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Natural compound blocks hepatitis C infection

Natural compound blocks hepatitis C infection
Finding may lead to a new treatment

"Researchers have identified two cellular proteins that are important factors in hepatitis C virus infection, a finding that may result in the approval of new and less toxic treatments for the disease, which can lead to liver cancer and cirrhosis.

An estimated 270 to 300 million people worldwide are infected with hepatitis C and the conventional treatments – interferon and ribavirin – can have significant side effects. A new drug targeting cellular proteins rather than viral proteins would be a valuable addition to the treatment arsenal, said Samuel French, an assistant professor of pathology and senior author of the study."

French and his team set out to identify the cellular factors involved in hepatitis C replication and, using mass spectrometry, found that heat shock proteins (HSPs) 40 and 70 were important for viral infection. HSP 70 was previously known to be involved, but HSP 40 was linked for the first time to hepatitis C infection, French said. They further showed that the natural compound Quercetin, which inhibits the synthesis of these proteins, significantly inhibits viral infection in tissue culture.

"This is an important finding because we can block these proteins with the idea of reducing the level of the virus in people and, ideally, completely eliminate it," said French, who also is a researcher at UCLA's Jonsson Comprehensive Cancer Center.

The study appeared in the most recent issue of the journal Hepatology.

Since Quercetin has been shown to inhibit hepatitis C infection, French said, a Phase I clinical trial will be launched at UCLA to determine if the compound is safe and effective.

Quercetin is a plant-derived bioflavonoid, and is used by some people as a nutritional supplement. Laboratory studies show it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Currently, there are early-stage clinical trials testing quercetin for safety and efficacy against sarcoidosis, asthma and glucose absorption in obesity and diabetes.

"Because Quercetin targets cellular proteins rather than viral proteins, there is less likelihood of developing viral resistance," French said. "Cellular proteins cannot change like viral proteins can.

Many patients in the United States have a type of hepatitis C virus that does not respond to the standard treatments. In these cases, if the virus can't be blocked, end-stage liver disease and, ultimately, death may occur. Once HSP 40 and 70 were identified, French and his team used Quercetin in an attempt to block the proteins and found that the compound "reduced infectious particle production at non-toxic concentrations," according to the study.

"Quercetin may allow for the dissection of the viral life cycle and has potential therapeutic use to reduce virus production with low associated toxicity," the study states.

The UCLA clinical trial will most likely target those with type 1 hepatitis C, which is the non-responsive type prevalent in this country. Only about 50 percent of those with type 1 hepatitis C respond to treatment, French said.

Volunteers with type 1 hepatitis C who opt not to undergo conventional therapies would be recruited for the study. In other studies in other diseases, Quercetin has resulted in no significant side effects, French said.

"A non-toxic treatment for chronic hepatitis C would be great because our current therapies have significant side effects and only a certain percentage of the patient population responds," French said.

###

The three-year study was funded by the National Institutes of Health, the Cure Digestive Diseases Research Center and the Stein Oppenheimer Endowment Award.

UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2009, the Jonsson Cancer Center was named among the top 12 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 10 consecutive years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu."

See:  http://www.eurekalert.org/pub_releases/2010-01/uoc--ncb010410.php

Mike

48 Responses
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179856 tn?1333547362
The Juice wont work. Please.....there is only one cure and Matt's Juicing stuff is not real. Obviously fruits and vegetables are good for you but they do nothing to fight/cure/erase hepC.

This has been hashed over 1000 times on here. Matt has no proof, provides no information and just says his parents were cured drink juice. That's good advice if you want your hepc to survive and grow nice and strong and absolutely destroy your liver over time.

