Normal vit D levels are associated with hbsag seroclearance.

[Rome70]

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

[peacefulife]

Hi Dear stef

How are you?

Is the cuban vaccin a theurapetic one or?
Did this vaccin passed all the trials stage?
When is it going to be available ?

Thank you

[stef2011]

dont know if it can work on anybody, i took it few weeks after creatinine increased so very early intervention

[stef2011]

i ve had issues due to my cirrhosis since 2010 and creatinine increased also on etv.i was suggested fibroguard and it made creatinine normal by 1 month so i could use tdf too

[hepbcurepls]

i am interested in the heptech protocol for kidneys. i have a creatinine of 1.3 and was wondering if the heptech will help with it. Were you at 1.2 creatinine before and dropped it to 0.8?

[stef2011]

update on my use of vitamin d:

after taking antibiotics this winter i got a increase of creatinine (antibiotics are toxic for kidneys and some brand may even lower creatinine clearance while on it, it happened to me), this is not resolving with creatinine 1.2 high range of normal.since also tdf is toxic on kidneys with damage i will stay off vit d for one month and restart full heptech protocol to make it as before antibiotic use 0.8

i hope hbsag will at least stay stable around 800iu/ml but anyway with cuban vaccine close to available this year and rep9ac advancement and my low hbsag i think i need not to worry about hbsag anymore

[pong58]

Ty stef