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2147300 tn?1369689688

poison ivy and prednisone on triple

Does anyone have any inf on the effects of prednisone while on triple w/ inc. I am extremely allergic to this ivy and have much difficulty in ridding it from my system.  Creams do not work.  I have bottle of Prednisone in cabinet to knock it out when I get it. I am aware of dangers of its abuse and am educated in how to take it.

Thank you, rog
Best Answer
1815939 tn?1377991799
You are not supposed to take systemic (oral) steroids if you are on Teleprevir (Incivek).

From     www.drugs.com

Drug Interactions

prednisone
ribavirin
Incivek (telaprevir)
Pegasys (peginterferon alfa-2a)

Interactions between your selected drugs
prednisone ↔ telaprevir

Applies to: prednisone, Incivek (telaprevir)

GENERALLY AVOID: Coadministration with telaprevir may increase the plasma concentrations of systemic corticosteroids. The mechanism involves telaprevir inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most steroids. No pharmacokinetic data are currently available, although telaprevir is a potent CYP450 3A4 inhibitor and may interact significantly.

MANAGEMENT: The use of systemic corticosteroids in combination with telaprevir is not recommended. Systemic corticosteroids should not be used to treat telaprevir-induced rash.

No other interactions were found between your selected drugs.
Note: this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.

10 Responses
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766573 tn?1365166466
Oy Bless your heart. You must be miserable. :(

Always remember: Leaves of three, leave them be

http://0.tqn.com/d/walking/1/0/x/g/T_Leaf_Diagram.gif

The one time that happened to me the things on this site helped:
http://www.bloomu.edu/health/poison_ivy

Here is the nuts & bolts if you do not want to read it:

Be sure to clean or swab yourself & your stuff with rubbing alcohol first (because of the oils).

Then clean with soap & water

It is a two-fold approach

The rash:
Application of 1 percent hydrocortisone cream up to four times daily will help decrease itchiness and help to dry the rash (I used use a more potent topical mixed with a little lidocaine)

The itch:
Benadryl or Hydroxizine every four to six hours will help decrease itchiness but may also cause drowsiness. Trust me on this: topical Benadryl cream irritates the rash more than it helps.

Keep in mind, anything that increases body heat will increase the itchiness of the rash.

http://www.hep-druginteractions.org/data/PrintableCharts/DI_bw.pdf
Helpful - 0
2147300 tn?1369689688
My golf partner has agreed to look for my balls when I hit them in the woods. he was int the woods 7 times today if that tells you how my practice round went.
Helpful - 0
163305 tn?1333668571
I was joking about the Ocean of Calamine Lotion, it shows my age, cause I remember that old song, " Poison Ivy."

Really your best bet is to stay covered up, head to toe, and take your clothes off carefully once inside and toss them in the wash. Wash your hands after.
Keeping it off your skin is your best defense.

Good luck~
Helpful - 0
2147300 tn?1369689688
Lotions don't work, It used to be a trip to the dr $100 and shot of steroid. Never been able to shake it. Finally convinced dr to give be script for oral pred and it works like a charm.  I know it is dangerous stuff but it is also magical in what it can do. Thats part of the management drug for the liver immune disease the docs thought I might have in initial testing. No cure just management. On for a couple months then off  for a couple months. Then repeat.  I have friend that abused prednisone for his breathing issues and his wife for her arthritis.  They both ended up in serious trouble and took them 2 years to get straightened out. They sure felt good the first couple months until they destroyed their immune systems.  Yes it is has the stigma and attitude of a gremlin, don't get it wet or it gets nasty.
Helpful - 0
Avatar universal
Yes very important but if anyone can do it you can Roger!  Your right behind were all here to push each other forward we know those Bad Day feels like you want to just quit but keep in mind we have our whole future a head of us!
Helpful - 0
2147300 tn?1369689688
You really gotta pay close attention to lifestyle and risk behavior with this tx.  Not a cake walk and shouldn't be treated as one. Must give full respect to my situation.
Helpful - 0
2147300 tn?1369689688
It appears that my suspicions are quickly being substantiated.  I forgot to ask dr today and have much poison ivy here in woods. Lots of campfires, on our property, love the peacefulness of a fire in evening. This weekend I have 3 day golf tourney and course is loaded with ivy. I have never worried about it before because of the magic of pred but realized I better check interactions.  My game is off a little and I am in woods a little more often this year.  I will confirm with dr in morning and try to keep it down the middle.
   Thank you, rog
Helpful - 0
163305 tn?1333668571
Eeek, I hate that stuff (prednisone( and think it's way over prescribed.
Just my personal view.

My advice is to coverup when outdoors. Tx is hard enough on our skin without adding something itchy like poison oak or ivy.
Better to use an ocean of calamine lotion :)
Helpful - 0
Avatar universal
As well as there being a drug-drug interaction between these drugs as pooh has posted ,it is generally advised to not take sytemic immunospressants while doing HCV therapy

There seems to be ongoing controversy about  immunosuppressive steroid(prednisone) use and how it affects or if it affects  HCV viral replication.

It is a very powerful drug with many uses,
Possibly discussing with your doctor about some other form of therapy for your  problem in light of the fact you have not attained SVR yet and the viral replication uncertainty
(below)

Best.
WIll


In conclusion, despite clinical evidence that the use of steroids aggravates recurrence of HCV, our in vitro study suggests that there is no direct stimulatory effect of steroids on the replication of HCV. As such, the increased viral loads after high-dose steroid treatment are more likely due to a downregulation of the immune response. In such patients, a dampened immune response allows viruses like HCV to replicate free of immune-mediated killing of their host cells. When a change occurs, such as a tapering or an alteration of immunosuppressant drugs, the immune system reinitiates and vigorously attempts to control the virus, resulting in acceleration of liver damage. Therefore, either steroid avoidance or maintaining low levels, coupled with a slow tapering of corticosteroids, may be beneficial to HCV-infected transplantation recipient

http://www.ncbi.nlm.nih.gov/pubmed/17911459?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Helpful - 0
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