My healing on peginf

[sorte]

I've started interferon 5 weeks ago, I will try to keep updating in this thread and put related questions here.

week 0:
ALT 30
HBV DNA 700 IU (few months earlier 5600 so fluctuating)
HBsAg 13.000 IU
HBe-
Fibroscan 5,8 F1/S0
Bisopy F1/A2

week 2: ALT 90
week 5: ALT 245

My doctor said last ALT is from one side good (cleaning infected cells) but from other side he's worring that it has raised so fast. I have to check it in two weeks. He said if it will raise to 400 he will decrease peginf dose to 135mcg cuz he's worring that fulminant hepatitis may occure.

[stef2011]

he will decrease peginf dose to 135mcg cuz he's worring that fulminant hepatitis may occure

another doctor with little experience, in pisa even cirrhotics are managed til alt 1000, the danger is over 1000 not 400....

[stef2011]

of course compensated cirrhotics, anyway impressive start

[sorte]

I know Stef, but doctor's dont like when their patients and reputation die :) so they prefer to be cautious. I hope ALT won't rise more and there won't be a need to cut a dose.
Btw, does coffee can cause some ALT increase? There is a study which proved that it boosted peginf response perceptibly in hcv therapies, it also helps liver generally so I would prefer don't cut it.

[stef2011]

i ve always drunk 4 cups a day minimum,i think it is ok

[sorte]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783828/

http://www.ncbi.nlm.nih.gov/pubmed/23238034

they took 3-5 but I can not take more than 2 per day cuz would have sleeping problems :)

[Aduiski]

just found your result...i think you are responding man!
Keep feeding yourself with honey and black seed....

[Aduiski]

...but don't overdose with black seed as it can then be toxic

[Aduiski]

have you been treated before Sorte?

[Aduiski]

Yes do consult with another doctor for ALT values, it would be shame to decrease interferon if decrease is not needed...

[sorte]

I've used black seed before peginf, but for now I've cut some of supplements. it's not good to use too much antioxidoxants during inteferon treatment, althought some are needed.
No, I haven't been treated before. There's no reason to panick, yet ;) I had ALT test in a few days and hope it will be high enough to clear but not dangerous. I will be updating in this thread to keep order.

[Aduiski]

great man...i am cheering that you decrease your HBsAq to bellow 1000, hopefully even bellow 10 IU/ml

[Aduiski]

Do you know what genotype you are maybe?

[sorte]

thanks, it would be great :) No idea what genotype but in Poland 85% is A the rest is D

[Aduiski]

I am really waiting for your week 12 results...when will they measure HBsAg again?

[sorte]

Over 1 month from now and 2-3 weeks waiting for results.

[mustthinkpositive]

What was your ALT just before treatment with IFN?

Looks about right. Mine went to over 200 early in the treatment. Then back down to 185 4 weeks later. Also, those figures were based on 90mcg dosage.

[sorte]

Before it fluctuated from 25-45. Why did you had only 90mcg dosage ?

[Aduiski]

Can you please summarize how you interferon treatment went, from baseline till end?

[sorte]

week 7: ALT 184

So I guess my interferon dose will keep 180 mcg, at least for 2 weeks until next tests :) Although neutrophils are quite low now, 1,00 [2,5 - 7 norm]. Other params almost the same as 2 weeks ago.

[Aduiski]

sounds good sort

[Jatashankar]

Hbsag? Any change or same?

[sorte]

I will have test in the end of October, no sense to do it earlier.

[Jatashankar]

Ya rite, I did my thyroid and hbsag today after 16shots,
Thyroid is normal hbsag result tommorow. 4week gap will show some changes I think hopefully reduction. If no Change I'll shift to peg 2a and see for next 8weeks and then stop if waste response comes.

[sorte]

Good to know that thyriod is ok. I guess most important is result after 24 weeks. If HbsAg wents down than it makes sense to continue.