hbv and alinia=very very good news

[stef2011]

good article about first hbv patients trying alinia over one year in mono tx and 1 patient in combo with adefovir

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670405/

mono-tx with the highest hbe and hbsag loss, no resistance, no sides.i think we should start to use it very soon in combo with antivirals since it looks the best medicine for hbv by far.
at the moment we don't have a tx with no sides and no resistance which leads to hbsag loss in a very high percentage and according to this article it is synergistic with nucs and interferon

alinia is already on the market FDA-approved treatment for Cryptosporidium

[stef2011]

according to first clinical cases it takes about 1-2 years to clear on monotherapy on a high rate, combo with antiviral will give higher rates

researchers suggested use of entecavir or tenofovir which are more potent than sebvivo (telbivudine), also consider that a positive hbvdna on telbivudine for more than 6 months is very dangerous for resistance mutations.
the good part of sebvivo is that it has effect on hbsag too, what is your condition hbe pos or negative?

i cannot sugest alinia combo with telbivudine because there has been no vitro research about sinergy, if you don't see hbsag lowering in 6-12 months with hbvdna complitely und i would switch to tenofovir combo with alinia, a high hsag baseline is a good condition for hbe positive tenofovir therapy on genotypes A and D

[anjan8808]

Hello All
Below is my HBSAG reading i am using Sebivo right now and as per my doctor he will tell me on June whether I can stop taking sebivo or not.  
My latest(Jan-2010) HBV DNA value <3IU/ml.  SGPT 72.  

Is alinia is useful for me to make HBSAG -ve?
Thank you

(April-2010 Report)
HEPATITIS B SURFACE ANTIGEN REACTIVE NON REACTIVE
H 1375 Ref. ranges for
Electrochemiluminescence
or = 1.00 (Reactive)

[bram44]

Nice information !!

You are doing good job on this forum, as some old timers are taking it is easy :)

[bberry]

pump

[April63]

Thank you,Stefano.
If you hear anything else about it,please keep us posted.:)
Take care-April

[stef2011]

the website is not updated and hbv trial is the same from 2006

trials are very slow because romarke is not a big pharma company (see HR post, plus i don't think they have a lot of profit on alinia).
they are now making a different tablet with slow release and higher dosage for hcv and hbv, i think they want to make the trial of this new tablet after they have tried it on hcv

the dosage until now has been 500mg twice daily (1000mg), new release tablet is about 1350mg twice daily, the new tablet is also focused on antiviral potency rather than antibacterial potency.
i don't think they produce for the whole world but give licence for other companies, for example hcv tablet will be produced by another company in japan.

i also think there might be a lot of off label treatments around the world like it happened for tenofovir, FDA approved it on 2009 but many has used it since early 2002/2004, for alinia it can be even more because it has no sides