Aa
What can i Do
Hello every one!
I'm from Albania! This is my history: In sepember 2010 I have the result: Alt 420 IU, Ast300 IU, Hbeag Negative, hbv-dna 2.6x10^5 IU/ml. Immediatily I was put on interferon (roferon A 3 times weekly) for one year till october 2011. After 6 month off treatment (march 2012) my Alt 42 IU, Ast 35 IU, hbv-dna 1.4x10^4 IU/ml, Hbsag 1080 IU/ml. On March 2012 Hbsag 960 IU/ml, Alt 40 IU Ast 30 IU. Today after 2 years and half after the end of treatment (march 2014) Alt 41 IU, Ast 30 IU Hbasg 747 IU/ml, Hbv-dna 4.0x10^4 IU/ml, Fibroscan (7.5 kpa) F2 (for the first time) . During this time I,m taking 5000 IU vit. D every day. Doctor told me to treat with tenofovir, because your fibroscan is F2. I ask him to treat me with interferon, because I thougth that my hbsag is declining and is <1500 IU/ml., and doctor said ok , but we have to wait 1 month for interferon, because it will be delivered to hospital.\
My question is : Is my decision good to go for second time for interferon or to treat this time with tenofovir? The first time of interferon was terrible, but I want to be cured, not to be on tenofovir for all life.
Any suggestion Steff Ti prego!
I'm from Albania! This is my history: In sepember 2010 I have the result: Alt 420 IU, Ast300 IU, Hbeag Negative, hbv-dna 2.6x10^5 IU/ml. Immediatily I was put on interferon (roferon A 3 times weekly) for one year till october 2011. After 6 month off treatment (march 2012) my Alt 42 IU, Ast 35 IU, hbv-dna 1.4x10^4 IU/ml, Hbsag 1080 IU/ml. On March 2012 Hbsag 960 IU/ml, Alt 40 IU Ast 30 IU. Today after 2 years and half after the end of treatment (march 2014) Alt 41 IU, Ast 30 IU Hbasg 747 IU/ml, Hbv-dna 4.0x10^4 IU/ml, Fibroscan (7.5 kpa) F2 (for the first time) . During this time I,m taking 5000 IU vit. D every day. Doctor told me to treat with tenofovir, because your fibroscan is F2. I ask him to treat me with interferon, because I thougth that my hbsag is declining and is <1500 IU/ml., and doctor said ok , but we have to wait 1 month for interferon, because it will be delivered to hospital.\
My question is : Is my decision good to go for second time for interferon or to treat this time with tenofovir? The first time of interferon was terrible, but I want to be cured, not to be on tenofovir for all life.
Any suggestion Steff Ti prego!
I,m 33 years old and I want to correct hbsag 960 IU/ml was on march 2013 not n march 2012. For 2 years and half I,m not on any treatment , only vit.D3 5000 IU/ml and fish oil every day,
Please guys any suggestion about my retreatment? Which drug would You choose tenofovir or Pegasus in this case?
Definitely your decision. Go for the chance of a cure. TDF might do the job as well.
When you said terrible while on IFN the first time, what do you mean? Inconvenience, tiredness?
When you said terrible while on IFN the first time, what do you mean? Inconvenience, tiredness?
Hello mustthinkposite! Thanku You for your response.
When you said terrible while on IFN the first time, what do you mean? Inconvenience, tiredness?
Every part of my body hurt, my hair fall and did not grow back . I was very nervous with every body. I lost 15 kg and I gain only 5 kg after interferon. My live changed, I thing now I am an other person. I am very depressed, not happy guy anymore. About tiredness I was not, even never got flu for 2 years. Only my legs even now hurt, they burn. I was changed like a victim, people did not even regnozise me. I work in the office, but was very hard to do something, I was not concentrated. About interferon I am happy only about one thing: my hbsag is declining. I never did this test before treatment, only after and was 1080 IU/ml, and now after 2 years and half is 747 IU/ml.
Do think I have a chance to go again for Pegasus, or better to go for tenofovir? I,m afraid that maybe again my sacrifice will not be worth.
Any suggestion.
When you said terrible while on IFN the first time, what do you mean? Inconvenience, tiredness?