Quite honestly it is nonesense.
Helpful - 0
Avatar universal
Well, imma drink tha juice and what do I got to lose, nothing!! I like vegtables and fruit anyways!!! Thanks Matt! Ill let everyone know how it goes. I dont know any real info about anything yet other than I got hep-c and but blood work looked good, learned it last wk. and that dr. didnt know if they would even treat me according to that blood work cause it looked good so..dont know more than that. Im waiting to get in the clinic now, dont think it will be too long. But in the meantime, im gonna drink that recipe so what exaxctly would you suggest Matt? That recipe you posted, thats it, and then I read that you need to take in a lil bit of pineapple to help with the absorbsion of it? Is that right? My ADD wont let me read all this technical stuff, LOL!!
Helpful - 0
1581056 tn?1296488659
I have been taking a Vitamin, Mineral supplement called Daily Complete, made by the Awareness Company. It is a liqud that needs to be refridgerated to preserve the live enzymes. I take an ounce per day. I am generally quite healthy. I probably contracted Hep C in the late 70's. I had 5 units of blood after giving birth to my son, and the following year had 5 units of blood after experimenting with aspirin for the first time and bled from an artery in my nostril. I found out in 2001 that I had Hep C. I had suspicious symptoms all of those years was flu like often, broken viens in my cheek, problems drinking alcoholic beverages, and only socially. I began taking Daily Complete in '98. It changed me life. Improved my liver biopsy to 0.something, compared to stage 1 for the first one. Check it out. It has everything except the onions. Best wishes.
Helpful - 0
213141 tn?1270662112
An example of someone who was healed by * * * * * * therapy of bladder cancer is Jay Kordich, also known as the "Juiceman" or "Juicedaddy".

All he used was Carrots and Apples. I learnt about juicing from him.

Jay Kordich reveals how he survived cancer:
http://www.youtube.com/watch?v=nmxeLYTMmcQ
Helpful - 0
213141 tn?1270662112
God bless your friend. Yet there are many that are healed miraculously by them which can also not be denied. The before and after photos speak for themselves.
Helpful - 0
Avatar universal
As a matter of fact I am familiar with the ****** Institute.  A good friend of mine with cancer went to Mexico for treatment.  He died about a year later.
Helpful - 0
213141 tn?1270662112
I'm guessing you've never heard of the G e r s o n Institute? They cure cancer and a variety of other diseases and illnesses with juicing.

As for the ulcers.... my Dad had them as he was dying from Hep-C. Had severe heartburn 24/7 and medications didn't work. He had blood in his stool and was practically crying everyday from the pain in his chest. I learnt about green cabbage juice and how they heal ulcers. After 1 drink the heartburn went away all day then came back a little bit the next day. After the 2nd drink the heartburn never came back. After around 10-days he was healed of ulcers and heartburn.

Why don't all Doctors know that?

My Mother once had Kidney stones 20-years ago. She had an operation to have the stones removed only to find that they came back a year later in full force. She did not want to have an operation every year.... so she learnt about how apples and apple juice completely dissolves Kidney Stones.

Why don't all Doctors know that?

A good friend of my Father's had gallstones last year when he came to visit us. He also complained about having painful gallstone attacks everyday. He was considering surgery. We told him about apples and apple juice and how they dissolve gallstones. He had around 10 apples worth of juice everyday for 1 month. By the end of the month he only had 2 mild gallstone attacks in all that time. 1 year later he hasn't had any gallstone attacks and the gallstones are gone.

Why don't all Doctors know that?

I don't believe there's any person on Earth who knows everything. Like you, I am also very thankful for Doctors for all the lives they save and for all of their practical medical practices... yet I realize there's some things not every Doctor knows about.
Helpful - 0
Avatar universal
"Why? They are still in the stone age when it comes to medicine, that's why."

Matt, can you cure cancer, diabetes, arthritis, HIV just to name a few?  I'm not saying control it or lessen the symptoms, I'm saying cure it?  Those stone age researchers will have a cure one day and I'm thankful they are out there.  



Helpful - 0
213141 tn?1270662112
"Why is it that none of the researchers I know draw the same conclusions you do?"

Why? They are still in the stone age when it comes to medicine, that's why. SOC treatment for Hep-C is no different to me than what doctors do for gallstones. They often remove the entire gall bladder. In my view that is barbaric and terrible... since apples or apple juice will dissolve them and stop gallstone attacks completely. I feel the same way about ulcers too.... they can be healed with Green Cabbage juice... even severe ones that cause blood in the stool... yet some people insist on having an operation.

There are many examples and it reminds me of the good ol' days when people believed the world was flat and the universe revolved around earth... and when people got a headache they drilled a hole in their head(trepanation), or got a lobotomy.
Helpful - 0
Avatar universal
hmm, good point - made me get off my lazy b*tt and go down to the kitchen and check  - currently taking 1 capsule 250mg.

