Sci-b-Vac shippment solution from israel

[Soflab]

Hi all,

Please find attached reply from Mr Ron from Isramed.
The question to Mr Ron was could the Vaccine be shipped to Casablanca, Morocco?

Reply from Mr Ron

Thank you for your interest in IsraMeds.

Sci-B-Vac is available and can be sent to Casablanka, Morocco by cold chain shipment(refrigerated all the way and not in bags)

Sci-B-Vac is available as 2.5mcg / 5mcg / 10 mcg. Prices start from $77 per ampule to $297 for the 10mcg ampules.

There is a 15% discount if you decide to purchase the 25 ampules original package.

Please note you must calculate 3 doses per person meaning that 12 ampules would be enough for 4 individuals.

Please specify the dose, quantity and prefferance of shipment method and I will gladly quote you prices and ask our accounting dept. to prepare a proforma invoice for your purchase.

Also please reply with you telephone number so I can explain the details...

Kind  regards,
Ron Fischer




More question pending reply:( from soflab to IsraMed Mr Ron)

Could you please relay the list of countries you can ship this SCI-B-Vac.
As i am a member of www.medhelp.org (soflab) hepatitis B Forum, lots of members all over the world want to try this vaccine for the sake of the Forum trials could you relay what would be the price for our members in medhelp.

[stef2011]

very very good this is surely needed for those with extremely low hbsag or those who cleared hbsag after pegintf but not developped hbsab

wow this could be good for us members but also for Sci-b-vac they might end up with free human trials on chronic carriers because we can gather all tests

[stef2011]

please let s check if some european countries is allowed too

[stef2011]

does it make any sense to try this vaccine during pegintf or for those with very low hbsag levels with monthly injections in a skin area previously treated with imiquimod (with also zadaxin added for the lucky ones who has it), the vaccine seems inexpensive and if it makes no harm it would be a good try

are there any trials on these new hbv vaccines in combo with peg intf and zadaxin, i couldn t find any?

thanks

[veteranB]

Stefan. I spoke with the guy from Scicore. He is saying taking zadaxin plus any nuc for six months to a year has 80% success  for just about anybody.

Japanese were doing vaccines with immune simulators before. It helped some people. Probably you are right those with low surface antigen.

Although some people say it does not really matter how high your surface antigen or dna is. Its about how good the immune system is.  

[studyforhope]

An intradermal injection into an IMIQUIMOD pretreated area as adjunct therapy makes sense. But it would be so much better, if it also contained core particles. Simultaneous thymosin alpha, as shown in the Canadian trial is also likely to help. That trial, used to stabilize seroconversion, used only the monovalent, not the triple antigen vaccine.

[newtr]

please give more details, so we can learn about it better.

[Rome70]

You have mentioned earlier that even with very low hbsag quantity even at the limit of detection of 0.05 iu/ml we still have millions of hbsag particles per ml. Vaccine shot would just increase the number of these particles , so why vaccine should help to develop antibodies? In fact blood of a person with hbsag and zero VL is vaccine itself... I am speaking about monovalent vaccine.
Thank you for you great assistance to this community!

[studyforhope]

You are correct, indeed many years ago the first vaccines were made from patients blood, after inactivation of the virions. These vaccines were actually much more potent than the later recombinant ones, they did contain pres1 and pres2 components and the denatured virion remnants certainly helped as well. Robert Neurath based his famous paper in in the journal nature showing "a strong T cell response to pres1 in man" on the study of such vaccinees.

If an effect of therapeutic vaccination in borderline "pushover" situations can be expected, then only because a strong adjuvant is simultaneously present in the application or at the application site, like cpgODNs in the dynavax vaccine, or thymosin alpha, or the super antigen HBV CORE PARTICLES or maybe IMIQUIMOD and the presence of all three surface antigen types S. M. and L.
It is the activation of the local dendritic cells that determines the quality and quantity of the immune response to any vaccine.

