Aa
4 week lab results
Got lab results back. HCV RNA went up to 9380 from 293 two weeks ago. :( doc said to have more bloodwork done next Friday & call him 5 days later to see if we go forward or stop treatment.
I'm hugging pups. Hubby says to stop & realize that 9380 IS less than 1.5 mil where we were on July 15.
I'm hugging pups. Hubby says to stop & realize that 9380 IS less than 1.5 mil where we were on July 15.
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Correction: All three drugs should be stopped with viral load of 1000 IU/mL or above at weeks 4 or 12.
Sorry about your news, as lynda says tx should be stopped.
Stopping Rules
According to the telaprevir label, all 3 drugs should be discontinued if HCV RNA is ≥ 1000 IU/mL at treatment Weeks 4 or 12. This rule exists because it was shown in clinical trials that if HCV RNA levels did not drop < 1000 IU/mL at Week 4, the likelihood of achieving SVR was exceedingly low. Continuing telaprevir alone without adequate virologic suppression increases the likelihood for emergence of resistance variants. The label also specifies that if HCV RNA is detectable at Week 24, pegIFN/RBV should be discontinued.
Stopping Rules
According to the telaprevir label, all 3 drugs should be discontinued if HCV RNA is ≥ 1000 IU/mL at treatment Weeks 4 or 12. This rule exists because it was shown in clinical trials that if HCV RNA levels did not drop < 1000 IU/mL at Week 4, the likelihood of achieving SVR was exceedingly low. Continuing telaprevir alone without adequate virologic suppression increases the likelihood for emergence of resistance variants. The label also specifies that if HCV RNA is detectable at Week 24, pegIFN/RBV should be discontinued.
The above is from clinical care options site.
http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
doc said since my viral number was low the first time that he wanted to go a little more, that it was a gray area.
yes, i'm doing the triple therapy - sorry i didn't put that together with the letters PI - a little of this technical stuff goes a long way with me and it gets confusing. all i want to do is get well.
I certainly feel pretty FUTILE now for sure - futility rules or not - thanks hrsepwrguy and lynda607.
sorry if i seem slow.
yes, i'm doing the triple therapy - sorry i didn't put that together with the letters PI - a little of this technical stuff goes a long way with me and it gets confusing. all i want to do is get well.
I certainly feel pretty FUTILE now for sure - futility rules or not - thanks hrsepwrguy and lynda607.
sorry if i seem slow.
Futile Shmutile. I feel such a bond w/ you cuz we started on the same day. So I'm feelin mad right now. Let's wait n see... Go for the 2nd opinion if you have that option w/ ur insurance. For some reason they have you a week ahead of me on blood work. What was ur first set? when was it done? forgetful.... Must be the PI...
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