The study in question
http://www.ncbi.nlm.nih.gov/pubmed/19839005
used 50uM concentration - though it looks like they also titrated down to 5uM (didn't read it yet)

so what's the MW of quercetin and what's the metabolized availability?  As a data point one ongoing clinical trial is dosing 1 or 2 grams (though they're only looking at subjects with BMI gt 30, which may up the dosage)
http://clinicaltrials.gov/ct2/show/NCT00065676

argh! don't want to buy more of the stuff - hate taking pills and it's expensive..
Helpful - 0
789911 tn?1368636783
I was just joking when I said show me a sign.  The Jewish people were known for requiring a sign.  That is what they were looking for.  It was what they were told to look for.  You all should lighten up some. Everyone gets so wadded up when you say the J word especially.  I just want the truth d%^% If you have faith in something fine.  If you dont fine. a real cure is all that I want for my sake and everyone elses.  No more hogwash.Show me the before and after prove to me what you are saying..  I looked at the after labs but you havnt shown me the before.  Where are they?   I totally believe in a raw whole food diet and health.  I do take Juice Plus and some other necessary supplements like fish oil, milk thistle and C-co q 10 to add to my diet to make sure I get what I need.  Im just getting weary of one more suplement thing after another added to my collection on my countertop.   Why does this have to be so difficult.  I hope I never have to take SOC.  I think that would kill me before the HCV did.  
Helpful - 0
148588 tn?1465778809
"It also has been claimed to have antidepressant properties, however any claim of quercetin action against neurological diseases should be treated with skepticism due to the fact that quercetin is a neurotoxin in vitro."

"Despite these preliminary indications of possible health benefits, quercetin has neither been confirmed as a specific therapeutic for any condition nor has it been approved by any regulatory agency. A bioavailability study done on rats showed that ingested quercetin is extensively metabolized into non-active phenolic acids, with more than 96% of the ingested amount excreted within 72 hours, indicating actual physiological roles, if they exist, involve quercetin in only minute amounts."

"Quercetin is contraindicated with some antibiotics; it may interact with fluoroquinolones (a type of medicinal antibiotic), as quercetin competitively binds to bacterial DNA gyrase. Whether this inhibits or enhances the effect of fluoroquinolones is not entirely clear.[28]

Quercetin is also a potent inhibitor of CYP3A4[29] and CYP2C9[30], which are enzymes that break down most drugs in the body. As such, quercetin would be expected to increase serum levels, and therefore effects, of drugs metabolized by this enzyme."
'
Helpful - 0
1016618 tn?1420553262
Thanks Mike, great information and it gives us more hope.

Teetom
Helpful - 0
338734 tn?1377160168
Why is it that none of the researchers I know draw the same conclusions you do? I haven't found an MD that supports what you are saying. I know you are naming some, but I know many doctors (I have two in my immediate family) and they say there is no basis for your claims regarding cures for viral or bacterial diseases. They tell me it is bad science at best. Why is that? And don't tell me that these people are in the pocket of Big Pharm, because it simply isn't true. If your cure is so miraculous, why is it not the news du jour and in every health class and medical school?

Helpful - 0
213141 tn?1270662112
"Matt: I put considerably more trust in the opinions of the medical researchers when it comes to working of the immune system and virology than others who do not have the knowledge and undestanding no matter what degree of faith they have."

Same here. ;-) Everything I know about veggies and fruit and how they help people with Hep-C comes from medical researchers. I just applied their knowledge and research in the best way possible and got really good results. Why is that is so difficult to understand I wonder? I don't make things up about veggies and fruit... I follow the research and use it to my advantage. The only "faith" involved there is that the veggies and fruit will work as the scientists and researchers describe. I have "faith" in medical researchers too.

i.e. Best way to get "Quercetin" is from things like Apples. "Vitamin-C in Apples helps the body to create natural Interferons." "Apples purify the blood and help remove toxins from the Liver". "Apples dissolve Kidney stones." "Apples help reduce cholesterol, re-activate benefical gut bacteria and relieve constipation." They contain magnesium, calcium, phosphorus, vitamin C, pectin and beta-carotene which also have a variety of other healing properties that are documented by medical researchers.

I wouldn't know these things without medical researchers. You are totally correct about the liver surgery as well and I am trying my best to understand your point of view.

Wishing you well is not good enough, nor is saying prayers for you. It wasn't good enough for my parents... Ultimately what's important is that you get what you need most on this day, whatever that may be.

Matt
Helpful - 0
338734 tn?1377160168
"Later, in heaven, the Lord said, "How about the two boats and a helicopter that I sent?""

I was just telling the joke to make a point, OK? No offense, or religion intended.  

Matt: I put considerably more trust in the opinions of the medical researchers when it comes to working of the immune system and virology than others who do not have the knowledge and undestanding no matter what degree of faith they have. I think it is foolish not to, but that is just my opinion. I would not have let the Pope,Dalai Lama, or Oral Roberts do my liver transplant.
Helpful - 0
Avatar universal
Dimondlil,

These are the persons you should direct your comment to and not exclusively to Matt chin as stated.