The regular recombinant S only vaccine will have no effect, the alum used as an adjuvant is too weak and does not stimulate T cell responses.

[Rome70]

Many thanks for your comments !
Could you also please comment on vit D supplementation? There are many studies that prove that vit d stimulates innate immunity and down-regulates the adaptive one, does it mean that vit d supplementation should be stopped on the stage when hbsag is low and you expect the hbsab to come up?  

[Rome70]

For ex in this case with therapeutic vaccine from israel.

[studyforhope]

There is no good answer to the question of vit D intense supplementation effect on the stages of spontaneous or induced hbsag seroconversion.
I would remain in the range between 60 and 80 until clear evidence emerges to suggest otherwise.

[StephenCastlecrag]

My understanding is that Sci-b-Vac is a prophylactic vaccine, but you seem to imply that it can be made to be therapeutic by using it together with potent adjuvant?
Sci-b-Vac contains in addition to the s antigen, the preS1 and preS2 antigens, is thought to be more expensive to produce, hence its smaller share of the market.
Is it the presence of the preS1 and preS2 that makes the difference? But doesn't the HBSag sub viral particle also has preS1 and preS2?

[studyforhope]

The recombinant monovalent vaccine S particles, derived from yeast as in engerix, do not contain any trace amount of the pres extensions of the S protein. they also lack certain  processing signals, that might be important in immune recognition, like carbohydrates, that are present in the production from chinese hamster ovary cells.

The natural 22nm surface antigen particles contain very small amounts of preS2 and extremely small amounts of preS1.

In HBV serum also exist so called filaments, which are elongated S-particles, they contain a small percentage of preS1. The filaments only  comprise a small portion of all the particles.

So it might make some sense to concentrate these antigens on an activated local area of entry tissue, like the skin, onto adjuvant activated dendritic cells. Circulating particles are not very immunogenic, since they have already penetrated the natural barriers where the immune response gets started.

The reason for the small amount of market shares for the Israeli vaccine is not the higher production cost, but simply the overwhelming cost of getting it approved outside of Israel.

And yes, it is not a therapeutic vaccine. But if properly adjuvanted, it seems to qualifiy as a first choice if one has to use currently licensed vaccines in combination with an additional adjuvant, due to its extra antigen content, that is likely quite important in the enhanced response repertoire.

And one must stress that its effect, even when adjuvanted as discussed above,  will still be small, maybe able to push a slow natural seroconversion into a stable phase.
I am afraid that this will still be true even for the new planned therapeutic vaccines.

[Soflab]

POSIBILTY TO BE DELIVERED THE SCI-B-VAC in Madrid Spain. I will copy and paste all the replys from ISRAMED. Please let me know any member in europe willing to have the Vaccine that i can included to my 6 doses to be delivered on the same date 18th August TBC.

[Soflab]

Dear Ms. Soufiane Labsy

Thank you for your reply.

The price for 6 ampules would be $297*6*0.85 = $1514.70 + Delivery Charge.

We are looking into the preffered delivery option and will update you shortly.

There may be an option that we meet you on your connection in Europe(Madrid for example) on the 18th or 19th and hand deliver it to you, this could save you some time effort and moneywith beurocracy at the Morocco customs especially as this is coming from Israel.



Kind Regards

Ron Fischer

[Soflab]

Subject: RE: IsraMeds booking flight to Madrid

Dear Ron,

Thank you for you prompt email and making this delivery in an efficient way by proposing Spain Madrid.
You sound like you have a better understanding the Moroccan customs since it was my concerned if DHL or FEDEX will be able to transport medecine to Morocco. Not only this but also to send foreign money you need special permission from Rabat capital city and here again time consuming.

So the Solution is Madrid and since i am Cansdian holding a Canadian passport it should not be an issue. I found a flight Casablanca leaving on the 18 August @1555 arriving to Madrid Barajas Ter 4s @ 1835. The return ticket is on the 19 th August @ 2015. So i need your confirmation that the Vaccines have to be delivered to myself on the 19 August between the hours 0800 to 1700. Also where to meet it will be idle next to the Airport if not in the airport itself. So please confirm this and i will go ahead with the airfare booking and i will send a copy of the booking proof of me showing up at appointment for collection.

