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I thought i would celebrate the new year with new chapter in my life
unfourtunatly today i met my Dr. and he told me the the dragon is back
i saw something in the screen before he starts to speak but i didn't want to believe
so he started to say nothing is critical and so on, but the news was
the're is 1.07 log iu/mL of the dragon which i was clear of since the week 12 of the treatment
i spent 48 weeks in that treatment to come away so disappointed.
i don't know what i am writing, but i got no where to to go to,
unfourtunatly today i met my Dr. and he told me the the dragon is back
i saw something in the screen before he starts to speak but i didn't want to believe
so he started to say nothing is critical and so on, but the news was
the're is 1.07 log iu/mL of the dragon which i was clear of since the week 12 of the treatment
i spent 48 weeks in that treatment to come away so disappointed.
i don't know what i am writing, but i got no where to to go to,
The plot did seem to thicken, but perhaps all due to the writing of the report being unclear and poorly interpreted. It does seem the last lines of this chapter are still being written, and it's looking more and more like the new chapter on the next page may very well begin with the letters you hoped for: SVR...! Best wishes for a good outcome.
Bill, i contacted a Dr. in KSA already 3 hours ago
he explained exactly as you did, but the confusion was because of the report mentioned the 1.07 log iu/mL
that Dr. assumed that if the sensitivity of the test is <12 then it might reach the 11.7 iu/mL
in his opinion it is all about the layout of the report form in the system, it might be the case of explaining what was the <12 means or something
what you think?
Dave, you're right, we are all glad Bill is around
I've sent an email with the result to Abbott as well.
thanks for all of your replies
he explained exactly as you did, but the confusion was because of the report mentioned the 1.07 log iu/mL
that Dr. assumed that if the sensitivity of the test is <12 then it might reach the 11.7 iu/mL
in his opinion it is all about the layout of the report form in the system, it might be the case of explaining what was the <12 means or something
what you think?
Dave, you're right, we are all glad Bill is around
I've sent an email with the result to Abbott as well.
thanks for all of your replies
Thankfully we have Bill on this forum and he noticed something basic immediately that most of us posters on your thread missed, that you really have no viral load. He is a very bright guy who has helped many of us with his knowledge of hcv and treatment. But as he said non of us are doctors
I am sorry for the anxiety, hopefully this will turn to joy when you get confirmation of svr.
- Dave
I am sorry for the anxiety, hopefully this will turn to joy when you get confirmation of svr.
- Dave
You could contact abbott directly (not the local lab who may also give you an incorrect answer) and ask them about your result.
Another suggestion would be to email the results to a hepatologist in another country and describe your situation. I am not sure if you would have to pay for a consult over the phone or by email or if someone would help you. I wish I could suggest someone to you. Perhaps someone else on the forum will have a referral or another suggestion.
- Dave
Another suggestion would be to email the results to a hepatologist in another country and describe your situation. I am not sure if you would have to pay for a consult over the phone or by email or if someone would help you. I wish I could suggest someone to you. Perhaps someone else on the forum will have a referral or another suggestion.
- Dave
Hi Shehabi,
I reviewed the link you provided; I’m convinced that you did not relapse. However, I’m not a doctor; you need a physician to make that statement.
The test results don’t indicate virus is present; they use the ‘<’ sign, which tells us you have LESS than 12 IU/mL; it does not say you HAVE 12 IU/mL. No test available measures to zero (0).
If relapse had occurred, it would have probably happened in the early days after you stopped taking the medication; for instance, when I relapsed, it occurred within 30 day post treatment.
If you had relapsed, your viral load would be expected to be in the 100.000’s or 1.000.000’s by now.
I understand your confusion; I think you somehow need to consult with a qualified physician to put this issue to rest. I imagine your current doctor could refer you to one of his peers for consultation; if not, can you see a doctor in KSA if you must?
Good luck with this effort; I strongly believe you will eventually resolve this satisfactorily. If it were me, I would not do additional treatment until this has been properly resolved
--Bill
I reviewed the link you provided; I’m convinced that you did not relapse. However, I’m not a doctor; you need a physician to make that statement.
The test results don’t indicate virus is present; they use the ‘<’ sign, which tells us you have LESS than 12 IU/mL; it does not say you HAVE 12 IU/mL. No test available measures to zero (0).
If relapse had occurred, it would have probably happened in the early days after you stopped taking the medication; for instance, when I relapsed, it occurred within 30 day post treatment.
If you had relapsed, your viral load would be expected to be in the 100.000’s or 1.000.000’s by now.
I understand your confusion; I think you somehow need to consult with a qualified physician to put this issue to rest. I imagine your current doctor could refer you to one of his peers for consultation; if not, can you see a doctor in KSA if you must?