His3707 said,

Like the Jewish people said to Jesus, show me a sign..

Berlynn said,

I believe that everything happens in Divine Order so thank you for this bit of HOPE.

And yes even iam the walrus said,

Later, in heaven, the Lord said, "How about the two boats and a helicopter that I sent?"

So from what I have READ this did not start with Matt Chin and your addressing it as you have seen fit to do should have been stated... "To All" that way you would have not gotten this type of reply.

jep

Helpful - 0
Avatar universal
It has been expressly stated by MedHelp that religion (ie: beliefs or interpretations) are not allowed on the hepatitis c forum.  

Diamond_Lil
Helpful - 0
213141 tn?1270662112
"And yes, I believe there is a place for faith in medicine, just not in evaluating the efficacy of treatments."

I totally agree. What good is "faith" for evaluating the efficacy of medicine??? Don't you think scientists/researchers would do a much better job than a person's faith???.... I prefer to rely on the work of researchers and scientists myself..... without their research I wouldn't have had a chance at healing my parents. Like I said, education is the key, knowledge is power. Religion or faith is certainly NOT the solution to knowing the effectiveness of vegetables and fruit for healing the body. Education is the solution.

Faith is completely and utterly useless for "evaluating the efficacy of medical treatments".... Yet "faith" is actually needed to find new cures... without faith/hope for a better solution combined with hard-work, people will NEVER discover new cures for diseases.

Faith without work is dead and useless. As much as you hope, as much as you pray, nothing changes if that is all you do. A person must act upon their faith if they have any, then it might be useful.

"It's like the guy who stayed on top of his house during the flood and who turned down the rescuers and drowned, while having faith that Providence would save him. Later, in heaven, the Lord said, "How about the two boats and a helicopter that I sent?"

Yes, that's a good example of how faith can be completely useless. Yet it's also a great example of how God can answer your prayers through people you meet. How difficult is it to realize when God has answered your prayer and sent someone to help you? How would you know for sure? That was the problem with the guy on the roof... yet many suffer the same, not knowing when God has sent someone to help them, they refuse what God gives them. When they enter heaven they ask: "Why didn't you help me"?

Matthew Jason Chin
Helpful - 0
338734 tn?1377160168
"It's a wicked and stiff necked generation that seeks for a sign", eh?  

Well, as long as we are dealing with religious faith, that is all well and good; but I thought this was a medical forum. And yes, I believe there is a place for faith in medicine, just not in evaluating the efficacy of treatments. I think faith can work miraculous things, just don't put your faith in the wrong place. Having faith is not an excuse for not thinking critically about the choices we have.

It's like the guy who stayed on top of his house during the flood and who turned down the rescuers and drowned, while having faith that Providence would save him. Later, in heaven, the Lord said, "How about the two boats and a helicopter that I sent?"

(no offense intended to the religious, irreligious or otherwise. Just making a point) :-)
Helpful - 0
213141 tn?1270662112
No problem berlynn. I am obligated to share my story with the people here. What a shame it would be if I kept the information to myself. You would do the same if you were in my shoes.

It was a great relief for my parents and my entire family after my parents were healed. They had arguments for years over who gave it to who and they always had that terrible thought in the back of their mind that they might die from Hepatitis-C. My 2 sisters felt bad about it as well. Me, I felt so bad about it that I decided I'd find a way to heal them no matter what. I decided nothing could stop me. I dedicated my life to finding a way to heal them. I declared loudly to my family and friends I'd find a way, and if anyone scoffed, I smiled and brushed it off my shoulder like a fly. I was completely fed up with whimpering and acting as though I was already defeated when I hadn't even taken up arms to fight yet. I didn't stop until I found the way. I was living a lie believing there was nothing I could do to help them.

There is real hope in knowing that you can take responsibility for your own health with the powerful healing agents in ordinary things like Vegetables and Fruit. Education is the key and knowledge is power.

For me... it was a life-changing revelation to learn of the extraordinary healing properties of ordinary veggies and fruit. I am no "vegan", nor am I a "health nut". I enjoy a burger and a soda like many people... yet learning about the healing properties of veggies and fruit for the first time was mind-blowing, and even years later I still learn new things and am still excited about it... I utilize the knowledge when it is needed or useful. One day the healing properties of veggies and fruit will be taught in schools to little Children.