Thanks once more and i hope that we can work in the future for the members of medhelp and being able to make their life easy by giving them the chance to get hand on the SCI-A-vac since it is concidered the most valuable vaccine but unfortunately only comercialised in Israel. Also i already posted Mr Ron reply to the medhelp members for possible shippment so you should be hearing soon for these guys. After research j understand that the company owning this Vaccine had open an office in Madrid for future potential sales in europe afterghe vaccine will get EU approval any news in this regards?


Awaiting your go ahead for booking my flight to Madrid.

[Soflab]

We cannot purchase the medicine and our rep's flight tickets without having the money in our bank account.

The fact that we are shipping this from Israel to Madrid with a messanger causes the shipping charge to be higher. On the 18th a ticket costs $790.

I can confirm that our rep will be able to meet you on the 18th in Madrid depenable on prior payment.

Please send us the wire transfer payment papers after receiving them from the bank.

[Soflab]

Stef please be advised that i have one Connection a Fiend of mine  in Telaviv he will be checking the exact price for the Sci-B-Vac from a walk in pharmacie in isreal and i beleive that the price should be 50% or more less than the 297usd through an online pharma in israel. i will update on this as soon as i get an answer from my friend.

[stef2011]

infact all the ting looked very expensive, i though the vaccine was about 77usd.....

since we dont know if the vccien works therapeutically it would be best to wait for approval in europe or just purchase in case of very low hbsag or after pegintf

the idieal use would be:
48weeks of pegintf (any type, mono, sequential/combo with nucs)
if hbsag is low at 48weeks like less than 500iu/ml try the vaccine with imiquimod cream on site of injection

my guess on vit d is that it improves response by antimicrobial production making it very high levels but we dont know how it worls with vaccines.
there are of course few studies on low ranges like less than 10ng/ml with less response to vaccine but there is no study on the very high levels like 100-165ng/ml so better stay with studyforhope suggestion less than 100ng/ml

[Soflab]

Hi Stef,

Could you give me more info on the figure low 10ng/ml and high 100to 165 ng/ml how and what test to prefom to check them are they related of Vit d content on the bolld?

[stef2011]

first have a abseline test of d25oh, then start taking vit d3 10.000iu daily and vit k2 400mcg daily, if you but d3plus from biotech it has already k2 in it and pills are 5000iu so you ll have to take 2 pills daily

avoid all diaries products (milk, cheese and so on) and check monthly d25oh, serum calcium and ionised calcium

when you reach about 100ng/ml lower to 5000iu daily and see if it stays, also check yuour baseline hbsag quantity and retest after 3-4months on serum levels 100ng/ml to see if it has any effect on hbsag

[justanotherguy2013]

what is this Sci-B-Vac...? can we develop antibody from this..

[newtr]

please clear whats going on about this vaccine.

[Soflab]

we think it is worthwhile for people having lesss HBV load to go ahead and try this vaccine Sci-B-Vac  there is no harm of doing so if not beneficial.
So to my understanding and stef can correct me if i am wrong,

(An affected person readings should show the following= less HBV load)

-Hbsag: pos
-Hbsab: pos is favorable but even with neg can try to use the vaccine since the aim is to boost anti bodies and get them to work proparly.

-Hbe ag : neg
-Hbe ab: pos

-HBV DNA: less than 1000 iu/ml
-Hbsag quant: less than 1500iu/ml genotyp A or D
100iu/ml genotype Bor C steff could you correct please if i am wrong.

-Hbcigg: pos
-HBc Igm= pos=accute no harm if this latter was neg = chronic to try vaccine

-double check vitd level if low try to get vit d3+vitK2 or vit D plus to achieve 100ng/ml