Every part of my body hurt, my hair fall and did not grow back . I was very nervous with every body. I lost 15 kg and I gain only 5 kg after interferon. My live changed, I thing now I am an other person. I am very depressed, not happy guy anymore. About tiredness I was not, even never got flu for 2 years. Only my legs even now hurt, they burn. I was changed like a victim, people did not even regnozise me. I work in the office, but was very hard to do something, I was not concentrated. About interferon I am happy only about one thing: my hbsag is declining. I never did this test before treatment, only after and was 1080 IU/ml, and now after 2 years and half is 747 IU/ml.
Do think I have a chance to go again for Pegasus, or better to go for tenofovir? I,m afraid that maybe again my sacrifice will not be worth.
Any suggestion.
Hello there .i hope u doing well..please can u tell me were did u do the hbsag test..did u do it in Albania or u when out of country..I m from that part so I wanted to go for that test..thanks and I hope u cure ...
Hello Seka! The hbsag test (called Hbsag Quantity, cost around 33 euro) I did in Albania, in Tirana. The name of laboratory is Intermedica, is well known in Tirana. They used ellyses, not Architect Abort, but I think is the same thing.
6/10 patients have loss of HBsag when they use long term NUCs and add peginterferon on. Read this website from Denis Ouzan. http://www.aphc.info/pdf/2014/Luncheons_13012014/S-242A/Denis_OUZAN.pdf
Elis don't think that you have to take your antiviral for all your life. The cure is on way,for few years will be out. Cure for hep c is already out, now the interest will focus on hep b, and already there are discoveries. For now the best cure 60% is tenofovir for 2-3 years and later on peginteferon. You need to low your viral load, while your hbsag is a good number to get a chance to clear it.By the way,here in USA we don't have the possibility to know about the quantity of Hbsag, I am planning to come this summer in Balkan. Where in tirana is located Intermedica?
Hello mer971! Intermedica is in front of the train station of Tirana. It is almost in the center of Tirana. The phone number of this laboratory is 0035542274662.
you have now the highest chances to clear hbsag and make hbsab, even if you will not clear by 48weeks hbsag will be so low to continue the clearance by your immune system
tenofovir cannot help in this, so i would not use it
be sure to have good levels of vitd like 60-80ng/ml before starting peg, i believe it can help a little in lowering inflammation, it also boost peg repsonse because it activates genes involved with intf pathways (a research a read recently).sides should be much less, many report less sides on peg with low hbsag, usual sides at start but less when hbsag start the decline towards very low levels like 100iu/ml
tenofovir cannot help in this, so i would not use it
be sure to have good levels of vitd like 60-80ng/ml before starting peg, i believe it can help a little in lowering inflammation, it also boost peg repsonse because it activates genes involved with intf pathways (a research a read recently).sides should be much less, many report less sides on peg with low hbsag, usual sides at start but less when hbsag start the decline towards very low levels like 100iu/ml
the problem of using tdf when hbsag is so low:
you have immune activity since you have low hbsag and declining, but also some hbvdna which suppresses your own intf pathways but at the same time these virions boost your immune activity.if you go for tdf now you may lose some of this immune activity and need to stay on tdf for a few years to be sure peg add on will work
it can also happen that hbsag increase at first with the decline of immune activity, i think it is best to retry peg
you have immune activity since you have low hbsag and declining, but also some hbvdna which suppresses your own intf pathways but at the same time these virions boost your immune activity.if you go for tdf now you may lose some of this immune activity and need to stay on tdf for a few years to be sure peg add on will work
it can also happen that hbsag increase at first with the decline of immune activity, i think it is best to retry peg
Thank You Steff2011. My doctor is well know here in Albania. During the the first treatment my doctor follow only HBV-DNA, which was negative during the treatment. One month after the end of treatment my HBV-DNA was 240 IU/ml. My doctor order me to test HBV-DNA, and HBSAG after 6 month off the treatment. 6 months later my HBV-DNA was 1.4x10^4 IU/ml and Hbsag 1080IU/ml. My doctor was happy about Hbsag and order me to test only Hbsag (not HBV-DNA, it is not necessary he told me) 1.5 years after the end of treatment. 1.5 years after the end of treatment my Hbsag was 960 IU/ml. My doctor was happy and told me that Hbasg is decling. I ask him about HBV-DNA, he told me that Hbsag is decling so and HBV-DNA is declining and order me to test Hbsag. HBV-DNA and fibroscan (he don't want biopsy) after 2.5 years after the end of treatment. 2.5 years after the end of treatment my result are:
Alt 41 IU, Ast 30 IU Hbasg 747 IU/ml, Hbv-dna 4.0x10^4 IU/ml, Fibroscan (7.5 kpa) F2.
