My Clinical Trial (TDF vs. TAF) Post Medication Resutls

[luckyman316]

Wanted to see if anyone can offer any advice. Before I started this, I did not have all these results. My viral load started a 276,000 when I first learned of Hep B, spiked up to 5 million, 12 million and now this (and last result actually was 23 million but I do not have those results in front of me).

Is this an active Chronic infection? Any chance to tell how long I've had this? Or are there any tests to determine how long I've had it?

CBC Results:
WBC - 7.0
RBC - 4,79
Hemoglobin - 14.8
Hematocrit - 45.1
MCV - 94
MCH - 30.9
MCHC - 32.8
RDW - 13.8
Platelets - 254
Neutrophils - 56
Lymphs - 32
Monoctyes - 9
Eos - 3
Basos - 0
Neutrophils (absolute) - 3.9
Lymphs (Absolute) - 2.3
Monocytes (Absolute) - 0.6
Eos (Absolute) - 0.2
Baso (Absolute) - 0.0
Immature Granulocytes - 0
Immature Grans (Abs) - 0

Comp. Metabolic Panel
Glucose - 83
BUN - 20
Creatinine, Serum - 1.16
eGFR If NonAfrican Am - 81
eGFR if African Am - 93
BUN/Creatinine Ratio - 17
Sodium, Serum - 142
Pottasium, Serum - 4.1
Chloride, Serum - 103
Carbon Dioxide, Total - 24
Calcium, Serum - 9.6
Protein, Total Serum - 6.6
Albumin, Serum - 4.3
Globulin, Total - 2.3
A/G Ratio - 1.9
Bilirubin, Total - 0.5
Alkaline Phosphatase, S - 71
AST (SGOT) - 61
ALT (SGPT) - 115

Urinanalysis Gross Exam
Specific Gravity 1.027
pH - 6.0
Urine-Color - Yellow
Appearance - Clear
WBC Esterase - Negative
Protein - Negative
Glucose - Negative
Ketones - Negative
Occult Blood - Negative
Bilirubin - Negative
Urobilinongen, Semi-Qn - 0.2
Nitrite , Urine - Negative

HBV Real-Time PCR, Quant
HBV IU/mL - 18,907,000
log10 HBV IU/mL - 7.277
HBV Copies/mL - 110,040,000
log10 HBV Copies/mL 8.042

Panel 083824
HIV 1/0/2 Abs-Index Value <1.00
HIV 1/0/2 Abs, Qual - Non Reactive

HBV Genotype/PreCore
HBV Genotype - HBV Genotype D detected
HBV PreCore Mutation - Basal Core promoter mutation at 1764 was detected. HBV PreCore Mutation 28 was detected.

Prothrombin Time (PT)
INR - 1.1

AFP, Tumor Marker (serial)
AFP, Serum, Tumor Marker - 1.7

TSH - 1.770

PTT, Activated
aPTT - 26

Hep B Surface Ab
Hep B Surface Ab, Qual - Non-Reactive

Mitochondrial (m2) Antibody - 2.8

Vitamin D, 25-Hydroxy - 59.6

HCV Ab w/Rflx to Verification
HCV Ab - 0.1

Phosphorous, Serum - 4.0

Antinuclear Antibodies Direct
ANA Direct - Negative

Ferritin, Serum - 258

HBsAg Screen - Positive Abnormal

Hep Be Ag - Negative
Hep Be Ab - Positive Abnormal
Thyroid Peroxidase (TPO) Ab - 8
Hep B Core Ab, Tot - Positive Abnormal
Hep A Ab, Total - Negative

So yes, happy my vitamin D levels went up from 14. Still feel I could use 20 more points on there. Also need Hep A vaccine. The rest is good, except for the Hep B portion which I need to clear.

[studyforhope]

dont worry about some crystals in the urine. drink more water and you should be fine.
the mucous has no significance.
the creatinine is more of a problem, you do need the cystatin c to independently test glomerular filtration capacity. Insist on it to be repeated.

