Aa
4 weeks VL results after Alinia from illo
Illo, by now you should be on Alnia for at least 4 weeks. It would be very important to know the early response rate from this new and possibly extremely interesting drug to treat HCV and HBV.You did not indicate if you take Alinia alone or in combo with one of the Peg Interferons. Also did you have a VL before entering treatment?
Wissen Sie, ob Romark klinische Studien zur Tripletherapie mit Alinia auch in Europa plant? Ich w
I was curious about a couple of comments you made in passing:
(1) regarding nitazoxanide's possible mode of anti-viral action as promoting misfolding of a viral potein . Which protein? Is additional information available regarding this ?
(2) "increase cancer risk anywhere near ribavirin". I've always been bothered by the fact that ribavirin, a presumed viral mutagen and a known teratogen, specifies in its drug spec sheet that mutagenic studies have never been completed. Does your comment indicate there might be good reason for this omission?
re nitazoxanide, I didn't find much in the <a href="http://www.fda.gov/medwatch/SAFETY/2005/Jun_PI/Alinia_PI.pdf">FDA drug sheet</a> to worry about. Though only approved in '04 I got the impression it had been used in a veterinary context for much longer.
(1) regarding nitazoxanide's possible mode of anti-viral action as promoting misfolding of a viral potein . Which protein? Is additional information available regarding this ?
(2) "increase cancer risk anywhere near ribavirin". I've always been bothered by the fact that ribavirin, a presumed viral mutagen and a known teratogen, specifies in its drug spec sheet that mutagenic studies have never been completed. Does your comment indicate there might be good reason for this omission?
re nitazoxanide, I didn't find much in the <a href="http://www.fda.gov/medwatch/SAFETY/2005/Jun_PI/Alinia_PI.pdf">FDA drug sheet</a> to worry about. Though only approved in '04 I got the impression it had been used in a veterinary context for much longer.
MEDICAL PROFESSIONAL
No further details about Nitazoxanide's "protein folding interaction" are available anywhere. My source is personal communication from one of the NONRomark researchers involved in the study and he did not give me data on which that currently speculative mechanism was based.
Cancer risk of riba - see above.
Cancer risk of riba - see above.
Hallo, it indeed seems to have a favorable tox profile and I would not hesitate to take nitazoxanide myself, if it was available here. This statement should give a feeling about my estimation. No CYP450 and so on, great. No P-glycoprotein drug interactions too, right?
I do not want to construct any wild speculations about sides or interactions, it lookes harmless.
My hesitation for any off-label combo under the management of patients themselves may be a little bit too anxious. If someone has only a hammer, the one always thinks the problem is a nail ;-) I am working in the field of marketing authorisation since 15 years, could be that I lost a pragmatic view for things like this.
Nevertheless I collect some off-label documentation in another indication here too. Physicians document the effect of individual methylphenidate therapy for some people with therapy refractory post-hepatitis fatigue. Some patiente have a much better quality of live since they take it. If these pioneer results are promissing, clinical studies phase III will follow. It is helpful if there is a very good documentation by a physician.
However, even if things seem to be very clear and simple, there may be bad surprises. To my knowledge the phase I researchers of TGN1412 in London did not make a single mistake, toxicity had been tested forward and backwards before, they just couldn
I do not want to construct any wild speculations about sides or interactions, it lookes harmless.
My hesitation for any off-label combo under the management of patients themselves may be a little bit too anxious. If someone has only a hammer, the one always thinks the problem is a nail ;-) I am working in the field of marketing authorisation since 15 years, could be that I lost a pragmatic view for things like this.
Nevertheless I collect some off-label documentation in another indication here too. Physicians document the effect of individual methylphenidate therapy for some people with therapy refractory post-hepatitis fatigue. Some patiente have a much better quality of live since they take it. If these pioneer results are promissing, clinical studies phase III will follow. It is helpful if there is a very good documentation by a physician.
However, even if things seem to be very clear and simple, there may be bad surprises. To my knowledge the phase I researchers of TGN1412 in London did not make a single mistake, toxicity had been tested forward and backwards before, they just couldn
Have an Answer?
You are reading content posted in the Hepatitis C Community
Learn about this treatable virus.
Getting tested for this viral infection.
3 key steps to getting on treatment.
4 steps to getting on therapy.
What you need to know about Hep C drugs.
How the drugs might affect you.
These tips may up your chances of a cure.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
