Viread & pregancy

[worrriedwife2010]

My husband is currently taking Viread for HepB and his doctor told us that there is a 5-6% chance of birth defects if I become pregnant. Has anyone heard this before? I see that women who are the ones taking the med take it while pregnant so I'm a bit confused/hopeful.

[stef2011]

wow, thanks for this increadible, on hbv it is not 300fold more potent but only 4.5-fold but on hbv tdf has already no resistance, so this will make it the final drug for hbv over entecavir for both potency (it is already more potent than etv) and less toxicity

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043283/

i hope it will get the market before tdf patent expires in 2015....

[ytdthjznyj]

http://www.chimerix-inc.com/news-and-resources/news-and-resources-details/chimerixs-cmx157-shows-potential-to-treat-multi-drug-resistant-hiv-and-impr/

is it improved tenofovir?

[enolia]

Also, see this

http://www.natap.org/2010/HBV/HBVdtherapy.pdf

[enolia]

Hi,

I am pregnant (28 weeks) and taking Viread. I did many researches and my dr insisted that it was the safest antiviral for pregnant women, it is #1 to consider when you are pregnant. It has also been tested by HIV and HBV women and it hasn't caused any harm to fetus (birth defect rate not more than normal population = under 3%) I don't know where your dr got 5% from!
Tenofovir is category B for pregnancy so it is safe and certainly safe than entacavir which is category C (proved to be harmful to fetus). Good luck.

[stef2011]

forgot about pregnancy.......entecavir hasn t enough data even though probably safer than tdf, so probably best choice is start with tdf and only if gfr lowers below 60, which won t probably happen, switch to entecavir

[stef2011]

in case of decline of gfr below 60 or 30, since renal failure is when gfr is below 15, tenofovir can be reduced to 150mg daily or 75mg daily and still fully active.at lower doses the drug still works even in case of lamR, i posted a study a couple of days ago on this who last 5 years without any tdf resistance, both doses are much more potent than adv

since only 1% needs to change dose due to low gfr below 30 it is better to keep full dose even if 150mg and 75mg work.

to avoid any type of side it is better to start with entecavir like i did but resistance test must be done because entecavir doesn t work in cause of lamivudine resistance mutations

[cajim]

Be cautious with TDF:  " A significant though moderate decline in the renal function was observed in one-third of the patients receiving TDF compared to patients not receiving TDF."

Thank you, ytdthjznyi.

[ytdthjznyj]

http://www.ncbi.nlm.nih.gov/pubmed/20854202

[stef2011]

since i have cirrhosis i may have to combo entecavir and tenofovir if i fail to eradicate hbv by entecavir+alinia or entecavir+alinia+interferon combos, so i am very aware of viread (tenofovir) sides and how to avoid them

[stef2011]

it has no sides, only less than 1% experience lowering of gfr so kidneys function must be controlled every month for the first 6 months of therapy to see if kidneys experience a decrease in gfr (creatinine is not good because you can have lower kidnys function and normal creatinine), other sides is loss of bone mineral density but if you have active hbv even liver damage leads to loss of bone mineral density and lower vitamin D

since this is only on less than 1% cases almost every drug can lower gfr on more than 1% cases

NAC a strong antioxidant can preserve kidneys function even in those who gets a decrease of gfr, it also improve liver function.gfr must reach values lower than 60 to start worring about it, values between 60-95 are present in general population but have no synthoms and no particular concern, normal optimum values gfr is >95.Gfr lowers naturally aging so according to age a low gfr is normal

to preserve bone mineral density both on viread or not, vitamin d in the blood must be checked since more than 95% hbvers have deficent vit d and bone density after many years with cronic hbv, sun or supplements must be used and blood levels checked every 4-6 months.vit D levels have been changed in latest years to 50-60ng/ml, i took both supplements and sun but could not reach more than 47ng/ml whatever the dose

[bruja86]

i am going to start the medication viread i am so worry about the way i will fill from side efect is any body give me more inf...thank you

[stef2011]

absolutely fine no danger at all, and your husband cannot stop viread anyway because every very dangerous
many women memebers infected with hbv in the community are taking viread both to cure hbv and prevent transmission to baby

if you browse the community you will find that there are many ignorant/superficial liver specialists prescribing old dangerous drugs and making mistakes
even me met a gastroenterology spicialist who is ahead of gastroenterology in one of the biggest and most important hospitals but end up with cirrhosis because of his mistakes
now i trust only my knowledege on hbv and one of the most advanced researchers team on hbv in the world nobody else

[worrriedwife2010]

I'm just relaying what we were told. The doctor is a respected Hepatitis specialist in my city and I can't understand why she would tell us that if there wasn't some truth to it.

But again, if pregnant women are taking Viread and having healthy babies, I should be fine, right?

[stef2011]

what an ignorant, is he really a doctor or he thinks your husband is giving birth to a baby....

no defect ever happened on viread until now when the mother is taking the drug, the father has nothing to do with the pregnancy and his seamen has nothing to do with the drug