SGPT & SGOT (results)

[che79]

Can somebody help me with my blood test result?
     Test                       Ref. Value          Method
SGPT = 33.3 U/L    F: Up to 33 U/L    COBAS C111
SGOT = 29.2 U/L    F: Up to 32 U/L    COBAS C111

Thanks

[cajim]

Sounds like you are in immune tolerant stage.

2007 guideline:

Among individuals with perinatally acquired HBV infection, a large percent of HBeAg-positive patients have high serum HBV DNA but normal ALT levels.  These patients are considered to be in the “immune tolerant” phase. Many of these patients develop HBeAg-positive chronic hepatitis B with elevated ALT levels in later life.  In sub-Saharan Africa, Alaska, and Mediterranean countries, transmission of HBV usually occurs from person to person during childhood.  In these populations most children who are HBeAg positive have elevated ALT levels and seroconversion to anti-HBe is common near or shortly after the onset of puberty. In developed countries, HBV infection is usually acquired during adulthood through sexual transmission and injecting drug use.  Very little longitudinal data are available, but liver disease is generally present in persons with high HBV DNA levels.

Among carriers with elevated ALT levels, the rate of clearance of HBeAg averages between 8% and 12% per year but is much lower in carriers who are in the immune tolerant phase (mostly Asian children and young adults with normal ALT levels) and in immunocompromised subjects.  HBeAg clearance may follow an exacerbation of hepatitis, manifested by an elevation of ALT levels.  Older age, higher ALT, and HBV genotype B (vs. C) are associated with higher rates of spontaneous HBeAg clearance.

...

HBeAg-Positive Patients with High Serum HBV DNA but Normal ALT Levels. These patients should be monitored at 3 to 6 month intervals.  More frequent monitoring should be performed when ALT levels become elevated.  Patients who remain HBeAg positive with HBV DNA levels greater than 20,000 IU/ml after a 3 to 6 month period of elevated ALT levels greater than two times the upper limit of normal should be considered for liver biopsy and antiviral treatment.  Liver biopsy and treatment should also be considered in patients with persistent borderline normal or slightly elevated ALT levels particularly if the patient is above the age of 40. Liver biopsy is usually not necessary in young patients (below 30) who are HBeAg-positive and have persistently normal ALT.

[che79]

Thanks zellyf!

I'm 29 years old, female, Here's my previous blood test result:
                                                 Normal Value
HBsAg w/ titer = 211.800                 COV - 1.0
Anti-HBS = <2.00                            COV - 1.0
HBeAg = 628.600 Reactive               COV - 1.0
Anti-HBe = 5.85 Non Reactive           COV - 1.0
Anti-HBe Igm = 0.361 Non Reactive   COV - 1.0
Anti-HAV Igm = 0.307 Non Reactive  COV - 1.0
SGPT = 48.00                                 9 - 53

[zellyf]

I should add that ALT treatment guidelines are taken into consideration along with viral load, e-antigen status, age, family history, length of infection and state of the liver.  Of these viral load tends to be considered the more significant factor.  Do you know your viral load and e-antigen status?

[zellyf]

SGPT is also known as ALT and its the more important of these two.  Looks like you are just above the lab upper limit of normal (ULN).  Lab normal is not always true normal.  Tell me your age and gender again.  In general, a healthy ULN for a man is 30 and its 19 for a woman.  Treatment guidelines sometimes use 2xULN for a sustained time.  

One ALT is just a snapshot.  You'll need a series of these to get a better idea of your situation.  For now, this looks pretty good.  

Remember, lots of things can elevate ALT.  NSAIDS (Advil etc), Tylenol, alcohol, fatty foods, excessive exercise.