance

[melcul]

I understand. So you have to try them to see if you respond. Does anybody know whats the respond rate or what percent does bot respond to this antivirals (entecavir / tenofovir ) ?

[stef2011]

no it means that if you never used other antivirals and built resistance to them you won t build resistance to tdf

tenofovir will not make resistance even if hbvdna suppression is not complete

[melcul]

So having 0% resistance that means anyone will respond to tenofovir ?

[stef2011]

tenofovir has 0% resistance so it cannot build any resistance while the opposite may happen with all the other antivirals

especially entecavir which makes many mutations for resistance....2 cases have been found not to respond to tdf anymore after etv resistance and multiple antiviral resistance