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PLEASEEEEEE ADVICE .
hello to all , and i hope my post finds u all in better health and spirit , could any of u pleaseeee advice or tell me if nicotine gum ( nicorette ) can elevate liver enzimes , my alt is 340 and ast 110 . i have been chewing the gum for over 6 months ( about 7-8 / 2mg gums ) a day , i do have hcv but have never had such high enzyimes for such a long period , i got infected 3 years ago .... i dont drink and am trying to quit smoking with the help of the gum .
i have also started shedding a LOT of hair , which is one of the side effects of the nicotine gum ...
I have tried to research if the nicotine gum can effect the liver in a bad manner ... but my search has not been succesfull and i just cant seem to pinpoint if it is the gum that could be doing this ....
i highly appreciate ure help
thanking u in advance
warm regards
pacman .
i have also started shedding a LOT of hair , which is one of the side effects of the nicotine gum ...
I have tried to research if the nicotine gum can effect the liver in a bad manner ... but my search has not been succesfull and i just cant seem to pinpoint if it is the gum that could be doing this ....
i highly appreciate ure help
thanking u in advance
warm regards
pacman .
Best Answer
Didn't you say a short time ago that it was resveratrol that caused a jump in your enzymes?
The reality is that sometimes enzymes go up for a clear reason-it can be a drug that you took, alcohol intake. It is also possible if you just finished your treatment and relapsed.
But sometimes LFTs just go up for no clear reason. It may happen just because your hepatitis becomes more aggressive, and the virus attacks your liver. My husband experienced similar raise in the enzymes last year. And this has nothing to do with viral load/replication. You can have huge viral load and normal LFTs. And you can have very low viral load and high AST/ALT.
The reality is that sometimes enzymes go up for a clear reason-it can be a drug that you took, alcohol intake. It is also possible if you just finished your treatment and relapsed.
But sometimes LFTs just go up for no clear reason. It may happen just because your hepatitis becomes more aggressive, and the virus attacks your liver. My husband experienced similar raise in the enzymes last year. And this has nothing to do with viral load/replication. You can have huge viral load and normal LFTs. And you can have very low viral load and high AST/ALT.
thank u for ure input , its really sweet of u both , i have stopped chewing the gum from today and am not smoking either ... will get blood work done again in 2 weeks .. hope its a bit low by then ......
thanking u again
wishing u both well
regards
pacman .
thanking u again
wishing u both well
regards
pacman .
Also the insert comes with this
Tell your doctor if you have:
• diabetes
• heart disease or have recently had a heart attack
• high blood pressure
• liver or kidney disease
• thyroid disease
• stomach problems or ulcers
Tell your doctor if you have:
• diabetes
• heart disease or have recently had a heart attack
• high blood pressure
• liver or kidney disease
• thyroid disease
• stomach problems or ulcers
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Pharmacokinetics
As nicotine enters the body, it is distributed quickly through the bloodstream and can cross the blood-brain barrier. On average it takes about seven seconds for the substance to reach the brain when inhaled.[citation needed] The half life of nicotine in the body is around two hours.[11]
The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco, dipping tobacco, snus and snuff, which are held in the mouth between the lip and gum, or taken in the nose, the amount released into the body tends to be much greater than smoked tobacco. Nicotine is metabolized in the liver by cytochrome P450 enzymes (mostly CYP2A6, and also by CYP2B6). A major metabolite is cotinine.
Other primary metabolites include nicotine N'-oxide, nornicotine, nicotine isomethonium ion, 2-hydroxynicotine and nicotine glucuronide.[12]
Glucuronidation and oxidative metabolism of nicotine to cotinine are both inhibited by menthol, an additive to mentholated cigarettes, thus increasing the half-life of nicotine in vivo.[13]