Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[Whrose]

quote: "PPC,NAC,ALA,TNG,SAme,silymarin,catecchin,resveratrol,curcumin, are probably a very good component of a minimum lover health regimen."

would you please elaborate on the recommended therapeutic doses of each of the above.

am starting to get it (although i wish i could pull up your discussions from a year ago regarding your lengthy explanation of the eubiosis/probiotic/prebiotic concept. the prevention of pro inflammatory LPS input to the liver from the intestines. will contiue to try

now i know i am the cow in the field for interupting this great discussion! all are welcomed to ring the bell on the cow. sigh

may i suggest......please consider writing a short reference book of nutrition and liver health and market it soon as possible! i would love to have it as a reference since you won't adopt me.

[GoofyDad]

I really don't know. Just sharing some info I received on PC vs PPC. All things being equal - I'd say go with Hepatapro, as it's been vetted by our resident expert....

[gauf]

Yes, bur PhosCol is cheaper, so is it comparable?

[TravelMom]

Hepatapro IS PPC.... This is a good product..

[gauf]

Does this mean that PhosCol is the same as hepapro? Does it meet HRs' criteria? Thanks.

[mikesimon]

Thank you for your clarification. You bring us a wealth of information and you always conduct yourself as a gentleman. I feel I am in rarefied company when I read your posts.  Mike