About log drop???

[Mister beagle bailey]

Good morning all,

I have been seeing a lot about log drops, Etc.  Could someone please explain this to me?  I have no idea what it means.

  Thanks,

  The Beagle

[NYgirl]

Hope you got it now....you had a three point drop on the hgb - log drop is explainned above perfectly.

I remember when I had no clue either what any of it meant and it's so simple but not until SOMEONE EXPLAINS IT IN ENGLISH!

You are coming along fabulously in the knowledge department - why it seems like you JUST started and look at all you know already!

GOOF - are you on week 18 or 19?  I am confused and can't remember what week I am on (think I just did 18) and I know you are one week before me.

[wMich]

Hello from sunny snowy Michigan,
Jumping the thread here BUT....I got some great news Friday when the nurse called to say my 24 week Heptimax came back "undetectable"! (>5IU/ml) I am male, 53, infected for 20-30 yrs, geno 1a, pre Tx VL was 1,140,000 IU/ml.

I do have questions about the second "half" of Tx and beyond: Is there a good reason to have another PCR at week 36? I know I will probably be having one at 48 weeks and again 24 weeks post-Tx. Also, is there any data (or general consensus) for type 1a people ultimately achieving SVR with 48 weeks of Tx when found undetectable at the 24 week point of Tx? I just started week 26 of 48. I welcome your feedback/observations.

For me the intensity of sides has wavered through the 25 weeks. Recent challenges include dry skin on my face which is often cracked and painful around the corners of my mouth and just outside my left eye. The skin to the sides of my nose is red and flaking sometimes as well. The body aches come on like clockwork now, about 18 hours after the Peg injection; the worst part usually lasts a day or two. I'm getting used to this part I think. The emotional stuff is less predictable but still manageable, or so it seems to me ;-)    - Lee

[Mister beagle bailey]

Thanks to all, I get it now.  It's 3PM here where I live and there has been only 2 threads opened today.  I'm going to open another so we don't lose it,

  BB if it's not to late.

[Mister beagle bailey]

I just tried and it's already to late.  So today we only have 2 threads, we need to post threads early or we lose them.  Well, tomorrow is another day.

Hope all is well,

  BB

[jmjm530]

Congratulations on being non-detectible!

The Drusano model suggests that genotype 1's (in general) have about a 90% chance of SVR if they treat 36 weeks after they become non-detectible; and an 80% chance of SVR if they treat 32 weeks past being non-detectible. So, for example if you were non-detectible at week #12, then you'd treat for 48 weeks with a 90% chance of SVR.

So, in your case, the question then becomes when did you become non-detectible? If your first and only PCR was at week 24, then you  could assume you were also non-detectible at week 12 but it would only be an assumption.

Regarding the advantages of a 36-week PCR versus just one at 48 weeks. The more PCR's you have, the more certainty you will have that there were no viral breaktrhough between tests. In other words that your non-detectibility was continuous throughout treatment. And conversly, if there is a breakthrough, you'll have a closer approximation of when which can help your doctor deterimine how much longer to treat if that is the route he wants to take.  I think a 36-week PCR is a very good idea. My doctor actually prefers monthly PCR's for his patients during treatment,  although I have them only every 2-3 months.

-- Jim

[strator]

Congratulations!!! That's great news for you! And it helps us other geno 1's keep sluggin away. Thank You!

Ihad the dryness and cracks around the mouth in my 2nd month of tx but it suddenly cleared up there. Hope your sx are mild.
Don