iNTERFERON

[Mars86]

what is the possibility and for how musv=c time does it take to clear HbsAg using interferon (if possible) ?
HBsAg Quant. 89,000 iu/ml

[Mars86]

thanks

[stef2011]

interferon+tenofovir is the best option today, mono vs combo below:

peginterferon: hbsag clearance at 1 year about 7-10% which increases to about 30% at 5-10years after intf is finished (intf effect remains after finished for years)

tenofovir: 16% hbsag clearance at 3 years

peginterferon+tenofovir: 24% hbsag clearance at 1 year

sequential combination:
3 years of tenofovir and then interferon add on for 2 years:
hbsag clearance about 40% first year, 50% hbsag decrease to very low levels around 10-300iu/ml which ususally clear hbv even with no drugs slowly with time, 10% no hbsag decrease

we dont have the data on tdf+intf add on on the second year but with such low hbsag 10-300iu/ml hbv clearance is just a question of time