I know anti-viral drug can reduce the cccDNA, but can not clear them all. That is why after long time antivirus therapy treatment, when you HBVDNA negtive and HBeAg - and HBeAb +, you can still chance to get relapse.
Adevofir 5 yrs treatment, 1/3 people relapse after stop Adv.
Enticavir will have less resisitance like adv.
More new drug like TDF,ETC,etc.
New research told us that HBsAg has some relationship with cccDNA, so doc use HBsAg quantitive measurement as a benchmark for the efficacy of anti-viral treatment. Like new drugs, NTZ, REP 9AC, etc....
So my question is if we can get the HBsAg lower to a undetectable level, is it means cccDNA is eradicated at all. How can we tell when it is the final point?