need help in interpreting my liver test

[seas123]

Good day!

I am new in here. I just need help in my SGPT/ALT, hepatitis profile  w/ HCV, ultrasound of the liver, HBV-DNA results.

SGPT/ ALT

07-08-09  is   10  normal is 4~41
12- 04 -10 is 21 normal is 4 ~41

Hepatitis Profile w/ HCV:

HBsAg w/ Titer  (ECLIA) = 2473.000 cut-off value is 1.000 REACTIVE

Anti HBs (ECLIA) = < 2.00 IU/L  cut off value is 10.000 NON REACTIVE

HBeAg (ECLIA) = 0.194 cut off value is 1.000 NON REACTIVE

Anti HBe ( ECLIA)  = 0.943 cut off value is 1.000 GRAY ZONE
result obtained is in the gray zone  (indeterminate) area. Suggest follow-up testing if clinically indicated

Anti - HAV IgM (ECLIA) = 0.316 cut off value is 1.000 NON REACTIVE
Anti - HBc IgG (ECLIA) = 0.007 cut off value is 1.000 REACTIVE
Anti HCV (ECLIA) = 0.022 CUT OFF VALUE IS 1.000 NON REACTIVE

note: AHBcIgG, AHBe result/s below the cut off value is / are considered REACTIVE ( why is this so?)

UTZ of the liver

REPORTS:

Liver Span: 12.6 cm

The liver is within normal limits in size. Configuration and lobar proportion are within physiologic range. Parenchymal echogenicity is mild to moderately increased. Parenchymal echotexture  is homogenous. A tiny, 1.0 cm mildly echopenic focus is seen in the anterior inferior segment of the right lobe presenting with smooth outline and no discernable through transmission. The hepatic veins are of normal course and calliber.

IMPRESSION:

Normal sized liver with mild to moderate degree of diffuse fatty change.
Non specific focal lexion, anterior inferior segment, right lobe as described, which could represent a high density cystic lesion or a low density nodule. Suggest correlation with other clinical parameters.

HBV - DNA

TARGET NOT DETECTED

Thanks in advance for helping me. I am planning to migrate to another country but a scared that they will decline my visa application because of my condition.

[stef2011]

you must treat it for liver disease by healthy life style/vit E

if hbe negative you might try nitazoxanide treatment to get rid of hbsag, now that virus has such low replication it is weaker and it is the right time for drugs with no sides like ntz

if you start ntz check if you can also monitor hbsag quantity by abbott architect

[seas123]

Hi! got my new HBV DNA results today it is still < 6 IU/ml like last year. So what does this indicate? with all my blood test within normal range but with  a non specific focal lesion and a mild to moderate diffuse fatty change?

[seas123]

Ok thank you very much. I will also seek the advice of my Dr. I will ask her about the golgi protein test and the bcp and precore mutants as well.

[stef2011]

afp is normal so probability is it is not HCC, if you want to be sure 100% check if golgi protein test is available in your country or just follow the lesion by ultrasound if it doesn t grow fast in 4 months it is not HCC or it is benign

also check bcp and precore mutants because they promotes liver cancer and genotype (B and C are very dangerous for liver cancer)

for example i have the mutants but genotype D and in my case hbvdna must be und always

[seas123]

Got my AFP results just now.
AFP = 1.43 IU/ml  reference range is < 11.30 so does this mean that my AFP is normal? so if yes, does this mean that the 1.0 cm cystic lesion or nodules is not cancerous in nature?
Thank you very much.

[seas123]

Hi! regarding my UTZ results I haven't brought it to my doctor yet because my next appointment will be after I get my new HBV DNA results which will be next week. That's why I still don't know what the doctor will say about the possible cystic lesion or nodules. my HBV DNA count last year was less than 6 IU/ ML (less than 35 copies / ML) that's why the result was HBV DNA target not detected.

[stef2011]

at the moment you are inactive, this means nothing because hbv fluctuates between inactive/active but virus is now weak so treatment with immune modulator would be good before bcp/precore mutant appears
i was like your situation until 18-19yo, then i moved to hbe negative/hbeab positive and then to cirrhosis at 40yo

note: AHBcIgG, AHBe result/s below the cut off value is / are considered REACTIVE ( why is this so?)
it doesn t matter, it is just the reagent test which is positive for low values and negative for high values, it is the opposite compared to other tests but it doean t matter to us we just care about positive/negative

A tiny, 1.0 cm mildly echopenic focus
this can be good or very bad, did they check what it is?these focuses can be nothing or can be liver cancer.do not be scare you have probabbly nothing but do check for what this is because 1cm is not small a liver cancer cannot be treated once 3-5cm big
melatonin has antioxidants and anticancer properties, its action mybe useless or useful on prevention of liver cancer, we don t know, it is good to take anyway since it doesn t make any damage
antidiabetes drugs thiazolidines have anti liver cancer properties and might be used for liver cancer prevention

as to your hbv situation you should check the quantity of hbsag to know if you are clearing or might be able to clear hbv.quantification is possible with abbottt architect and result unit is iu/ml, a value lower than 1000-2000iu/ml can be eradicated by interferon+nitazoxanide or by nitazoxanide (alinia) monotherapy

this test is not in iu/ml and value is not hbsag quantity HBsAg w/ Titer  (ECLIA) = 2473.00