What are your ALT, AST, HBeAg, HBeAB, HBcAB, HBV DNA?
my HBeAg is (R1_>1.000) .22 nonreactive, HBeAB (R1_1.000) .27 reactive, ALT is 18 U/L, my HBV DNA is 48,370 IU/ML ( 281,513 copies/ml). These results were taken last march 8, 2008. So i took the HBsAg with titer eclia only last sept and just recently december.
i really do hope if someone is gonna interpret it well.
According to the 2007 guideline:
HBeAg-negative, anti-HBe Positive Patients with Normal ALT Levels and HBV DNA <2,000IU/ml (Inactive HBsAg Carriers). These patients should be monitored with ALT determination every 3 months during the first year to verify that they are truly in the “inactive carrier state” and then every 6-12 months.
You belong to the above category with the exception that your HBV DNA is higher than 2000IU/ml. Some doctors may suggest antiviral treatment while others may suggest liver biopsy before making that decision.
When you are e-antigen negative with an elevated viral load it is possible that the virus has mutated and you could benefit from anti-viral therapy. Please read the Hep B Welcome page at this website.
If my virus mutated, does this mean that i can be cured?
No, it doesn't. There is no cure at this time.
I just visited my gastroenterologist and she said i should take zeffix lamivudine 100mg tablet for 2 years. She said if my body reacts well with the medicine then the viral load will lessen. If it doesn't then the virus would mutate so i should take another treatment.
I forgot to ask this question to my gastro. Is lamivudine a trigger for mutation if your body doesnt react well with the treatment? she said if will increase the viral load if my body cant react well. Is it better not to treat hepa b with lamivudine since i dont feel anything at all and exposing my liver with this drug could somehow improve or lessen the viral load?
If you choose treatment, lamivudine is not the best choice.
so what can you suggest? should i not treat this with lamivudine? Or will i just leave it be considering that i don't feel anything at all?
Entecavir is more potent with less resistance headache.
what can you say about my treatment?
Lamivudine is no longer recommended as a first line monotherapy.
But, if it is your ONLY choice then I guess start treating while your viral load is low? LAM has a bad resistance profile. Cajim has good information.
What's your ethnic background? Age? Gender?
If you are eAntigen Non Reactive and eAntibidy Reactive with a high viral load, you may need a lifetime of treatment. So resistance will be a concern. If your doctor wants to treat with LAM only until resistance to LAM is detected, it's a bad plan.
Given your viral load is NOT THAT high yet. The minimum I would ask for is combo with LAM and Adefovir. You will improve your resistance profile a great deal. As Zelly pointed out just LAM treatment is no longer recommended. If you could get Entecavir and / or Tenofovir, it's even better. It's likely you have to think long term.
Now, I'm no doctor, but I would discuss the above with your doctor.
Well, I am a filipino and i am 28 years old.
Are you sure your:
HBeAg is nonreactive
HBeAB reactive
I would retest this. Because you are a little young to go through this conversion process at 28. It could be that HBeAg and HBeAB are flip flopping if you are in the middle of this conversion process.
If it's correct than, the virus escape the eSeroconversion process by mutating. If this is the case, then you would likely need a lifetime of treatment and doing it with LAM alone is not a good idea. You may need decades of treatment so you need long term planning for the resistance issue.
Its possible Steven. By the time I was diagnosed at 27/28 I was eAg- and eAb+. A lot of genotype Bs undergo earlier seroconversion.
Is hepa b a ground for unemployment in singapore? I mean is hepa b one of the constraints in applying for a job in singapore? I really appreciate if someone would answer this one. someone who is knowledgeable enough about governemtn regulations in singapore with regards to hepa b in relation to employment.
Zelly: Okay, okay, it's possible....sheesh. Seriously, it is important ot keep in mind that there are no absolute numbers in HepB. That's why each has to learn their own unique presentations to make sound decisions.
Michaelyuri: I have no idea on Singapore. Don't we have another forum member from Singapore?
hello! i just had hepatitis b antibody (anti-HBS) quantitative test and the result is reactive (121.8 mIU/mL).. What does it mean? I hope someone will help about this..
you have got hbv sometime during your life and now you are immune or you got vaccine at birth/very young
What HBsAg Quantitative (Technique ECLIA Quantitative) Positive 329 IU/ml (N:<0.05 IU/ml) means? Is it the same technique as Abbot Architect?
yes if result is iu/ml, you just have to see iu/ml after the number
this hbsag quantity 329 IU/ml is extremely low and clearing infection, is it decreasing fast or stable?if decreasing low it is good to add interferon to current therapy so that clearance is faster
Four months ago it was 1,600 IU/ml but on Abbot Architect. This time it is ECLIA technique. I don't know the difference between these two technique. You said if HBsAg quantitative <1,000 IU/ml, then the antibody is surging? At what level can we stop medication?