My hbsag Status is...

[herinsis]

Hello all

i have found my hbsag positive two years ago. now my hbsag status are as follows:
hbsag =  Positive(250)
hbeag = negative
Hbeab= Positive
HBV DNA= 741 iu/ml

what  should i do, i need medication or not...this stage is inactive or active???
i am going to married what i do??

Please help

[stef2011]

Also do u know any other anti hep B drug will replace Baraclude if people developed resistance to it?
tenofovir or truvada but it is not sure they can suppress hbvdna complitely after etv resistance

the durg with more study on pregnancy is tenofovir, it is also the most potent with no resistance even in case it doesn t suppress hbvdna to und (all other dugs make resistance if hbvdna is detect for long periods)

[tammy_tx2002]

Thanks dear for reply my question, i agree with you since the drug company didn't have sufficient info. for people who is taking it because there were no study done but only on mice/rat. I hope in the future they will find out the answer for all whoever is taking the drug. From now, i just have to use my judgment to decide...Since i have been vaccinated, i am ok and i know my future baby will not be infected by Hep B, but i don't know that it will be affected by the drug since it's category C. Please keep me posted if you have any new info. thanks a lot!

[tammy_tx2002]

It's been like 70% of people we asked told us not to stop taking Baraclude but the 30% said 'we should stop for at least a month, 3 months or even 6 months' . PLus i did all kind of research reading about Baraclude but since the medicine came out only 6,7 years ago, they didn't have enough data to prove that it's safe for baby during pregnancy or not. They only did study on rat/mice only. And plus, i am very about if my husband stopped taking the drug, he will develop acute hepatitis and have resistance which we don't want it to happen.

So we are just trying and don't stop taking the med right? Also do u know any other anti hep B drug will replace Baraclude if people developed resistance to it?

Thanks a bunch!!!

[stef2011]

Can the woman with hbsag and on lamuvudin therapy breast feed the child?

yes but lamivudine is not a hbv drug anymore because it makes hv mutations which make drugs useless and virus more aggressive for liver cancer even blocking hbvdna

as to brest feed i'd avoid that because of the possibility of mutated virus even if child is vaccinated, lam muatted virus can even escape vaccine and be trasmitted to immune/vaccineted persons

tenofovir is the best drug both for pregnancy and for hbv, only tenofovir, entecavir and interferon are approved as first line hbv drugs, all the others are weak and make hbv mutations

[Tankaria]

Can the woman with hbsag and on lamuvudin therapy breast feed the child? Is there any side effect of lamuvudin taking mom on child? bcz my child cries a lot while making water.

[stef2011]

safety issues are only for women, the problem with baraclude is that we have no sufficnet data on women pregnancy,
i think we will find that baraclude is safe for women's pregnancy too in the future since although both entecavir and tenofovir have mild sides entecavir has fewer than tenofovir

[stef2011]

absolutely no problem with men plus he cannot stop antiviral if he gets resistance what will he do?and resistance is probable if h stops

i just read that tenofovir might not be able to fully suppress entecavir resistance.....so he might be left with no working therapy and even if tenofovir can suppress hbvdna to fully und how long will it last without resistance?

[April63]

Baraclude has a C pregnancy rating by the FDA. But this applies to women taking it. It means that there are no conclusive data yet as regarding the safety during pregnancy and breastfeeding. I don't know if the same applies to men. Probably nobody knows that's why you haven't received a certain answer. All the best-April.
P.s.
http://www.drugs.com/pregnancy/entecavir.html

[tammy_tx2002]

my husband has been diagnosed of Hep. B for 3 years, been taking BAraclude for 2 years now. The last viral count was down to undetective level... i just have a short question that now we are trying to conceive, is it neccessary for him to stop taking Baraclude or it's still ok for him to take it? I asked my OBGYN and also the GI doctor but they are unable to tell me. Very disappointed! Thank u!

[stef2011]

no you can monitor and see if you eliminate hbsag but rates are as little as 1-2% naturally
the only therapy you can try is alinia that lowers hbsag especially on hbe negative

antivirals do nothing to hbsag quantity, interferon can lower it but if alt are normal there are poor results and possible heavy sides (it is a chemotherapy), so you won't be prescribed these type of therapy since useless in your case

alinia, a very safe drug used for diarrea even on babies 1 yo, lowers hbsag especially on hbe negative, i do strongly suggest to try it and see if hbsag decrease

alinia have pratically no sides, no resistance and will also make your hbvdna to und in 1-2 weeks

see my posts on nitazoxanide (alinia) and results of our group:
on hbe negative we have seen results immediately in as little as 3 to 5 weeks, decrease of hbsag and hbvdna almost undetctable, hbsag decrease of almost 0.5log

on hbe positive results are weak, very slow hbvdna decline, but we are still in the first 8-12weeks trial and we have seen hbe positive needs 24-48weeks to show results, plus hbe positive on our group are asians with very high viral loads so the most difficult to achieve results

[herinsis]

hello stefano170669

yes my latest hbsag is 250 iu\ml with (hbeag = negative Hbeab= Positive HBV DNA= 741 iu/ml ).

does i need treatment??

[stef2011]

from latest research your state is the only with very high chances of getting rid of hbsag but you have to make sure 250 is in iu/ml unit not s/co or s/n

there is another news fro latest data from vienna congress end of april, you are not inactive hbv but truly inactive carrier with a 8-10% of natural seroconversion by the years to follow, a truly inctive has hbsag<500iu/ml, hbvdna<2000iu/ml, normal alt/ast, f0-f1 liver damage

i do suggest you to try off label alinia (nitazoxanide) because it lowers hbsag and you have high chance of hbsag negative in 1-2 years.also interferon has very high chances of seroconversion but it can have heavy sides too, the good about interferon is that now there is a 12 week stopping rule so you might stop so early if you don't have chances.
for interferon you might try at a research center because normal liver specialist maybe not aware of this data

you might also monitor hbsag,hbvdna for the rest of your life but i do suggest to try something now while you have chances to get rid of hbsag

[gav177]

I'm not married yet, actually I need to find a husband first hehehe who can accept my illness. Your lucky because your future wife accept you. If your wife already completed the 3 shots of vaccine she is protected. What she needs to do is to check her anti-Hbs after the last shot if it is positive she is protected because some people need another series of shots because there body didn't produce anti body from the vaccination. I think your doctor explained it to both of you. If your are healthy carrier some doctor don't advice any anti viral only vitamins in the liver.

[herinsis]

thanks gav177 for your reply

i have already told and we are planning for vaccination before merriage.
can i infect my wife with hepetitis b if we perform unprotected sex after successful vaccination?

one more thing
is there need any treatment in this state?  my AST/ALT is 27/28(normal)

[gav177]

We have the same status. Your hepatitis b is chronic in inactive phase. You can get married but you need to tell your future wife that you have hepatitis b that's why she needs to be vaccinated if she don't have a vaccine for hepatitis B. Honesty is the best policy and you should be responsible carrier.