My healing on peginf

[sorte]

I've started interferon 5 weeks ago, I will try to keep updating in this thread and put related questions here.

week 0:
ALT 30
HBV DNA 700 IU (few months earlier 5600 so fluctuating)
HBsAg 13.000 IU
HBe-
Fibroscan 5,8 F1/S0
Bisopy F1/A2

week 2: ALT 90
week 5: ALT 245

My doctor said last ALT is from one side good (cleaning infected cells) but from other side he's worring that it has raised so fast. I have to check it in two weeks. He said if it will raise to 400 he will decrease peginf dose to 135mcg cuz he's worring that fulminant hepatitis may occure.

[stef2011]

the decline is not exactly 1 log but it doesn t matter, what it matters is decline and continuous and that is about week 12 which is not indicative on genotype D hbeag neg...prediction on hbsag loss at week 48 will come from the values of hbsag at week 24

i share your same genotype and hbeag neg, you can be sure i read all studies and statistics on peg mono and it s huge response because you have to take into account:
high baseline hbsag
genotype D, the hardest genotype on hbsag

at this point just recheck the 24week results

[stef2011]

i am just reading it all again:
hbsag week 13 1log decline, from 13.000iu/ml to 7500iu/ml, man this is a huge response not just a little because you have hbeag neg and genotype D the hbsag at week 12 is not even conclusive, for genotype D you need to see decline at week 24 to be sure of response but you had it already and it is 1 log....

[stef2011]

i though it was week 24!if it is week 16th this is a big, huge response....between week 12 and 24 on hbeag neg you even see an increase of hbsag at first and the decline on 24week and on

so please confirm it is hbsag at 16weeks?we may see an increadible response then at week 24, just to compare to other studies in logs you had a 1 log decline at week 16th, if you see 1,5log decline at week 24 we may see very low hbsag by week 48

[sorte]

Thanks for your support guys ! :)
Week 16 results:
ALT 155 similar like before
Neutrophils went up a little to 1,08
Hemoglobin first time a little below the norm.
Rest results no change in compare to prev ones.

[stef2011]

damn so bad we have so many ignorant doctors around, when you see it again tell him he is wrong, tdf need food for best absorption and it is not negligible especially in your case where full potency tdf is needed and might not fully work because etv mutants plus lam mutants can be too much with some secondary mutations

[Tom2013]

Ok,thank you..... actually i got confused because my doc asked my mom to take both the medicines together at the same time in the morning with empty stomach which i think might be risky in empty stmach.....that's why needed to clarify if they can be taken separately at different point of time.