Good luck with this effort; I strongly believe you will eventually resolve this satisfactorily. If it were me, I would not do additional treatment until this has been properly resolved
--Bill
This is really confusing, although i understand Bill1954 and Dave have a clear idea of what they talking about and i would love to take tashkas' reply for granted but as you all know, this is a case of going through so much pain again for me and for the family as well.
what if i can't find good dr. for second opinion in my country?
what would you do if you were in my situation?
what if i can't find good dr. for second opinion in my country?
what would you do if you were in my situation?
Hello, Shehabi,
you have just joined the club of us who relapsed. Yet, dont get dissapointed, as others said, new medication is on the horizon, and will come soon. I am also the one who is also relapser. With a stage 3 fibrosis, and I ended therapy in Oct. 2008. which means that I am uncovered for last two years, and also waiting for a new therapy, and looking at it as a new hope.
What is your stage of fibrosis?
you have just joined the club of us who relapsed. Yet, dont get dissapointed, as others said, new medication is on the horizon, and will come soon. I am also the one who is also relapser. With a stage 3 fibrosis, and I ended therapy in Oct. 2008. which means that I am uncovered for last two years, and also waiting for a new therapy, and looking at it as a new hope.
What is your stage of fibrosis?
Shehabi,
I looked at your link. You are SVR and still undetected. Sorry for all the pain you had to experience. Your doctor is wrong in his conclusion.
Happy New Year to you!
I looked at your link. You are SVR and still undetected. Sorry for all the pain you had to experience. Your doctor is wrong in his conclusion.
Happy New Year to you!
I agree with bill. I think you are probably svr or you have some misinformation. People who relapse do not have viral loads of 12 iu/ml at 6 months post treatment.
The lower limit of the test is 12 iu/ml from what I understand and you are under < 12 from what you just posted. I believe you are svr. a second guarded congrats to you!
If your doctor is wrong you won't be the first or last person to get misinformation about these pcr tests.
Hope we are right - Dave
http://www.ilexmedical.com/FileServer/f4389079a7794a844d8f8dd881197182.pdf
Abbott RealTime HCV Performance*
Sensitivity 12 IU/ml for 0.5 ml input, 30 IU/ml for 0.2 ml input
Linear Range 12 IU/ml (1.08 log IU/ml) to 100 million IU/ml (log 8.0 IU/ml)
Precision Inter-assay SD at 5.96 log IU/ml = 0.08, Inter-assay SD at 1.96 log IU/ml = 0.11
Specificity ≥ 99.5%†
Genotype Detection Equal quantification of genotype 1, 2, 3, 4, 5 and 6
Standardization Second WHO international standard for HCV RNA
Internal Control Added to lysis buffer during extraction and detected at all levels
* Performance
The lower limit of the test is 12 iu/ml from what I understand and you are under < 12 from what you just posted. I believe you are svr. a second guarded congrats to you!
If your doctor is wrong you won't be the first or last person to get misinformation about these pcr tests.
Hope we are right - Dave
http://www.ilexmedical.com/FileServer/f4389079a7794a844d8f8dd881197182.pdf
Abbott RealTime HCV Performance*
Sensitivity 12 IU/ml for 0.5 ml input, 30 IU/ml for 0.2 ml input
Linear Range 12 IU/ml (1.08 log IU/ml) to 100 million IU/ml (log 8.0 IU/ml)
Precision Inter-assay SD at 5.96 log IU/ml = 0.08, Inter-assay SD at 1.96 log IU/ml = 0.11
Specificity ≥ 99.5%†
Genotype Detection Equal quantification of genotype 1, 2, 3, 4, 5 and 6
Standardization Second WHO international standard for HCV RNA
Internal Control Added to lysis buffer during extraction and detected at all levels
* Performance
Bill1954
take a look at this link
http://img251.imageshack.us/img251/6518/labresult.jpg
take a look at this link
http://img251.imageshack.us/img251/6518/labresult.jpg
With all due respect to your doctor, I feel he might be misinformed, Shehadi; or that perhaps there is some miscommunication.
If the test results indicate ‘<12, 1.07 log’, then it is likely below the limit of quantification. The arrow ‘<’ = less than; so it’s fair to assume you’re viral load is less than 12 IU/mL.
If your doctor’s statement was true, none of us would become virus negative; successful treatment results appear as yours does now.
Is it possible to discuss this with another specialist, as a second opinion? I would urge you to do so; I think you’ll be pleased with the consult.
Guarded congratulations,
Bill
If the test results indicate ‘<12, 1.07 log’, then it is likely below the limit of quantification. The arrow ‘<’ = less than; so it’s fair to assume you’re viral load is less than 12 IU/mL.
If your doctor’s statement was true, none of us would become virus negative; successful treatment results appear as yours does now.
Is it possible to discuss this with another specialist, as a second opinion? I would urge you to do so; I think you’ll be pleased with the consult.
