comment needed for f3 hbv (hbeag became negative) patient please

[halt651]

Dear All,

My mum was diagnosed cirrhosis. 6 months ago I posted a question about it thanks to stef2011 I had some advises. her situation is changed.
http://www.medhelp.org/posts/Hepatitis-B/cirrhosis-diag---help-and-advice-needed-for-reading-results-/show/2047474#post_9686062

Below is the story. I am worrying about the strategy that her doctor following at the moment.
I need your advises. She was using entecavir 0.5.
After 6 month with entecavir 0.5, her hbeag became negative and her doctor
Increased entecavir to 1mg instead of combining with tenofovir.

I appreciate a lot, please if you can have a look and answer my questions in regard to her results.

1/ do you think increasing entecavir to 1mg is a good idea? (what should we expect? Or how can we understand increasing to 1mg works?)

2/ what exactly means that hbeag became (-)? Is virus mutated and hbvdna is not representing number of virus anymore?

3/ hbvdna seems going down but not still undetectable is it a bad sign?

4/ since she is f3 and not f4, would interferon be useful for her? Or let me ask if q hbsag is lower than 1000 would she still be able start interferon?
(I know I need info of q hbsag and genotype but in turkey they do not check :(  that I am now trying to find a lab to know)

5/ any advices ?

historical info;

4th november 2013 ====> started entekavir 0.5
hbv-dna=1020000 IU/ml
alt 40 U/L (ref 33)
ast 51 U/L (ref 32)
hbeag +

27th november 2013
hbv-dna=16400 IU/ml
alt 22 U/L (ref 33)
ast 25 U/L (ref 32)
hbeag +

17 december 2013
Fibroscan median 10.5 kpa (206 db/m  ====> F3 diagnosed!!!!)

27 february 2014
Hbv-dna = 696 iu/ml
Alt 26
Ast 21
hbeag +

04 april 2014
Alt 19
Ast 24
hbeag  grey zone
Antihbe grey zone

30april 2014  =====> entecavir incremented to 1 mg :(
Hbv-dna = 696 iu/ml
Alt 26
Ast 21
hbeag (-) ===> became negative
Hbeab (+)

P.s: she did not start vitd3 and gmcaf yet, she lives in Mediterranean region of turkey there are a lot of sun + she follows diet (berry fruit etc) ; fresh vegy, fruits etc, walking 2 times a day.

Thanks in advance!
halit

[mer971]

Don't worry, less virus better for liver. Fortunately the liver is the only human organ that regenerates itself.

[melcul]

from my understanding, the imune system kills the infected cells, so when the hbsag and hbvdna goes down, the liver cells are under attack and the fibrosis is rising

[halt651]

I am just curious how come her Hbsag level and hbvdna level decrease but fibrosis increase?

[stef2011]

Everything is ok, for heptech just send them an email for help on how ordering

i hope you see same fast results as me and fibroscan starts lowering at next check by 6 mknths

[halt651]

btw, i thought my mum was using viread but i see that it is zentovir  
it is also tenofovir. I hope there is no difference :(

[halt651]

the latest hbvdan is 20iu/ml
the latest alt -> in july it was 19. (I will check again)


I ordered two box of each

Liposomal Curcumin Cu (II)
Liposomal Resveratrol
Liposomal Glutathione
Liposomal Vitamin C

I sent an email to heptech apparently I cannot buy directly from web.
Can you guide me how to buy from belgium?

I also sent an email to gcmaf.eu, before ordering I sent them an email with the results I had.

I checked fish oil from amazon especially from nordic naturals the max dha and epa I was able to find is;
https://www.nordicnaturals.com/uk/uk_nl_Arctic_CLO_Liq.php

I ordered 2 bottle.

I hope it is OK?