[luckyman316]

Just wanted to share latest results:

HBV DNA IU/mL: < 29 IU/mL HBV DNA Detected
Total Bili: 0.3mg/dL
Dir Bili :  < 0.1 mg/dL  
Ind Bili : <0.3 mg/dL  
AST (SGOT) - 35 (down a few points)
ALT (SGPT) - 53 (down from before, thankfully)
Creatine - 1.26 mg/dL   (.02 higher than top end)
Uric Acid - 7.5 mg/dL  
Calcium - 9.8 mg/dL  
Phosphorus - 3.3 mg/dL
pH - 5.5  
CK - 213 U/L  (this number jumped up a LOT)
Parathyroid Hormone - 60.4 pg/mL (Again, up a LOT)

I'm concerned about all these and then this comes up with urine test:


CRYSTALS: Ca OX Present
MICELLANEOUS ELEMENTS: MUCOUS

How does one even get mucous in their urine? I am not sexually active so this is a shock to me

But then I see other lab:

CS&GCtrlClr KX 34.2 which is low
Apparently lots of other required testing was "unavailable"

Then I saw this and it alarmed me that this lab could just be wrong:
CYSTATIN C - MISHANDLED BY LAB


I wonder what all happened here? Very odd!!

Anyway, I've generally been feeling pretty decent and such, and am not concerned any more at this point about overanalyzing it all. We'll see what happens in 2 months.

[stef2011]

that s a trick so in the trial you can have higher percentages of so called undetectable and put in very small writing below (hidden) und is <29, are they smart?

[luckyman316]

Sorry I have not been as active, updating more. They are now watching me every 2 months. I got results from my latest DXEA Scan about a month after it happened. Here it is:

Region: Spine L1, BMD: 0.889, BMC: 11.1, Area: 12.51, TScore: -2.3, ZScore: -2.3

Region: Spine L1-L2, BMD: .973, BMC: 25.5, Area: 26.23, TScore: -1.9, ZScore: -1.9

Region: Spine L1-L3, BMD: 1.021, BMC: 41.0, Area: 40.19, TScore: -1.6, ZScore: -1.6

Region: Spine L1-L4, BMD: 1.035, BMC: 57.6, Area: 55.68, TScore: -1.5, ZScore: -1.5

Region: Spine L2, BMD: 1.049, BMC: 14.4, Area: 13.72, TScore: -1.6, ZScore: -1.6

Region: Spine L2-3, BMD: 1.080, BMC: 29.9, Area: 27.68, TScore: -1.3, ZScore: -1.3

Region: Spine L2-4, BMD: 1.077, BMC: 46.5, Area: 43.17, TScore: -1.4, ZScore: -1.4

Region: Spine L3, BMD: 1.110, BMC: 15.5, Area: 13.95, TScore: -1.1, ZScore: -1.1

Region: Spine L3-L4, BMD: 1.090, BMC: 32.1, Area: 29.45, TScore: -1.3, ZScore: -1.3

Region: Spine L4, BMD: 1.071, BMC: 16.6, Area: 15.49, TScore: -1.4, ZScore: -1.4

Spine Total Adequate BMD: 1.035, BMC: 57.6, Area: 55.68, TScore: -1.5, ZScore: -1.5

Region: L.FemurNeck, BMD: 0.929, BMC: 4.7, Area: 5.02, TScore: -1.1, ZScore: -0.8

Region: L.FemurShaft, BMD: 1.145, BMC: 17.6, Area: 15.38, TScore

Region: L.FemurTotal BMD: 0.959, BMC: 31.7, Area: 33.01, TScore: -1.0, ZScore: -0.8

Region: L.FemurTotalAdequate BMD: 0.959, BMC: 31.7 Area: 33.01

Region: L.FemurTrochanter BMD: 0.744, BMC: 9.4, Area: 12.60 TScore: -1.7, ZScore: -1.6

Region: L.FemurWards BMD: 0.749, BMC: 2.1, Area: 2.80 TScore: -1.6, ZScore: -1.3

If I compare this to the other post in this thread, it's clearly obvious there is slow bone density loss going on here. This further makes me believe that I am on the old drug on this trial. Feel free to comment.

[luckyman316]

Clinical trial.. you'll have to ask Gilead that question! :)
My doctor uses a better test, but they don't use that one on the clinical trial. They use what Gilead  tells them to use for Gilead's trial

[sorte]

why they don't use some more sensitive test, I think 29 IU is not the best sensitivity ?