HBV Clearance Data - HsAg lost

[Ann8]

Natural Immunity - ~1%
Tenofovir - ~3-5%
Peginterferon alfa-2a - 3% 1st yr, 6% 2nd year, 8% 3rd year, 11% 4th year after 1 year course.
Entecavir - 0%
LDV - ??
ADV - ??
Combo - ???

Depressingly low success rate, look like we need a completely new & better way of treating this monster -something to clear viral cccDNA & enhance immune + antiviral might give us chance. Otherwise, w/ antiviral alone this will continue to be a no cure scenario....maybe NUC B1000 or cloned genetic or stem cell! Any comments?

[stevenNYer]

"It is what it is."

Couldn't agree more.  That's why it's best to hold expectations in check.  Life continues...enjoy it.

[zellyf]

I have to admit that I've never chased the idea of a cure.  I won't be finding one myself and I don't think it will be a priority for medicine given the fact that there is a vaccine.  Economically, it doesn't make sense to pour a lot of money chasing a cure for a disease that there's a chance could be eradicated  in 2 or 3 generations.  I suppose this might be a depressing thought but I'm pretty neutral about it, actually.  It is what it is.

My thoughts are that a cure, if found, would be found by way of researching some other virus.  HIV or HCV, perhaps, where vaccines are not available.

My focus is on treatment and battling resistance.

[cajim]

The percentages are low.  Hopefully future new medications or new types of treatment will change that.  There is always a future and the percentages can only go up.