Guarded congratulations,
Bill
spectda, yes i am 1b
Bill1954 & spectda, I have a hard copy it says <12 1.07 log iu/mL
i've spoken to Dr. with this regards as this is really wired number and he said that while it is detectable (no matter what quantity) then it is there, he advised to re-do the test after 3 months.
Bill1954 & spectda, I have a hard copy it says <12 1.07 log iu/mL
i've spoken to Dr. with this regards as this is really wired number and he said that while it is detectable (no matter what quantity) then it is there, he advised to re-do the test after 3 months.
Same thing happened to me (relapse).
Chronic Hepatitis C may induce the development of Insulin Resitance. IR impairs TX response, and aggravates liver fibrosis progression. Several known factors that affect IR are age, BMI, gender, steatosis, and fibrosis. IR is more likely to develop in G1's than G2's. Patients who have unsatisfactory responses to TX, may benefit by decreasing IR (read my journal) before antiviral therapy in order to improve therapeutic outcomes.
Wishing you good luck in preparation for your next round. (unless you already beat the dragon)
Chronic Hepatitis C may induce the development of Insulin Resitance. IR impairs TX response, and aggravates liver fibrosis progression. Several known factors that affect IR are age, BMI, gender, steatosis, and fibrosis. IR is more likely to develop in G1's than G2's. Patients who have unsatisfactory responses to TX, may benefit by decreasing IR (read my journal) before antiviral therapy in order to improve therapeutic outcomes.
Wishing you good luck in preparation for your next round. (unless you already beat the dragon)
Bill is correct. Perhaps your result said < 1.7 (rather then 1.07) I wonder if the test wasn't good till 43 iu/ml and you are undetectable and svr. You should definitely take bill's suggestion and get the hard copy
Here is an example of one such pcr's range. not sure which one was used for you.
The COBAS® AmpliPrep/COBAS® TaqMan® HCV assay
utilizes real-time reverse transcriptase PCR chemistry to
measure HCV viral load over a broad dynamic range. The
assay has an analytic range of 1.6–7.8 log HCV RNA IU/mL
(43 to 69,000,000 IU/mL).
Here is an example of one such pcr's range. not sure which one was used for you.
The COBAS® AmpliPrep/COBAS® TaqMan® HCV assay
utilizes real-time reverse transcriptase PCR chemistry to
measure HCV viral load over a broad dynamic range. The
assay has an analytic range of 1.6–7.8 log HCV RNA IU/mL
(43 to 69,000,000 IU/mL).
Hi Shehabi,
Can you please confirm the log value of your result is log 1.07 IU/mL?
If so, it’s likely you are undetectable for virus; log 1.07 IU/mL = 11 IU/mL; this is usually considered negligible viral load.
If true, you should rejoice with SVR.
Maybe you can request a paper copy of the result and post it as it appears here in the forum?
--Bill
Can you please confirm the log value of your result is log 1.07 IU/mL?
If so, it’s likely you are undetectable for virus; log 1.07 IU/mL = 11 IU/mL; this is usually considered negligible viral load.
If true, you should rejoice with SVR.
Maybe you can request a paper copy of the result and post it as it appears here in the forum?
--Bill
I am sorry to hear of your relapse. I can only imagine how difficult and disheartening this is for you.
Telaprevir a powerful direct anti viral protease inhibitor should be approved in about 6-8 months and will be added to peg-interferon and ribavirin. This should increase the odds of SVR in genotype 1a and 1b from about 45% to 75%. I assumed you had genotype 1a or 1b because you treated for 48 weeks, is that correct?
Also Boceprevir should be approved sometime next year which is similar to Telaprevir. I hope they will be available to you in Bahrain.
There is much hope for your eradicating this virus for good.
Take Care,
Dave
Telaprevir a powerful direct anti viral protease inhibitor should be approved in about 6-8 months and will be added to peg-interferon and ribavirin. This should increase the odds of SVR in genotype 1a and 1b from about 45% to 75%. I assumed you had genotype 1a or 1b because you treated for 48 weeks, is that correct?
Also Boceprevir should be approved sometime next year which is similar to Telaprevir. I hope they will be available to you in Bahrain.
There is much hope for your eradicating this virus for good.
Take Care,
Dave
Susan_1a_CC
Thanks for your reply, it is over 6 months since I finished my 48 weeks of treatment.
Copyman, can u give details about the new drugs? Please
Thanks
Thanks for your reply, it is over 6 months since I finished my 48 weeks of treatment.
Copyman, can u give details about the new drugs? Please
Thanks
sorry for you to hear this news. the dragon won this time but in about 6 months when the new drugs come out you will win. the dragon is no match for the new drugs.
hang in there
hang in there
That is disappointing news. How long since the end of your tx? I am sure that many people will offer their support and guidance and reassurance about the new drugs that should soon be available. I know that this isn't how you expected to enter the new year but you will find your way through this chapter as well.
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