Could microglia eradication provide relieve for this hell?

[lookbehindyou]

There's this new drug currently in phase 1b or 2
It's called plx3379

It destroys the IFN induced chronic activity of the microglia, by killing the microglia itself.

After a week of cessation of treatment the microglia grew newly and insensitive.

Couldn't that provide a solution to this HELL post IFN?

Ah, the stuff has side effects but they gave it to end stage tumor patients for about 250 days in doses of 1000mg / d

I suggest that some weeks taking this stuff could substantially improve brain functioning, by "resetting" the microglia

[Bruin1903]

Thank you very much for explanations.....hope that it is not too much
of an experiment and that you get a great result. Do you have a start date ?

[lookbehindyou]

and yes Bruin, IFN causes brain inflammation. Memory impairments, cognitive impairments, psychomotor degeneration, fatigue... that all comes from the inflamed brain. hang in, i will do this experiment and i will do it for everyone with this problem, regardless of the outcome.

[lookbehindyou]

i contacted Dr Green from the Green Lab who's writing about this method.
Yes, the language is hard and one has to research things to understand the logic.
thank god my father has a PhD in Chemistry and teached me about chemicals and basic pharmacology from a young age on.
I struggled with the markers, IBA1, GFAP, S100 and so on but it*s easy to understand. one hasn't to fully understand every detail, it's sufficient to realize that there is no collateral damage like with Diphteria Toxin, that would be too unselective. it is sufficient to realize that the agent does not kill other cells than microglia within the CNS. otherwise i would stay the hell away from this experiment. the inhibitor is highly selective, Interferon is just the complete opposite.

[Bruin1903]

I find the language of science hard to understand but these findings make
complete sense and can see that they will lead to more effective
medicines for a wide range of neurological complaints. My subjective experience is that interferon caused inflammation in my brain and from that
all the side effects flowed. Given this research this seems an accurate supposition.

[Frank J. Perrotta]

Good luck with your experiment

Best if you have your own MRI machine to examine the progress!

Here is the new findings I was looking for:

http://neurosciencenews.com/lymphatic-system-brain-neurobiology-2080/ = Researchers Find Missing Link Between the Brain and Immune System

[lookbehindyou]

i realized something today.

Imagine 'primed' microglia within the CNS. Activated by multiple factors.
The agent inhibits CSFR1 which leads to apoptosis (cell death) of microglia.

A complete wipeout isn't necessary. (and would maybe too toxic because of the daily amount needed)

Mice receiving 16-75mg/kg were depleted of microglia but in the same time, new repopulated.

Imagine the 'sick' microglia. If one is doing a regimen of maybe 1000mg/day for 3 or 4 months every unique microglia is replaced by a new one. It will kill all the sick microglia sooner or later. the amount of present microglia is not drastically reduced, it just replaces them bit by bit...