All the research I gathered for my parents can be found at this group here on Medhelp: http://www.medhelp.org/forums/Living-With-Hepatitis-C/show/681

I strongly believe there is hope for people who have not been cured by "SOC treatment", even after multiple attempts. When people say "there's no hope", I say they are sorely mistaken! There's always hope and there's always a better way. So we should never give up! We should never give up on the people we love, or ourselves. Tell those who love you, show them the research and make them read it. If a Family can be educated together and work on this, nothing can stop them. You do not have to believe Vegetables and Fruit will heal you in order for them to heal you. Just believe the research and the things that are proven in the research. Then realize that no man is capable of knowing all things about something as simple as an Apple or Tomato. Realize that all research articles on these things are lacking... There are healing properties in even a Tomato that nobody on Earth can explain yet. Healing substances that haven't even been named yet.

Matthew Jason Chin
Helpful - 0
Avatar universal
Thank you, Thank you, Thank you!!! I am so glad that I checked out the archives and found this. I have not been on this site for a few years. When I looked at my page it says that I have been a member since 2003...which means it was about 6 years since I treated. After 52 weeks of pegasys, I did not sustain remission. For the last 5 years, I have been dealing with still having Hep C, geno 1, but worse, the residual side effects from treatment. I have stayed away from these sites because I could offer little encouragement. Life the way I knew it ended when treatment began.

I actually decided to check out this site to see if there were others like me out there. Unresponsive, relapsed and if they are still dealing with fatigue, reduced cognitive abilities, problems with concentration and memory, arthritis,ect....

I believe that everything happens in Divine Order so thank you for this bit of HOPE.

Personally, I hope people will wait as long as they can before they use interferon and the endless other drugs you end up taking to battle side effects.. I was only at stage 1 when my doctor advised me to do the treatment. I wish I would have waited and tried other modalities. I wish I would have done the research.

I believe the fact that you did so much to help your parents and this community is amazing. I still have Hep C and when I am stressed my liver becomes more inflamed, my counts go up and it effects my thyroid, adrenals, protien ect..... I am very happy you shared this info and I found it.
Bless you !
Helpful - 0
213141 tn?1270662112
"First of all, Thanks for not attacking me and just stating your case.  Have you posted those results somewhere? If you have you should repost them often."

Here's a link to a scanned image of the last test my Dad had for Hep-C showing he's cleared, which I've posted here a few times before: http://members.shaw.ca/ancientskies/hepatitis-c-antibody.jpg

He had Chronic Hepatitis-C for many years before that test was done and was tested for Hep-C many times over the years showing he had the virus.

It will be better when I have copies of his previous tests and hard copies of my Mom's test results to show as well, but even that doesn't actually prove much, since some would still argue it was "Spontaneous Clearance" caused by something unknown.

"Spontaneous Clearance" of HCV is when the body creates a powerful immune response against the virus and kills it off, so in many ways, when someone says it was "Spontaneous Clearance," they are actually correct, except the method to achieve the result is known in my case.

The only way to get real proof and solid evidence would be to have some scientists/researchers do some better studies on the method I used to prove if it's effective, then it would be easier to accept with hard evidence and proof. There is no other way I know of to get hard evidence for it.
Helpful - 0
789911 tn?1368636783
First of all, Thanks for not attacking me and just stating your case.  Have you posted those results somewhere? If you have you should repost them often.   I would love to see them.  Like the Jewish people said to Jesus, show me a sign..  Its like I said, I want to do what you have done for your parents.  I have the opportunity to do alternative med now because I have the option of watchful waiting until the better western drugs come out.  So, I would follow something like you are talking about and do my own labs and see how things go.  Im willing to do my own trial....... and sort of doing it.  Just probably not doing it very well as it what and how much.  Like I have also said, Im confused, annoyed, amongst other things concerning this disease and the treatment of it.  I pray that by the time my son would be old enough to treat the cure will be as simple as taking an anti viral for 10 days.  I feel that is how it will be.    But, for now, if the doctors wont do the first line of defense and  test or educate people about it to stop it from being transmitted around,   Then there will be this forum where only people like you and me can go to to get some answers.  Without this particular forum I would be totally in the dark.  Before this I didnt even know what milk thistle was.   My doctors sure didnt tell me about it until I asked from the info I received here.    When I did ask they said I could take it.  I know why they dont advertise that info.  It might put them out of the HCV business if we stumble upon the right mix without them;.  
Helpful - 0
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