Colloidal Silver?

[superinfected]

Does anyone have experience w/ this? Of course my Hepatologist says "NO!", but he said no to milk thistle too, so if it's not expensive pharmaceuticals, he's clueless.  I take milk thistle anyway, w/ good results.

[HCA]

Thank you for posting this.
I was aware that a study of intravenous application of silbinin was underway but I didn't know it had published.
The subjects were all very slow (non) responders and there is slight evidence that adding IV silibinin may have helped push down the viral load.
We don't know the outcome 'cos they are all still on treatment.
Silibinin is a refined form of sylimarin which is the milk thistle product,and the IV administration would have provided a much more intensive dosing regime than the commercially availible product.
I wonder how a better responding group would have done with the same regime.

[Willy50]

HCA, here is a very recent study presented at the 2009 EASL.  It is a small study but this and a number of other studies continue to provide evidence that milk thistle does *something*.  In this case it was used as a supplement with possible antiviral effects.

Many people may also take it for what may be some sort of liver protectant or may have anti-fibrotic properties.  I agree that this is not *proven*, but there exists some evidence that it could be beneficial. ~~willy
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http://www.kenes.com/easl2009/Posters/Abstract517.htm

Presentation Date: Apr 24, 2009
INTRAVENOUS SILIBININ AS “RESCUE TREATMENT” FOR ON TREATMENT NONRESPONDERS TO FULL DOSE OF PEGINTERFERON / RIBAVIRIN COMBINATION THERAPY

K. Rutter1, S. Beinhardt1, H. Kerschner2, T.M. Scherzer1, H. Hofer1, T. Popow-Kraupp2, P. Steindl-Munda1, P. Ferenci1
1Internal Medicine III, Dpt of Gastroenterology and Hepatology, Medical University of Vienna, 2Clinical Virology, Medical University of Vienna, Vienna, Austria

Background: Silibinin (SIL) given intravenously at a dose of 20 mg/kg/day for 14 days had marked antiviral properties in nonresponders to full dose of peginterferon/ribavirin (SOC) combination therapy with chronic hepatitis C (Ferenci et al, Gastroenterology 2008). This confirms the in vitro findings that SIL inhibited viral replication. In this study we extended this treatment approach to on treatment nonresponders, defined as having detectable HCV-RNA after at least 24 weeks of SOC.


Methods: Nine patients HCV-RNA on treatment with 180 µg peginterferon-alfa2a (Pegasys®) and 1000-1200 mg ribavirin (Copegus®)/d who were still HCV-RNA positive after 24 weeks (mean age: 53 ± 6.6 years; male/female: 5/4; genotype 1:7, 3a:1, 4:1; liver fibrosis F4:6, F3:1, n.a.:2) were investigated. Seven patients were treatment naïve, 2 had a previous therapy (one nonresponder, one patient had relapsed twice after 24 weeks therapy). After completing at least 24 weeks of SOC therapy patients received additionally 20 mg/kg/d Silibinin (Legalon-SIL®, Rottapharm-Madaus, Monza, Italy) intravenously for 15 days. Thereafter peginterferon/ribavirin was continued. At the time of writing, all 9 patients are still on therapy. HCV-RNA was quantified by TaqMan® (Roche Diagnostics, USA) at monthly intervals on standard treatment and weekly after starting SIL treatment.


Results: On peginterferon/ribavirin HCV-RNA was quantifiable with a median log drop of 2.3 (range 0.4-5.7) at week 24. Two patients had a detectable but unquantifiable HCV-RNA (< 15 IU/mL). After 15 days of intravenous SIL therapy HCV-RNA decreased in all patients and 7 out of the 9 patients had undetectable HCV-RNA. After the end of SIL administration patients were followed for at least 12 weeks. In one patient HCV-RNA increased to 100 IU/ml, and a second course of intravenous SIL for 15 days was given. HCV-RNA became negative again and remained negative so far. All patients are still on standard of care treatment. Treatment was well tolerated.


Conclusion: Intravenous silibinin is an effective “rescue treatment” for on treatment nonresponders to full dose of peginterferon/ribavirin combination therapy.

[Magnum]

I have to agree with nygirl7. She is one of the smartest, brightest persons on this site. She has an outlook of reality, not a misconception of the algorithms of untruths and unfound statements of so-called truths.

Were it not for the keen eyes of the HCA, this site would become a commercialized fiasco. Let's concentrate on the realities of our affliction, and by doing so, help those who are already confused, and not add to their misery, agony and dead promises of grandeur in a world already filled with scams, half-truths, socialized brain washing, unrealistic presentations of promises to hang your dreams and hopes on... (Oh my Magnum, such profound statements...)

Magnum

[Magnum]

Milk Thistle is fine according to both of my doctors. Naturally, they can't testify it does what it claims to do because of their ethical responsibility to their Hippocratic Oath. However, I've been on it for at least ten years and I will stay on it.

As for Colloidal silver, save your money and instead buy silver coins. Put them away, and when you're healed, cash them in for a trip to the Bahamas, where you can rest in the sand, sipping a nice coo tall Piña Colada or a Banana Daiquiri...

Magnum

[nygirl7]

Why are there advertisments for mesosilver all over this page? Seriously that is not good..........no WONDER people are asking about colloidal silver it's being advertised right on this forum! WTH is going on??????? BAD BAD mojo!

[newleaf09]

HCA, I looked up milk thistle early and found the same thing.  Not helpful but not harmful either.  Gosh, I had enough stuff to take in a trial, 23 pills daily and 1-3 shots a week.  Never missed, rarely late.  Grateful not to add anything more.  Finished 3 weeks ago and can now barely remember to take my one little vitamin pill.  Can't imagine how I did it all.