I was reading all the time your post Steff so I made a decision to go again for interferon.(in Albania we can not use tenofovir +interferon, beacuase is poor country, so I choose interferon)
Thank You Steff, god bless You.
Alt 41 IU, Ast 30 IU Hbasg 747 IU/ml, Hbv-dna 4.0x10^4 IU/ml, Fibroscan (7.5 kpa) F2.
I was reading all the time your post Steff so I made a decision to go again for interferon.(in Albania we can not use tenofovir +interferon, beacuase is poor country, so I choose interferon)
Thank You Steff, god bless You.
I am Elis! Thank You Steff! Thanks to you I proposed my doctor retreatment with interferon. I know that Italian doctors are the best. I have been in Roma and the doctor told me that even you will not clear your hbv at least you will wash up your body with interferon. Gracie mile!
you are welcome, look at otan post last year, in her case peginterferon plus simvastatin was used and hbsag was cleared before 24weeks
i think she started with hbsag around 400iu/ml and simvastatin may have done the trick of faster clearance (there are in vitro studies on sim but human trials never started, sim is too cheap...)
otan said sim increased sides, she used low dose 10 to 20mg at the start, then stopped but hbsag decline was started already
i think she started with hbsag around 400iu/ml and simvastatin may have done the trick of faster clearance (there are in vitro studies on sim but human trials never started, sim is too cheap...)
otan said sim increased sides, she used low dose 10 to 20mg at the start, then stopped but hbsag decline was started already
Hello Steff ! My cholesterol is high around 215 IU/ ml. Do you think I have to use Sim like otan did? I have a lot of pain in my right side near the liver, because of gas in colon(doctor told me after fibroscan that saw gas). To ringrazzio!
I have reada lot of your postes here helping successful clearing hbv. I wish and believe that you also will clear hbv, thanks to you rs doctors and Italian mediacal system that are so human with patients. My doctor has been specialize in milano for professor degree. I will post my whole treatment
antiviral effect is not exactly connected with cholesterol
anyway yours is a bit high so prescription should not be too much of a problem.sim has also anti liver cancer effect, so it is good to use unless it makes bad sides like too much muscles pains
anyway yours is a bit high so prescription should not be too much of a problem.sim has also anti liver cancer effect, so it is good to use unless it makes bad sides like too much muscles pains
hope fascist europe will be stopped before they make too much damage, we have indeed one the best world healthcare systems for free
they are trying to destroy public health care system as well as welfare in many european countries
they are trying to destroy public health care system as well as welfare in many european countries
I know Italian system is more human than even switrzeland. I have been in Italy a lot of time, even in viterbo there were a lot of pleasant doctors. I am happy that I live so close to italy. We in Albania can get a lot from Italian experience
Hello Steff! I would like to ask You that during treatment with interferon is the fibrosis of the liver reversible, i mean that F2 can go down for example F1,or even F0? Thank You
yes it does especially if hbvdna goes und and alt less than 30.but for this result pegintf needs to lower hbsag to very very low
you also need a healthy diet, not overweight and no fatty liver.anyway f2 is little fibrosis, most population is f1-f2 due to chemicals in processed foods and being fat...
you also need a healthy diet, not overweight and no fatty liver.anyway f2 is little fibrosis, most population is f1-f2 due to chemicals in processed foods and being fat...
PEG is once weekly, roferon is 3 times a week. A big difference in lifestyle.
The only bad thing about IFN treatment is the inconvenience of keeping the med in fridge and constant monitoring on blood count such as WBC and Neutrophils. I am sure you been through Roferon and know what's it's like.
Hopefully you don't get too depress because PEG IFN is not for people with already depressive mood as it can cause more problems. Good luck.
The only bad thing about IFN treatment is the inconvenience of keeping the med in fridge and constant monitoring on blood count such as WBC and Neutrophils. I am sure you been through Roferon and know what's it's like.
Hopefully you don't get too depress because PEG IFN is not for people with already depressive mood as it can cause more problems. Good luck.
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