Results after 44 weeks of TDF+Peg+NTZ

[April9903]

In March 2012 (Before Treatment)
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HBV DNA --  450,897 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
HbeAg  -- Neg
AntiHbe -- Pos
Fibroscan =  4.2 Kpa
Geno Type C
Precore BCP ( T 1762 / A 1764 ) Mu
PC codon 28 Mu


22-October 2012 (After 12 weeks of PEG + TDF + NTZ )
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HBV DNA --  186 copies/ml
HBsAg (Quantitative) --  2869.70 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --61.3 ug/l
ALT - 81 u/l
AST - 89 u/l
Platelet Count is low - 140


31-December 2012 (After 24 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2606.72 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   46.1 ug/l
ALT - 52 u/l
AST - 63 u/l
Platelet Count is normal - 150
Fibroscan =  6.1 Kpa

15-May 2013 (After 44 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2612.48 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   54.8 ng/ml
ALT - 84 u/l
AST - 80 u/l
Platelet Count is normal - 177

Last week, I had the last shot of Peg. I am very disappointed with my HbsAg results. It's not going down anymore. Doc said the effect of Peg will stay on very long even after the last shot. I continue taking TDF but stopped NTZ now. My Alt and Ast is also still high. Very disappointed!

[stef2011]

lampertico is doing many studies and the add on study after longterm nucs is his too

peg+nuc immediately work well on hbe+ but much less on hbe-, the add on sequantial treatment is the way to go

[calebz]

April recheck that Fibroscan result.

[April9903]

Thank you all very much for your support . I am feeling a bit down at the moment. Throughout the tx I lost a lot of hair and had flu like symptoms and tiredness, wired headaches, sometimes more, sometimes less. I used paracetamol when I cannot stand it anymore but I tried not to use it often.

@celebz..I am very encouraged to know that "IFN will help despite the HBsAg result, there are studies that it lowers HCC risk a lot despite no SVR."

[Jeff912000]

Sorry.  I have to take back the last sentence about not needing any painkillers.   I am not sure whether she took more medication than panadol for the side effects.  

[Jeff912000]

Everybody should have one try with interferon just in case they are lucky reponders. I remember Steff also said this before.   I did not recommend April to do the combo.  I also think she should do serial treatment.  But just giving her support.  It is kind of her to share her treatment experience.  I do not think April needs any painkiller for her PEg.  

[calebz]

You are wrong, there may be some nephrotoxic sides if you add painkillers people use to cope with IFN side effects. Remember not everybody handles IFN the easy way.. some have strong fevers/flu effect.  It would be perfect of you link a study result to what you say about combo results. I think that most options on combo treatments here are based more on theory rather than actual med trials. Gilead is currently running a combo trial of IFN/TDF and results will be available around 2015. Its too bad they don't have a sequential arm just combo combinations. I think that what stef does has more sense than a combo: keeping TNF for a few years and then starting IFN.