My healing on peginf

[sorte]

I've started interferon 5 weeks ago, I will try to keep updating in this thread and put related questions here.

week 0:
ALT 30
HBV DNA 700 IU (few months earlier 5600 so fluctuating)
HBsAg 13.000 IU
HBe-
Fibroscan 5,8 F1/S0
Bisopy F1/A2

week 2: ALT 90
week 5: ALT 245

My doctor said last ALT is from one side good (cleaning infected cells) but from other side he's worring that it has raised so fast. I have to check it in two weeks. He said if it will raise to 400 he will decrease peginf dose to 135mcg cuz he's worring that fulminant hepatitis may occure.

[sorte]

ok, got 12 weeks extra and we will see if it makes sense to continue more

[Aduiski]

I don't see why should he continue.

[Aduiski]

but if absolutely no side-effects then it could perhaps make sense

[Raj185]

I think you should continue.
my HBsAg Quant:
Base line:30000
after 48 week(Feb 2016): 9800 (Stopped PegIntf)
after 56 week April: 5400
after 64 week June: 7400

my doctor said the same thing not enough decline we should stop pegIntf. Currenlty continuing on Entacavir.
You should continue and see how it responds.

[sorte]

Recent update, week 46:

ALT: 113
HBV DNA qualitive: und since week 12
HBsAg: 4200 (base 13000 | 7450 | 7200 | 4200)

Probably my doctor won't decide to continue peginf, because too low HBsAg decline, but will try to insist.

[stef2011]

remember that the most effect of pegintf is the second year, since you have an hbvdna response and high alt i assume you might see more on the second year

i remember pisa researcher told me 1 case about the adv+peg add on trial and the patient with the highest response had no hbsag decrease on 1 year of combo, while cleared hbsag and developed the highest hbsab the second year (it was 2 years peg+adv trial)
this is a single case and nothing scientific to apply to all but since no sides and hbvdna response it makes sense to keep it

[Aduiski]

It reduces the severity of the disease...

This was my theory which i got it confirmed recently on my latest appointment with my hepatologist - one of the leading hep b experts in Australia. She has connections with big pharma companies and is involved with a number of important clinical trials regarding hep b, so she should basically know this.

Reduction of the severity of the disease must then, in my opinion, lead to the reduction of HCC risks as well as other negative effects of hep b.

In my opinion, the degree of the reduction of the severity of the disease probably corresponds with the response.

If you want to show some concrete data to your doctor about the prolonged effects, take a look at the Lampertico's presentations on either last year Paris conference or this year Singapore hepatitis conference.
One of his slides comes with the data of hbsag loss up to 20 years after the end of the interferon treatment....thus clearly showing delayed effects of interferon.
While you yourself probably won't be clearing hbsag in next 10 years based on your 24 weeks result, i believe that you will benefit from peginterferon down the road, maybe not to a great extent but benefit should be there as your hbsag is already reduced (and hbsag levels themselves directly correlate with the severity of disease), as shown by a number of studies (you can search for these as well to show them to your doc)