hcc at mid-30s

[rosy888]

Hi everyone, I am new to this forum and glad to find many useful discussion here.
I am in my mid-30s and recently just had a liver resection due to hcc. Good thing is it's caugh in early stage...

Brief history:
-got hepB probably at birth
-ALT elevated for a few years in my 20s (in the 50~100 range; not treated that time due to no effective drug available and want to have baby first)
-ALT got back to normal in the past few years, together with lower virus DNA (decreased from 10^7 to <2000 copy); also eAg became netagive while eAb became positive)
-normal ultrasound findings (monitor every 6 month) in the past few years

However, a few months ago, a tumor was found caugh by AFP and comfirmed by MRI. Have been on Baraclude since then (never got treated before).

My questions are:
1. why hcc was found suddently although test results seem to suggest everything was getting better in the past few years(normal ALT, low virus load, e-seroconversion) ?
2. is  Baraclude the best option for me?
3. any other things I should consider/try to prevent re-occurance?

Any comment/suggestion would be highly appreciated!

[stef2011]

What do you mean "liver must be cleared on fat"? I don't have fatty liver though...thanks

good you dont have fatty liver but add simvastatin to your treatment, it has 505 reducton on hcc risk, the highest hcc risk reduction

Yes will try to find ways to have hbsAg quantity tested. When you said "etv+intf combo", do you refer to sequential combo (etv first, then intf add-on at later time)?

you can try both sequential or combo directly, the point is getting rid of hbsag or lower it.i posted a study time ago where reduction of hbsag was even followed by hcc size reduction

[rosy888]

Thanks stef for your input.  A few questions below:

"as to hbsag quantity:
less than 1000iu/ml very low hcc risk equal to those who cleared hbv
more than 1000iu/ml higher risk
so i d definitely check this and try to keep it less than 1000iu/ml by combo etv+intf or tdf+intf.intf should have also an effect on immune system against hcc but i am not expert on intf during hcc or after resection so you have to check with very expert liver specialsts.sinc eintf is also a drug for many cancer is should be helpful"

Yes will try to find ways to have hbsAg quantity tested. When you said "etv+intf combo", do you refer to sequential combo (etv first, then intf add-on at later time)?

"also fibroscan is very important, not biopsy, fibroscan monitoring with values less than 7-8kpa are at decreased risk of hcc while those with values higher at increased risk"

Again, never have fibroscan done due to not available in the US.

What do you mean "liver must be cleared on fat"? I don't have fatty liver though...thanks

[rosy888]

"mine was never as high as 200 it was in the 30,s before but is now at 5.8 i checked 3 months ago.i will keep a close eye on it. take care of yourself. good luck ."

If it goes back to normal, rather than keep increasing, should be fine. Always good to be cautious though. Good luck to you too.

[rosy888]

Thank you so much for the info on where to find a lab that does HBs Ag quantification!  Yes will provide update if find something that works.

[stef2011]

as to hbsag quantity:
less than 1000iu/ml very low hcc risk equal to those who cleared hbv
more than 1000iu/ml higher risk

so i d definitely check this and try to keep it less than 1000iu/ml by combo etv+intf or tdf+intf.intf should have also an effect on immune system against hcc but i am not expert on intf during hcc or after resection so you have to check with very expert liver specialsts.sinc eintf is also a drug for many cancer is should be helpful

also fibroscan is very important, not biopsy, fibroscan monitoring with values less than 7-8kpa are at decreased risk of hcc while those with values higher at increased risk

liver must be cleared on fat, fatty liver is another hcc risk promoter

[Flameboy]

mine was never as high as 200 it was in the 30,s before but is now at 5.8 i checked 3 months ago.i will keep a close eye on it. take care of yourself. good luck