my doctor's prescribed my brother Sebivo telbivudine we need your advice help us pls

[Sevara]

Hi everyone !
My brother facing hepatit B and our doctor prescribed him Sebivo Telbivudine Tablets. We live in Uzbekistan, Tashkent. In our country this tablets are not available. This tablets are produced in USA. I have one friend who lives in USA i asked her to get this medicine and  send it me  to Uzbekistan. But she said that in Us in order to get any medicine they need prescription from doctor. We have prescription but we don't know is it will be effective in us or not.
Pls help !!!

[Sevara]

thank u a  lot !!!

[imdb90]

Sebivo> risk of peripheral neuropathy and myopathy wich are debilitating diseases.

[stef2011]

those tests are useless to define both hbv status and liver damage

for liver damage you can monitor only with fibroscan or take biopsy every 5 years

to define hbv status: hbsag quant in iu/ml, hbeag/hbeab, ast/alt and to all these tests/fibroscan you add hbvdna

[Sevara]

Can you give me any suggestions conserning this info above . Thank u

[Sevara]

Thank you very much for your advices!!!!

Here i have more detailed info about his analysis

Firts time when he was taking his test was on 27/02/2012, his analysis on
Polymerase Chain Reaction was - POSITIVE
( result 1.7E+04копий* НВV-Ml) in english i guess it is like that (1.7E+04copy*NBV-Ml )
however some days past on 2/03/2012 he took one more test on ИСA ( i dont know how to translate this test ИСА is in russian) HG antigen was - NEGATIVE. We was surprised how come ...

[stef2011]

definitely right, 19yo is no age for antivirals unless close to cirrhosis but it is very very very rare most are immune tollerant at this age

double check with another doctor, that might be not reliable or updated on hbv

[calmama]

"By the way he is 19 years old :( "

He may still be in immune tolerance phase and no treatment is needed in this phase.  Was he checked for alt, ast, and liver damage (Fibroscan or liver biopsy)?

Do not rush into an antiviral when he is only 19.  Antivirals often times have to be taken for a very long time and can not be stopped carelessly.

[stef2011]

http://doublecheckmd.com/EffectsDetail.do?dname=Tyzeka&sid=89245&eid=9162

[stef2011]

http://www.springerlink.com/content/31j07q870177j21h/

Telbivudine myopathy in a patient with chronic hepatitis B, more than one patient dyed reported in china

http://depts.washington.edu/hepstudy/images/hepB/HBV_Choice_d07.png

telbivudine 17% resistane at 4 years already without hbv clearance vs tenfovir 0%

[stef2011]

it is not what i think, it is the only one that makes no hbv mutations/resistance, all the other have, so little place to choose

until today interferon and tenofovir have no hbv resistance, so the most potent and safe

hbv cures not yet on market: rep9ac replicor, gs9620 gilead, myrcludex

[Sevara]

You think that Tenofovir (viread) is the most effective one ?  It is better than Sebivo ?

[stef2011]

sebvivo is not a firstline hbv drug because it makes resistance and it doesnt clear hbv.the most potent and safest drug on hbv is tenofovir (viread) it is cheap and it doens t have resistance
generics are very cheap, tenvi cipla, tavin emcure and so on but these antivirals dont clear hbv they just block liver damage so you have to check first if there is liver damage by fibroscan

[Sevara]

By the way he is 19 years old :(