Thanks for the info. - Cuteus, please don't take this wrong but is the it really necessary to drag in names and infer misguided intentions. Sorry, I should probably just keep my big yap shut.
The sublinqual application is certainly a way to circumvent digestion and it is - like intranasal application of Adiuretin/Vasopressin - an accepted and effective route to supply small amounts of high activity peptides. It is limited to small peptides however, with no strict cutoff. The dose for Thymosin alpha eg is 1.6 mg of a 28 aa peptide. It seems to exceed the capacity of this oral mucosa absorptive pathway, but I will actually check with SciClone re this question - if there are any hard data on this. The fact that these thymus extracts - if prepared correctly - and that is a big open question- contain a mixture of several thymic peptidic hormones is intriquing and stimulations of the T cell system are likely to occur to some degree. But all these peptides can easily be injected sc - but the only availabe ones from pharma are Zadaxin and Thymopentina - in Italy - for Thymopentin, they also had Thymolin for a while and THFgamma2 - an extremely interesting peptide.
But St. George - you cannot - or at least should not - inject an extract from an animal gland - unless it is cleared by ultrafiltration from all larger proteins and peptides. That mode of preparation might indeed be the case for some of these preparations - but who wants to undergo the risk to use these ill defined preparations and the high cost with no evidence of dosing and effectiveness beyond anectotal reports from doubtful sources?
At any rate the combo IFN/Thymosin alpha 1.6mg biweekly has been studied and would be of high interest for those seeking to increase their chance for SVR. This might also increase the sides somewhat.
HR: Facteur thymique serique (yes French and it sings well Jim)
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But wasn't the animal gland studies based on smaller french singers with therefore shorter intenstines, Edith Piaf for example?
A more biologically viable source can be imported from europe which is injected sub q therefore bypassing stomach acids. Natcell thymus is taken sublingually and actually does have some immune stimulating activity. I used it once when having an asthma attack ( immune disorder) and it stopped it in its tracks. Raw thymus shifts body into Th1 mode.
in other words, don't believe Lloyd Wright, oral thymus is not going to get rid of your hcv or do you much good, but it will make Mr Wright a nice increase in his bank account.
Natcell produces extracts from animal glands - like the thymus- and sells it to patients for oral consumption with the idea that some of the proteins/peptides survive the digestive power of the stomach/pancreatic enzymes. This is true only to a very limited extent- very small amounts reach the small intestines undigested.
While the thymus contains several hormones like Thymosin alpha, Thymolin, Facteur thymique serique ( yes French and it sings well Jim) and a few more, serious therapeutic research has only been done on thymosin alpha, Thymosin Humoral Factor Gamma two, Thymopentin and Thymolin. All these have to be applied by injection and for HCV and HBV only thymosin alpha had several trials and is approved in several countries in various indications mostly sponsored by SciClone Pharmaceuticals. Thymosin alpha can add power to Interferon treatment both in B and C and might be used more widely in the future.
The Natcell oral extracts however could at best provide minimal amounts of remnant thymic factors too low to be effective.
Sorry, I don't know anything about "live protein" cells. Maybe someone else here does.
All the best,
-- Jim