serology

[heavyworld]

hbsag elisa -reactive
anti hbs-non reactive
hbeg ag-non reactive
anti hbe-reactive
anti-hbcG-reactive
anti -hbcM-non reative

pls someone  especialist explain my profile and wat shud i do" tnx

[heavyworld]

thnk q very much in ur info,,

[cajim]

You have HBeAg- HBV.

Are you taking the conventional, Western-medicine route or some other route?

If the former, according to AASLD Hep-B Guideline 2009 Update,

If you are HBeAg+, HBV DNA (PCR) >20,000 IU/mL ALT 40 years, ALT persistently high normal-2x ULN, or with family history of HCC.  Consider treatment if HBV DNA >20,000 IU/mL and biopsy shows moderate/severe inflammation or significant fibrosis.

If you are HBeAg+, HBV DNA (PCR) >20,000 IU/mL ALT >2 x ULN, then, observe for 3-6 months and treat if no spontaneous HBeAg loss.  Consider liver biopsy prior to treatment if compensated.  Immediate treatment if icteric or clinical decompensation.  IFNa/pegIFNa, LAM, ADV, ETV, TDF or LdT may be used as initial therapy.  ADV not preferred due to weak antiviral activity and high rate of resistance after 1st year.  LAM and LdT not preferred due to high rate of drug resistance.  End-point of treatment – Seroconversion from HBeAg to anti-HBe.  Duration of therapy: IFN-a: 16 weeks;  PegIFN-a: 48 weeks;  LAM/ADV/ETV/LdT/TDF: minimum 1 year, continue for at least 6 months after HBeAg seroconversion; IFNa non-responders / contraindications to IFNa -> TDF/ETV.

If you are HBeAg-, HBV DNA (PCR) >20,000 IU/mL ALT >2 x ULN, then, IFN-a/peg IFN-a, LAM, ADV, ETV, TDF or LdT may be used as initial therapy.  LAM and LdT not preferred due to high rate of drug resistance  ADV not preferred due to weak antiviral activity and high risk of resistance after 1st year.  End-point of treatment – not defined.  Duration of therapy:  IFN-a/pegIFN-a: 1 year; LAM/ADV/ETV/LdT/TDF: >1 year; IFNa non-responders / contraindications to IFN-a -> TDF/ETV.

If you are HBeAg-, HBV DNA (PCR) >2,000 IU/mL ALT 1- >2 x ULN, then, consider liver biopsy and treat if liver biopsy shows moderate/severe necroinflammation or significant fibrosis.

If you are HBeAg-, HBV DNA (PCR) <=2,000 IU/mL ALT 2,000 IU/mL—Treat, LAM/ADV/ETV/LdT/TDF may be used as initial therapy.  LAM and LdT not preferred due to high rate of drug resistance; ADV not preferred due to weak antiviral activity and high risk of resistance after 1st year.  HBV DNA6 months; 2. Serum HBV DNA >20,000 IU/mL (105copies/mL), lower values 2,000- 20,000 IU/mL (104-105 copies/mL) are often seen in HBeAg-negative chronic hepatitis B; 3. Persistent or intermittent elevation in ALT/AST levels; 4. Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation.

Inactive HBsAg carrier state: 1. HBsAg-positive >6 months; 2. HBeAg-, anti-HBe+; 3. Serum HBV DNA 20,000 IU/mL after a 3-6 month period of elevated ALT levels between 1-2 ULN, or who remain HBeAg positive with HBV DNA levels >20,000 IU/mL and are >40 years old, should be considered for liver biopsy, and treatment should be considered if biopsy shows moderate/severe inflammation or significant fibrosis. Patients who remain HBeAg positive with HBVDNA levels>20,000 IU/mL after a 3-6 month period of elevated ALT levels >2  ULN should be considered for treatment.
HBeAg- patients:
● HBeAg-negative patients with normal ALT and HBV DNA <2,000 IU/mL should be tested for ALT every 3 months during the first year to verify that they are truly in the “inactive carrier state” and then every 6-12 months.
● Tests for HBV DNA and more frequent monitoring should be performed if ALT or AST increases above the normal limit.

[stef2011]

the test you have done are useless in terms of disease activity, they only say you are infected, to see disease activity you must check hbvdna pcr, alt/ast every 6 months and then in case of active disease biopsy or fibroscan to see liver damage

so do check regularly hbvdna pcr and alt/ast and you will know something about the disease

[heavyworld]

drs a chnge to overtake the COV? accrdng in my dta...

[cajim]

Your question?

[heavyworld]

To: hep prof              pat val.                 cov
hbsag elisa -reactive  3.816                  0.105
anti hbs-non reactive  0.020                   0.105
hbeg ag-non reactive   0.013                 0.105
anti hbe-reactive            0.040             0.828
anti-hbcG-reactive       0.042              0.434
anti -hbcM-non reative  0.20              0.105
   this is my value results..
  i dnt tstd d ALT AST and i dont knw dt,. my parents is non reactive only me. IM NOT SMOKER,ALCOHOLIC, AND NO SYPTOMS., IM PHISICALY FIT BT D HBV REACTIVE,, WT CN U SAY

[cajim]

wat shud i do

--Have you tested your ALT AST?  Do you have symptoms?  Depending on you, you may choose Western medicine route or a life style change route.

[heavyworld]

hbsag elisa -reactive
anti hbs-non reactive
hbeg ag-non reactive
anti hbe-reactive
anti-hbcG-reactive
anti -hbcM-non reative

pls someone  especialist explain my profile and wat shud i do" tnx