Research supported antifibrotics - do they exist?

[Hepatitis Researcher]

The problems of treatment failure for SOC/IFN nonresponders and the possibility of reducing future supercombo-SVRchances by introducing archived resistance mutations when using "Pseudomonotherapy" - (that is here defined as using  a single  antiviral agent that is not protected against resistance development by its combo with an IFN/riba component (IFN by definition in this scenario is not sufficiently effective in reducing viral replication so that all the burden to tame the adaptive quasispecies evolution falls on the antiviral)) together with the 61% and 65% SVR rates for the latest triple modality in Geno 1s, have raised concern and the awareness for the need for alternate/additional treatment modalities in many HCV patients and their health care providers. Waiting for future antiviral developments is one route frequently recommended, but for the patients  in current need, our repertoire of additional meaningful approaches needs to be carefully reevaluated. Using antifibrotics to halt fibrosis progression is one concept not proven in large trials but it might well be effective in many, because the mechanisms for fibrosis generation are not intrinsically linked to HCV persistence, but rather to secondary response mechanisms evoked in the chronically inflamed liver, with the stellate cell activation holding center stage in this scenario. The following is one of several possible add on modalities.

[Hepatitis Researcher]

No, lecithin ("choline in food?")was used as a control in the Charles Lieber trials and failed to give the same effect, not surprisingly, considering the importance of the fatty acid tail to be polyunsaturated for membane fluidity and functionality.

[GoofyDad]

I certainintly can't comment on the quality and purity - nor would I put HR on the spot by asking him to - but here's the brand I buy - which is a bit less spendy:  

http://www.vitacost.com/NSI-Phosphatidyl-Choline/cas-1


I also buy their resveratrol:
http://www.vitacost.com/NSI-Resveratrol

and a liver furmula:
http://www.vitacost.com/NSI-Healthy-Liver-Version-2

[drofi]

the study is from 1998 and unfortunately there is a bigger study, which was done in the meantime (2003):
PPC treatment for 2 years did not affect progression of liver fibrosis.
http://tinyurl.com/2ctmuq
http://tinyurl.com/ytct8a
A promissing substance might be mp-1021 from Metriopharm: http://tinyurl.com/274j8h

Regards, drofi

[scratchinghead]

Hey thanks! I love vitacost.

[scratchinghead]

Your Metriopharm link was in german. Act lieber!!

[jmjm530]

I noticed you've been loading up at the health food store since finishing treatment. Would you mind listing your current regimen (you can leave out all bowel movement -related products),  why you're taking, any clinical changes from the supplements, any sfx positive or negative.

Thanks

-- Jim