Sudden Increase in ALT/AST after stopping Ntz and LIv 52 HB increases HbsAg

[smile_boy]

Hi Stef and Others,

There is a sudden increase in my AST and ALT values after stopping Ntz. I stopped Ntz in August 2011 end and later I started taking Liv52 HB.

Results on Feb-2012:-
ASPARTATE AMINOTRANSFERASE (SGOT )PHOTOMETRY =98.00 U/l M: 0 to 37 - F: 0 to 31
ALANINE TRANSAMINASE (SGPT) PHOTOMETRY = 244.00 U/l M: 0 to 37 - F: 0 to 31

ALKALINE PHOSPHATASE PHOTOMETRY =98.30 U/l M:53 to 128 - F:42 to 98
BILIRUBIN -DIRECT PHOTOMETRY =0.26 mg/dl 0 - 0.3
BILIRUBIN - TOTAL PHOTOMETRY= 0.85 mg/dl 0 - 1.2
BILIRUBIN (INDIRECT) CALCULATED =0.59 mg/dl 0 - 0.9
GAMMA GLUTAMYL TRANSFERASE (GGT)PHOTOMETRY =21.00 U/l M: 0 to 50 - F :0 to 30
PROTEIN - TOTAL PHOTOMETRY =8.30 gm/dl 6.0 - 8.3
ALBUMIN - SERUM PHOTOMETRY= 4.56 gm/dl 3.2 - 5.0
SERUM ALBUMIN/GLOBULIN RATIO CALCULATED =1.22 Ratio 0.9 - 2.0
25-OH VITAMIN D TOTAL= 37.26 ng/ml
HbsAg Quant - 1789 iu/ml



Results on Aug -2011:-
SGOT - 25.90
SGPT - 38.90
HbsAG - 733 iu/ml

Almost SGPT has increased 10 times. Kindly help me. I'm very scared about my situation. If stopping ntz increases ALT ans AST ,we cannot take ntz for life long? please help

[studyforhope]

Full sequencing would be necessary to detect this kind of mutations.
Tenofovir will work to suppress even those.

[smile_boy]

Hi StudyforHope.

Thanks for the reply. Please let me know is there any way to detect mutants?

Tenofovir can tackle the mutants?

[studyforhope]

It looks like you have a mutated form of surface antigen, that escapes proper quant measurement.
I would use tenofovir to suppress future flares. These flares can accelerate development of fibrosis and cirrhosis.
Fibroscan or liver biopsy are needed to determine your current fibrosis status.

[smile_boy]

Hi Sudyforhope , Stef and stephen

Please find my QhbsAg and HBV DNA


BLOOD - SEROLOGY
:‎
HBsAg - QUANTITATIVE  : 83.00 IU/mL  Less than 0.05 IU/ml : Negative
Method : CLIA - ARCHITECT
:‎

HBe  Ag  : NEGATIVE‎
Method : CLIA
MOLECULAR BIOLOGY

HBV VIRAL LOAD BY REAL TIME PCR : 35‎,‎24‎,‎213 ‎IU‎/‎mL ‎( ‎6‎.‎54 ‎logs‎)

The test is done on Roche COBAS TAQMQN ‎48 ‎Real Time PCR ‎
Analyser‎

DNA is very very high.

What I should do? Tenofovir or entecavir ? Which is good for this high viral load ?

Please reply. any possiblity of liver Fibrosis or cirrhosis?
:

[StephenCastlecrag]

I think there are links between serum iron parameters and chronic hepatitis. It is quite a complicated area, I believe. Best to consult your doctor.

[stef2011]

iron content is increased in infections and it helps viruses to replicate, proper vit d levels are reported in several studies to help make it normal

there is also liver damage due to iron overload but i am not expert on this and you d better refer to your doctor, although levels dont look so high