i was one to jump into treatment, and VERY glad i had the option to do so... My biggest fear was my children getting this from me, and therfor the #1 reason why i treated with no liver damage. And from what I understand the sooner one treats the better the odds are of clearing.. (The less damage one has the better chance at SVR?) Please correct me if I am wrong
You kinda miss my point. This has to do more with cell to cell transmission and the fact that interferon won't work on this. As far as not giving it to your children I would still be very carefull. I am not a believer of that. Ask your doctor if he would be willing to take a blood transfusion from you. See if you can now donate blood.
after a quick review of the article. i think the point it was making why it is hard for the adaptive immune systme to form effective antibodies. also one of the reasons it has been difficult for researchers to develop an effective vaccine. however the innate or cellular immune response is still fighting the virons considering this is operating effectively.
i am not sure how you concluded SOC will not work based on this article and cell to cell transfer?
It plainly states that antibodies can only attack outside the cell. If the transference is between cells then bosting the imune system with TX will do nothen.
Viruses generally enter a cell, replicate themselves, and burst out of the cell with large numbers of copies to infect another cell in the same manner.
However, some viruses can move directly between cells. "Cell to cell transmission" allows them to bypass some of the body's most potent defence systems as antibodies can only attack outside the cell.
Scientists have so far believed that the Hepatitis C virus does not have the ability to move directly between cells, but this has been disproved by the latest study that involved liver tumour cells infected with the virus.
This is big news and at least for me answers questions I have had for a long time.
Do you have the link to the original full article? I saw your post, and the copied portion of the article that you provided in the post, but no link. I would like to review it, to see if any of the findings tie into the "HCV persistence after SVR" issues, or the possibility of non-blood transmission, from one cell system to another person's cell system (salivary, sexual, gastric, mucous membrane, etc). If there is no antibody response to such an infection or transfer of the virus, then the researcher's findings might support some of my more 'radical' ideas about how the virus may operate. I still strongly suspect a non-blood based, atypical form of transmission between close contacts, intimate partners, and possibly family members...based on a cellular transfer, and non-antibody provoking localized, or compartmentalized infection which is initiated, and maintained by the inewly infected person, but not converted into a full blown HCV blood/liver infection.
If you have more info. on this article, and a link, I would enjoy reviewing it.