risk of infectivity

[satimis]

Hi folks,

The hepatitis B virus is 50 to 100 times more infectious than HIV which has been accepted in medical field.  When chronic HBV patients with blood test proved to be, Hbsag -ve and Hbsab +ve and without occult HBV they can be regarded as healthy chronic HBV carriers.  They are NOT infectious to others as said in some medical journals.  

Is there any way to prove they won't pass on the virus to others?.  Is there any way to detect virus infection, not until the blood test result coming out?  Is there any method to assess the risk of infectivity especially to family members?


I found following articles

1)
Prevalence of hepatitis B infection within family contacts of chronic liver disease patients--does HBeAg positivity really matter?
http://www.ncbi.nlm.nih.gov/pubmed/12583467

2)
Natural history of chronic hepatitis B virus infection: An immunopathological study
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.1997.tb00503.x/abstract?systemMessage=Due+to+scheduled+maintenance+access+to+the+Wiley+Online+Library+may+be+disrupted+as+follows%3A+Saturday%2C+30+October+-+New+York+0500+EDT+to+0700+EDT%3B+London+1000+BST+to+1200+BST%3B+Singapore+1700+SGT+to+1900+SGT

relating to infection.

satimis

[satimis]

My point is :- a chronic HBV patient after taking Entecavir treatment or combo therapy for a period his/her blood may show Hbsag -ve, Hbsab +ve, pcr -ve, hbvdna at very low level almost undetected.  His/her doctor may stop the therapy with follow-up consultation arranged at 3/6 month interval.  In that period no blood test will be performed.  However there is no sign showing cccDNA becoming active again until next blood test which is arranged about one week before the follow-up consultation.  In that circumstance it keeps his/her family in tension.  Unless there is a precautionary way to monitor cccDNA at home.  There is no litmus paper testing HBV on his/her body fluid?

[stef2011]

they can be regarded as healthy chronic HBV carriers.
no they are healthy individuals otherwise you should count cronic carriers of hundreds of virus

Is there any way to prove they won't pass on the virus to others?.
the template of the virus is in some cells of the virus not the virus itself and it is very difficult to find virus in the blood and ehough blood to infect others, so the only way of infection is a transplant of organ or blood donation and even in these cases there may be transmission or not but for extra security blood is not accepted while organs can be accepted, in particular liver transplant of a seroconverted donor can transfer immunity to the receiver

risk of infectivity especially to family members?
none, no risk at all, no need of vaccine as well if hbsag negative

also condier than hbvdna und in a cronic hbv carrier makes very rare transmission in the couples, when hbvdna is und even sex is not a good way for infection