Incivek Anal Burning

[OJay63]

I'm on my fifth day of Incivek and I'm already considering ending the treatment. The anal burning sensation during and after a bowel movement is nearly unbearable. I'm afraid to eat anything because I know that will cause me to have a bowel movement. It's like giving birth everytime I have a BM. Is this normal? I'm well hydrated and eating fat before taking meds. Any advice on how to make this stop?

[1oftheclub222]

I wonder if the people who write these things have ever experienced the sx their self.....

[crigger]

    It is bad, I know ! This treatment is rough! I found that eating a lot of cheese for my20 gram fat helped  firm the stools. High fiber will cause it to be more bulky.  You need a good balance I do not know about others but mine  got better after a couple of weeks. Now it has settled down a lot. Hang in there. Peperation H, soaking in the tub and a lot of cussing helps

[flcyclist]

The following is from Clinical Care Options: Strategies for Success: Management of Telaprevir-Associated Rash and Anorectal Symptoms

In the controlled trials of telaprevir, anorectal symptoms consisted primarily of hemorrhoids, anorectal discomfort, anal pruritus, and rectal burning.[1] Some patients experience diarrhea while taking telaprevir, which can exacerbate these symptoms. Overall, 29% of patients treated with telaprevir experienced anorectal symptoms. Most events were mild, and it was rare that they were treatment limiting. The median time to onset was 9 days, and the median duration was 57 days.[3] My colleagues and I have found in our practice that these symptoms are troubling or annoying to patients, but tolerable. Moreover, it is very rare that patients need to discontinue treatment due to these events.

Management of anorectal adverse events should target the symptoms through use of topical lubricants (eg, petroleum jelly, aloe vera), topical hydrocortisone cream, and in some cases, topical anesthetics (eg, lidocaine). The underlying approach is to get patients through treatment and to remind them that these symptoms will resolve when the course of telaprevir is complete.

http://www.clinicaloptions.com/Hepatitis/Journal%20Options/Collections/2011%20JO%20Hepatitis%20Volume%205/Articles/Sherman_NEJM_2011/Commentary.aspx
You need to register to view, but well worth it.

[fretboard]

Welcome to the forum OJay.  All I can say is talk to your doctor and ask if there's a prescription type numbing cream you can use.  Do not stop tx, there's gotta be a way to continue.  I've heard of this anal issue and it's really surprising that Vertex was not able to eliminate it from the drug, but it is what it is.  good luck

Here's a link and a cut and paste from it.  

http://www.hcvadvocate.org/hepatitis/factsheets_pdf/SEM_Anal%20Itching.pdf


Managing Anal Itching and Burning
These recommendations are from medical providers
who are working with Incivek:
• For mild-to-moderate itching, try over-thecounter
(OTC) creams or ointments that contain
hydrocortisone. Use these sparingly and as
directed.
• Apply zinc oxide cream such as Desitin or other
protective ointment to the anal region. Calamine
lotion may also help.
• There are many products that provide relief for
anorectal problems. Preparation H offers a variety;
look for one that suits your needs.
• If these measures don’t work, your medical provider
may prescribe a cream or ointment and/or
an antihistamine.
Prevention of anal itching mainly involves washing

[1oftheclub222]

ya, that's the post I was thinking of!

[hrsepwrguy]

follow the link

http://www.medhelp.org/posts/Hepatitis-C/Anal-Issues-Bowel-Movements/show/1629482

also here is this

pooh55811  
Jan 06, 2012 .To: garelli.I was on Incivek for 12 weeks. I have been off of it for 2 1/2 weeks. I had the rectal problems with Incivek. After feeling like I was crapping hot shards of glass, I finaly figured out that the solution is to keep the stools firm, not like a rock, but pretty firm. The minute they get soft or loose, or heaven forbid, diarrhea, they start to burn and truly feel like shards of glass. It took me too tries to figure this out (two episodes of the shards of glass) but I did figure out what worked. TYhe third time it started I nipped it in the bud and cleared up the problem quickly.

To keep the stools firm I took loperimide tabs at the first sign of soft stools. As long as I got it before it got soft, I was fine. I don't know about the fiber. I read some place (but have no idea where) that commercial fiber binds with the pills so I never took any of the drugstore fiber.

Also, use Huggies (with aloe) baby wipes and use them every s single time you go. Keep the rectal area exceptionally clean.The generic brands burn, so I stuck with Huggies.

I also used Prep H suppositories and Prep. H cream. They worked.

Hope this helps because the rectal issues, if they are bad enough, could be a big problem. .